Higher reproducibility of phase derived metrics from electrocardiographic imaging during atrial fibrillation in patients remaining in sinus rhythm after pulmonary vein isolation

[EN] Background: Electrocardiographic imaging (ECGI) allows evaluating the complexity of the reentrant activity of atrial fibrillation (AF) patients. In this study, we evaluated the ability of ECGI metrics to predict the success of pulmonary vein isolation (PVI) to treat AF. Methods: ECGI of 24 AF p...

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Autores: Molero-Alabau, Rubén, Soler Torro, Jose Manuel, Martínez Alzamora, Mª Nieves|||0000-0002-8305-7963, Andreu M. Climent|||0000-0002-7260-8811, Guillem Sánchez, María Salud|||0000-0001-5660-3693
Tipo de recurso: artículo
Fecha de publicación:2021
País:España
Institución:Universitat Politècnica de València (UPV)
Repositorio:RiuNet. Repositorio Institucional de la Universitat Politécnica de Valéncia
Idioma:inglés
OAI Identifier:oai:riunet.upv.es:10251/183953
Acceso en línea:https://riunet.upv.es/handle/10251/183953
Access Level:acceso abierto
Palabra clave:Atrial fibrillation
Electrocardiographic imaging
Reproducibility
Reentrant activity
Pulmonary vein isolation
TECNOLOGIA ELECTRONICA
ESTADISTICA E INVESTIGACION OPERATIVA
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spelling Higher reproducibility of phase derived metrics from electrocardiographic imaging during atrial fibrillation in patients remaining in sinus rhythm after pulmonary vein isolationMolero-Alabau, RubénSoler Torro, Jose ManuelMartínez Alzamora, Mª Nieves|||0000-0002-8305-7963Andreu M. Climent|||0000-0002-7260-8811Guillem Sánchez, María Salud|||0000-0001-5660-3693Atrial fibrillationElectrocardiographic imagingReproducibilityReentrant activityPulmonary vein isolationTECNOLOGIA ELECTRONICAESTADISTICA E INVESTIGACION OPERATIVA[EN] Background: Electrocardiographic imaging (ECGI) allows evaluating the complexity of the reentrant activity of atrial fibrillation (AF) patients. In this study, we evaluated the ability of ECGI metrics to predict the success of pulmonary vein isolation (PVI) to treat AF. Methods: ECGI of 24 AF patients (6 males, 13 paroxysmal, 61.8 +/- 14 years) was recorded prior to PVI. Patients were distributed into two groups based on their PVI outcome 6 months after ablation (sinus vs. arrhythmia recurrence). Metrics derived from phase analysis of ECGI signals were computed for two different temporal segments before ablation. Correlation analysis and variability over time were studied between the two recorded segments and were compared between patient groups. Results: Temporal variability of both rotor duration and spatial entropy of the rotor histogram presented statistical differences between groups with different PVI outcome (p < 0.05). The reproducibility of reentrant metrics was higher (R-2 > 0.8) in patients with good outcome rather than arrhythmia recurrence patients (R-2 < 0.62). Prediction of PVI success based on ECGI temporal variability metrics allows for an increased specificity over the classification into paroxysmal or persistent (0.85 vs. 0.64). Conclusions: Patients with favorable PVI outcome present ECGI metrics more reproducible over time than patients with AF recurrence. These results suggest that ECGI derived metrics may allow selecting which patients would benefit from ablation therapies.This work was supported by: Instituto de Salud Carlos III, and Ministerio de Ciencia, Innovacion y Universidades (supported by FEDER Fondo Europeo de Desarrollo Regional PI17/01106 and RYC2018- 024346B-750), EIT Health (Activity code 19600, EIT Health is supported by EIT, a body of the European Union) and Generalitat Valenciana Conselleria d'Educacio, Investigacio, Cultura i Esport (ACIF/2020/265).ElsevierDepartamento de Ingeniería ElectrónicaEscuela Técnica Superior de Ingeniería de TelecomunicaciónInstituto Universitario de Tecnologías de la Información y ComunicacionesDepartamento de Estadística e Investigación Operativa Aplicadas y CalidadEscuela Técnica Superior de Ingeniería Aeroespacial y Diseño IndustrialEscuela Técnica Superior de Ingeniería IndustrialGeneralitat ValencianaInstituto de Salud Carlos IIIEuropean Regional Development FundMinisterio de Ciencia, Innovación y UniversidadesRepositorio Institucional de la Universitat Politècnica de València Riunet20212021-12-01journal articlehttp://purl.org/coar/resource_type/c_6501VoRhttp://purl.org/coar/version/c_970fb48d4fbd8a85info:eu-repo/semantics/articleapplication/pdfapplication/pdfhttps://riunet.upv.es/handle/10251/183953reponame:RiuNet. Repositorio Institucional de la Universitat Politécnica de Valénciainstname:Universitat Politècnica de València (UPV)InglésengMinisterio de Ciencia, Innovación y Universidades https://doi.org/10.13039/100014440 RYC2018-024346-IGeneralitat Valenciana https://doi.org/10.13039/501100003359 ACIF%2F2020%2F265European Regional Development Fund https://doi.org/10.13039/501100008530 EITHealth 19600 AFFINEInstituto de Salud Carlos III https://doi.org/10.13039/501100004587 PI17%2F01106open accesshttp://purl.org/coar/access_right/c_abf2Reconocimiento - No comercial - Sin obra derivada (by-nc-nd) http://creativecommons.org/licenses/by-nc-nd/4.0/info:eu-repo/semantics/openAccessoai:riunet.upv.es:10251/1839532026-06-13T07:49:27Z
dc.title.none.fl_str_mv Higher reproducibility of phase derived metrics from electrocardiographic imaging during atrial fibrillation in patients remaining in sinus rhythm after pulmonary vein isolation
title Higher reproducibility of phase derived metrics from electrocardiographic imaging during atrial fibrillation in patients remaining in sinus rhythm after pulmonary vein isolation
spellingShingle Higher reproducibility of phase derived metrics from electrocardiographic imaging during atrial fibrillation in patients remaining in sinus rhythm after pulmonary vein isolation
Molero-Alabau, Rubén
Atrial fibrillation
Electrocardiographic imaging
Reproducibility
Reentrant activity
Pulmonary vein isolation
TECNOLOGIA ELECTRONICA
ESTADISTICA E INVESTIGACION OPERATIVA
title_short Higher reproducibility of phase derived metrics from electrocardiographic imaging during atrial fibrillation in patients remaining in sinus rhythm after pulmonary vein isolation
title_full Higher reproducibility of phase derived metrics from electrocardiographic imaging during atrial fibrillation in patients remaining in sinus rhythm after pulmonary vein isolation
title_fullStr Higher reproducibility of phase derived metrics from electrocardiographic imaging during atrial fibrillation in patients remaining in sinus rhythm after pulmonary vein isolation
title_full_unstemmed Higher reproducibility of phase derived metrics from electrocardiographic imaging during atrial fibrillation in patients remaining in sinus rhythm after pulmonary vein isolation
title_sort Higher reproducibility of phase derived metrics from electrocardiographic imaging during atrial fibrillation in patients remaining in sinus rhythm after pulmonary vein isolation
dc.creator.none.fl_str_mv Molero-Alabau, Rubén
Soler Torro, Jose Manuel
Martínez Alzamora, Mª Nieves|||0000-0002-8305-7963
Andreu M. Climent|||0000-0002-7260-8811
Guillem Sánchez, María Salud|||0000-0001-5660-3693
author Molero-Alabau, Rubén
author_facet Molero-Alabau, Rubén
Soler Torro, Jose Manuel
Martínez Alzamora, Mª Nieves|||0000-0002-8305-7963
Andreu M. Climent|||0000-0002-7260-8811
Guillem Sánchez, María Salud|||0000-0001-5660-3693
author_role author
author2 Soler Torro, Jose Manuel
Martínez Alzamora, Mª Nieves|||0000-0002-8305-7963
Andreu M. Climent|||0000-0002-7260-8811
Guillem Sánchez, María Salud|||0000-0001-5660-3693
author2_role author
author
author
author
dc.contributor.none.fl_str_mv Departamento de Ingeniería Electrónica
Escuela Técnica Superior de Ingeniería de Telecomunicación
Instituto Universitario de Tecnologías de la Información y Comunicaciones
Departamento de Estadística e Investigación Operativa Aplicadas y Calidad
Escuela Técnica Superior de Ingeniería Aeroespacial y Diseño Industrial
Escuela Técnica Superior de Ingeniería Industrial
Generalitat Valenciana
Instituto de Salud Carlos III
European Regional Development Fund
Ministerio de Ciencia, Innovación y Universidades
Repositorio Institucional de la Universitat Politècnica de València Riunet
dc.subject.none.fl_str_mv Atrial fibrillation
Electrocardiographic imaging
Reproducibility
Reentrant activity
Pulmonary vein isolation
TECNOLOGIA ELECTRONICA
ESTADISTICA E INVESTIGACION OPERATIVA
topic Atrial fibrillation
Electrocardiographic imaging
Reproducibility
Reentrant activity
Pulmonary vein isolation
TECNOLOGIA ELECTRONICA
ESTADISTICA E INVESTIGACION OPERATIVA
description [EN] Background: Electrocardiographic imaging (ECGI) allows evaluating the complexity of the reentrant activity of atrial fibrillation (AF) patients. In this study, we evaluated the ability of ECGI metrics to predict the success of pulmonary vein isolation (PVI) to treat AF. Methods: ECGI of 24 AF patients (6 males, 13 paroxysmal, 61.8 +/- 14 years) was recorded prior to PVI. Patients were distributed into two groups based on their PVI outcome 6 months after ablation (sinus vs. arrhythmia recurrence). Metrics derived from phase analysis of ECGI signals were computed for two different temporal segments before ablation. Correlation analysis and variability over time were studied between the two recorded segments and were compared between patient groups. Results: Temporal variability of both rotor duration and spatial entropy of the rotor histogram presented statistical differences between groups with different PVI outcome (p < 0.05). The reproducibility of reentrant metrics was higher (R-2 > 0.8) in patients with good outcome rather than arrhythmia recurrence patients (R-2 < 0.62). Prediction of PVI success based on ECGI temporal variability metrics allows for an increased specificity over the classification into paroxysmal or persistent (0.85 vs. 0.64). Conclusions: Patients with favorable PVI outcome present ECGI metrics more reproducible over time than patients with AF recurrence. These results suggest that ECGI derived metrics may allow selecting which patients would benefit from ablation therapies.
publishDate 2021
dc.date.none.fl_str_mv 2021
2021-12-01
dc.type.none.fl_str_mv journal article
http://purl.org/coar/resource_type/c_6501
VoR
http://purl.org/coar/version/c_970fb48d4fbd8a85
dc.type.openaire.fl_str_mv info:eu-repo/semantics/article
format article
dc.identifier.none.fl_str_mv https://riunet.upv.es/handle/10251/183953
url https://riunet.upv.es/handle/10251/183953
dc.language.none.fl_str_mv Inglés
eng
language_invalid_str_mv Inglés
language eng
dc.relation.none.fl_str_mv Ministerio de Ciencia, Innovación y Universidades https://doi.org/10.13039/100014440 RYC2018-024346-I
Generalitat Valenciana https://doi.org/10.13039/501100003359 ACIF%2F2020%2F265
European Regional Development Fund https://doi.org/10.13039/501100008530 EITHealth 19600 AFFINE
Instituto de Salud Carlos III https://doi.org/10.13039/501100004587 PI17%2F01106
dc.rights.none.fl_str_mv open access
http://purl.org/coar/access_right/c_abf2
Reconocimiento - No comercial - Sin obra derivada (by-nc-nd)
http://creativecommons.org/licenses/by-nc-nd/4.0/
dc.rights.openaire.fl_str_mv info:eu-repo/semantics/openAccess
rights_invalid_str_mv open access
http://purl.org/coar/access_right/c_abf2
Reconocimiento - No comercial - Sin obra derivada (by-nc-nd)
http://creativecommons.org/licenses/by-nc-nd/4.0/
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
application/pdf
dc.publisher.none.fl_str_mv Elsevier
publisher.none.fl_str_mv Elsevier
dc.source.none.fl_str_mv reponame:RiuNet. Repositorio Institucional de la Universitat Politécnica de Valéncia
instname:Universitat Politècnica de València (UPV)
instname_str Universitat Politècnica de València (UPV)
reponame_str RiuNet. Repositorio Institucional de la Universitat Politécnica de Valéncia
collection RiuNet. Repositorio Institucional de la Universitat Politécnica de Valéncia
repository.name.fl_str_mv
repository.mail.fl_str_mv
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score 15.300719

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