Antiplasmodial and leishmanicidal activities of 2-cyano-3-(4-phenylpiperazine-1-carboxamido) quinoxaline 1,4-dioxide derivatives.

Malaria and leishmaniasis are two of the World’s most important tropical parasitic diseases. Thirteen new 2-cyano-3-(4-phenylpiperazine-1-carboxamido) quinoxaline 1,4-dioxide derivatives (CPCQs) were synthesized and evaluated for their in vitro antimalarial and antileishmanial activity against eryth...

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Autores: Barea, C. (Carlos)|||/items/4f4c9d7c-4235-491b-9444-7a90d51c223d, Pabon, A. (Adriana)|||/items/49b4dd33-b935-4fa8-bfc7-8bb9e2a92b49, Galiano, S. (Silvia)|||/items/10b9d373-6e6e-46e4-bfae-e7b241dad5fd, Pérez-Silanes, S. (Silvia)|||/items/e5734c65-2dd8-4fdd-a74a-fc7526136c45, Gonzalez, G. (Germán)|||/items/c2dc077d-6791-48a8-ae3e-3b6e5bded95b, Deyssard, C. (Chloe)|||/items/6b1e4f49-78f2-40da-bbc8-91e0403eefe1, Monge, A. (Antonio)|||/items/804a350e-c7ff-4318-9742-cdc3432eb2a8, Deharo, E. (Eric)|||/items/48bf3a09-fa0f-4898-8f39-dce9f0fcdef9, Aldana, I. (Ignacio)|||/items/2a317afc-d6ab-4970-8bac-41d9715f5618
Tipo de recurso: artículo
Fecha de publicación:2012
País:España
Institución:Universidad de Navarra
Repositorio:Dadun. Depósito Académico Digital de la Universidad de Navarra
Idioma:inglés
OAI Identifier:oai:dadun.unav.edu:10171/23601
Acceso en línea:https://hdl.handle.net/10171/23601
Access Level:acceso abierto
Palabra clave:Quinxaline
Piperazine
Plasmodium
Leishmania
VERO
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spelling Antiplasmodial and leishmanicidal activities of 2-cyano-3-(4-phenylpiperazine-1-carboxamido) quinoxaline 1,4-dioxide derivatives.Barea, C. (Carlos)|||/items/4f4c9d7c-4235-491b-9444-7a90d51c223dPabon, A. (Adriana)|||/items/49b4dd33-b935-4fa8-bfc7-8bb9e2a92b49Galiano, S. (Silvia)|||/items/10b9d373-6e6e-46e4-bfae-e7b241dad5fdPérez-Silanes, S. (Silvia)|||/items/e5734c65-2dd8-4fdd-a74a-fc7526136c45Gonzalez, G. (Germán)|||/items/c2dc077d-6791-48a8-ae3e-3b6e5bded95bDeyssard, C. (Chloe)|||/items/6b1e4f49-78f2-40da-bbc8-91e0403eefe1Monge, A. (Antonio)|||/items/804a350e-c7ff-4318-9742-cdc3432eb2a8Deharo, E. (Eric)|||/items/48bf3a09-fa0f-4898-8f39-dce9f0fcdef9Aldana, I. (Ignacio)|||/items/2a317afc-d6ab-4970-8bac-41d9715f5618QuinxalinePiperazinePlasmodiumLeishmaniaVEROMalaria and leishmaniasis are two of the World’s most important tropical parasitic diseases. Thirteen new 2-cyano-3-(4-phenylpiperazine-1-carboxamido) quinoxaline 1,4-dioxide derivatives (CPCQs) were synthesized and evaluated for their in vitro antimalarial and antileishmanial activity against erythrocytic forms of Plasmodium falciparum and axenic forms of Leishmania infantum. Their toxicity against VERO cells (normal monkey kidney cells) was also assessed. None of the tested compounds was efficient against Plasmodium, but two of them showed good activity against Leishmania. Toxicity on VERO was correlated with leishmanicidal properties.MDPIDadun. Depósito Académico Digital Universidad de Navarra20122012-10-3120122012-01-0120122012-01-01journal articlehttp://purl.org/coar/resource_type/c_6501info:eu-repo/semantics/articleapplication/pdfhttps://hdl.handle.net/10171/23601reponame:Dadun. Depósito Académico Digital de la Universidad de Navarrainstname:Universidad de NavarraInglésengopen accesshttp://purl.org/coar/access_right/c_abf2info:eu-repo/semantics/openAccessoai:dadun.unav.edu:10171/236012026-06-21T12:47:57Z
dc.title.none.fl_str_mv Antiplasmodial and leishmanicidal activities of 2-cyano-3-(4-phenylpiperazine-1-carboxamido) quinoxaline 1,4-dioxide derivatives.
title Antiplasmodial and leishmanicidal activities of 2-cyano-3-(4-phenylpiperazine-1-carboxamido) quinoxaline 1,4-dioxide derivatives.
spellingShingle Antiplasmodial and leishmanicidal activities of 2-cyano-3-(4-phenylpiperazine-1-carboxamido) quinoxaline 1,4-dioxide derivatives.
Barea, C. (Carlos)|||/items/4f4c9d7c-4235-491b-9444-7a90d51c223d
Quinxaline
Piperazine
Plasmodium
Leishmania
VERO
title_short Antiplasmodial and leishmanicidal activities of 2-cyano-3-(4-phenylpiperazine-1-carboxamido) quinoxaline 1,4-dioxide derivatives.
title_full Antiplasmodial and leishmanicidal activities of 2-cyano-3-(4-phenylpiperazine-1-carboxamido) quinoxaline 1,4-dioxide derivatives.
title_fullStr Antiplasmodial and leishmanicidal activities of 2-cyano-3-(4-phenylpiperazine-1-carboxamido) quinoxaline 1,4-dioxide derivatives.
title_full_unstemmed Antiplasmodial and leishmanicidal activities of 2-cyano-3-(4-phenylpiperazine-1-carboxamido) quinoxaline 1,4-dioxide derivatives.
title_sort Antiplasmodial and leishmanicidal activities of 2-cyano-3-(4-phenylpiperazine-1-carboxamido) quinoxaline 1,4-dioxide derivatives.
dc.creator.none.fl_str_mv Barea, C. (Carlos)|||/items/4f4c9d7c-4235-491b-9444-7a90d51c223d
Pabon, A. (Adriana)|||/items/49b4dd33-b935-4fa8-bfc7-8bb9e2a92b49
Galiano, S. (Silvia)|||/items/10b9d373-6e6e-46e4-bfae-e7b241dad5fd
Pérez-Silanes, S. (Silvia)|||/items/e5734c65-2dd8-4fdd-a74a-fc7526136c45
Gonzalez, G. (Germán)|||/items/c2dc077d-6791-48a8-ae3e-3b6e5bded95b
Deyssard, C. (Chloe)|||/items/6b1e4f49-78f2-40da-bbc8-91e0403eefe1
Monge, A. (Antonio)|||/items/804a350e-c7ff-4318-9742-cdc3432eb2a8
Deharo, E. (Eric)|||/items/48bf3a09-fa0f-4898-8f39-dce9f0fcdef9
Aldana, I. (Ignacio)|||/items/2a317afc-d6ab-4970-8bac-41d9715f5618
author Barea, C. (Carlos)|||/items/4f4c9d7c-4235-491b-9444-7a90d51c223d
author_facet Barea, C. (Carlos)|||/items/4f4c9d7c-4235-491b-9444-7a90d51c223d
Pabon, A. (Adriana)|||/items/49b4dd33-b935-4fa8-bfc7-8bb9e2a92b49
Galiano, S. (Silvia)|||/items/10b9d373-6e6e-46e4-bfae-e7b241dad5fd
Pérez-Silanes, S. (Silvia)|||/items/e5734c65-2dd8-4fdd-a74a-fc7526136c45
Gonzalez, G. (Germán)|||/items/c2dc077d-6791-48a8-ae3e-3b6e5bded95b
Deyssard, C. (Chloe)|||/items/6b1e4f49-78f2-40da-bbc8-91e0403eefe1
Monge, A. (Antonio)|||/items/804a350e-c7ff-4318-9742-cdc3432eb2a8
Deharo, E. (Eric)|||/items/48bf3a09-fa0f-4898-8f39-dce9f0fcdef9
Aldana, I. (Ignacio)|||/items/2a317afc-d6ab-4970-8bac-41d9715f5618
author_role author
author2 Pabon, A. (Adriana)|||/items/49b4dd33-b935-4fa8-bfc7-8bb9e2a92b49
Galiano, S. (Silvia)|||/items/10b9d373-6e6e-46e4-bfae-e7b241dad5fd
Pérez-Silanes, S. (Silvia)|||/items/e5734c65-2dd8-4fdd-a74a-fc7526136c45
Gonzalez, G. (Germán)|||/items/c2dc077d-6791-48a8-ae3e-3b6e5bded95b
Deyssard, C. (Chloe)|||/items/6b1e4f49-78f2-40da-bbc8-91e0403eefe1
Monge, A. (Antonio)|||/items/804a350e-c7ff-4318-9742-cdc3432eb2a8
Deharo, E. (Eric)|||/items/48bf3a09-fa0f-4898-8f39-dce9f0fcdef9
Aldana, I. (Ignacio)|||/items/2a317afc-d6ab-4970-8bac-41d9715f5618
author2_role author
author
author
author
author
author
author
author
dc.contributor.none.fl_str_mv Dadun. Depósito Académico Digital Universidad de Navarra
dc.subject.none.fl_str_mv Quinxaline
Piperazine
Plasmodium
Leishmania
VERO
topic Quinxaline
Piperazine
Plasmodium
Leishmania
VERO
description Malaria and leishmaniasis are two of the World’s most important tropical parasitic diseases. Thirteen new 2-cyano-3-(4-phenylpiperazine-1-carboxamido) quinoxaline 1,4-dioxide derivatives (CPCQs) were synthesized and evaluated for their in vitro antimalarial and antileishmanial activity against erythrocytic forms of Plasmodium falciparum and axenic forms of Leishmania infantum. Their toxicity against VERO cells (normal monkey kidney cells) was also assessed. None of the tested compounds was efficient against Plasmodium, but two of them showed good activity against Leishmania. Toxicity on VERO was correlated with leishmanicidal properties.
publishDate 2012
dc.date.none.fl_str_mv 2012
2012-10-31
2012
2012-01-01
2012
2012-01-01
dc.type.none.fl_str_mv journal article
http://purl.org/coar/resource_type/c_6501
dc.type.openaire.fl_str_mv info:eu-repo/semantics/article
format article
dc.identifier.none.fl_str_mv https://hdl.handle.net/10171/23601
url https://hdl.handle.net/10171/23601
dc.language.none.fl_str_mv Inglés
eng
language_invalid_str_mv Inglés
language eng
dc.rights.none.fl_str_mv open access
http://purl.org/coar/access_right/c_abf2
dc.rights.openaire.fl_str_mv info:eu-repo/semantics/openAccess
rights_invalid_str_mv open access
http://purl.org/coar/access_right/c_abf2
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv MDPI
publisher.none.fl_str_mv MDPI
dc.source.none.fl_str_mv reponame:Dadun. Depósito Académico Digital de la Universidad de Navarra
instname:Universidad de Navarra
instname_str Universidad de Navarra
reponame_str Dadun. Depósito Académico Digital de la Universidad de Navarra
collection Dadun. Depósito Académico Digital de la Universidad de Navarra
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repository.mail.fl_str_mv
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