Technological advances in ocular trabecular meshwork in vitro models for glaucoma research.

Glaucoma is the leading cause of irreversible blindness worldwide and ischaracterized by the progressive degeneration of the optic nerve. Intraocularpressure (IOP), which is considered to be the main risk factor for glaucomadevelopment, builds up in response to the resistance (resistance to what?) p...

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Authors: Bikuna-Izagirre, M. (María)|||/items/86b0a5cd-3d8b-44a5-a21f-f9d6617af1af, Aldazabal, J. (Javier)|||/items/20826650-7987-4914-8b0c-70e37bb5b281, Extramiana, L. (Leire)|||/items/f11a84dc-d222-4fa9-828f-4260e99beaeb, Moreno-Montañes, J. (Javier)|||/items/98d37454-a942-4359-9367-75c9948f0834, Carnero, E. (Elena)|||/items/0270d018-997a-4a86-a675-079b99a00528
Format: article
Publication Date:2022
Country:España
Institution:Universidad de Navarra
Repository:Dadun. Depósito Académico Digital de la Universidad de Navarra
Language:English
OAI Identifier:oai:dadun.unav.edu:10171/69998
Online Access:https://hdl.handle.net/10171/69998
Access Level:Open access
Keyword:Aqueous humor outflow.
Glaucoma.
Scaffolds.
Trabecular meshwork.
Tissue‐engineering.
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spelling Technological advances in ocular trabecular meshwork in vitro models for glaucoma research.Bikuna-Izagirre, M. (María)|||/items/86b0a5cd-3d8b-44a5-a21f-f9d6617af1afAldazabal, J. (Javier)|||/items/20826650-7987-4914-8b0c-70e37bb5b281Extramiana, L. (Leire)|||/items/f11a84dc-d222-4fa9-828f-4260e99beaebMoreno-Montañes, J. (Javier)|||/items/98d37454-a942-4359-9367-75c9948f0834Carnero, E. (Elena)|||/items/0270d018-997a-4a86-a675-079b99a00528Aqueous humor outflow.Glaucoma.Scaffolds.Trabecular meshwork.Tissue‐engineering.Glaucoma is the leading cause of irreversible blindness worldwide and ischaracterized by the progressive degeneration of the optic nerve. Intraocularpressure (IOP), which is considered to be the main risk factor for glaucomadevelopment, builds up in response to the resistance (resistance to what?) providedby the trabecular meshwork (TM) to aqueous humor (AH) outflow. Although the TMand its relationship to AH outflow have remained at the forefront of scientificinterest, researchers remain uncertain regarding which mechanisms drive thedeterioration of the TM. Current tissue‐engineering fabrication techniques havecome up with promising approaches to successfully recreate the TM. Nonetheless,more accurate models are needed to understand the factors that make glaucomaarise. In this review, we provide a chronological evaluation of the technologicalmilestones that have taken place in the field of glaucoma research, and we conduct acomprehensive comparison of available TM fabrication technologies. Additionally,we also discuss AH perfusion platforms, since they are essential for the validation ofthese scaffolds, as well as pressure–outflow relationship studies and the discovery ofnew IOP‐reduction therapies.WileyDadun. Depósito Académico Digital Universidad de Navarra20242024-09-2720222022-01-0120222022-01-01journal articlehttp://purl.org/coar/resource_type/c_6501info:eu-repo/semantics/articleapplication/pdfhttps://hdl.handle.net/10171/69998reponame:Dadun. Depósito Académico Digital de la Universidad de Navarrainstname:Universidad de NavarraInglésengopen accesshttp://purl.org/coar/access_right/c_abf2info:eu-repo/semantics/openAccessoai:dadun.unav.edu:10171/699982026-06-21T12:47:57Z
dc.title.none.fl_str_mv Technological advances in ocular trabecular meshwork in vitro models for glaucoma research.
title Technological advances in ocular trabecular meshwork in vitro models for glaucoma research.
spellingShingle Technological advances in ocular trabecular meshwork in vitro models for glaucoma research.
Bikuna-Izagirre, M. (María)|||/items/86b0a5cd-3d8b-44a5-a21f-f9d6617af1af
Aqueous humor outflow.
Glaucoma.
Scaffolds.
Trabecular meshwork.
Tissue‐engineering.
title_short Technological advances in ocular trabecular meshwork in vitro models for glaucoma research.
title_full Technological advances in ocular trabecular meshwork in vitro models for glaucoma research.
title_fullStr Technological advances in ocular trabecular meshwork in vitro models for glaucoma research.
title_full_unstemmed Technological advances in ocular trabecular meshwork in vitro models for glaucoma research.
title_sort Technological advances in ocular trabecular meshwork in vitro models for glaucoma research.
dc.creator.none.fl_str_mv Bikuna-Izagirre, M. (María)|||/items/86b0a5cd-3d8b-44a5-a21f-f9d6617af1af
Aldazabal, J. (Javier)|||/items/20826650-7987-4914-8b0c-70e37bb5b281
Extramiana, L. (Leire)|||/items/f11a84dc-d222-4fa9-828f-4260e99beaeb
Moreno-Montañes, J. (Javier)|||/items/98d37454-a942-4359-9367-75c9948f0834
Carnero, E. (Elena)|||/items/0270d018-997a-4a86-a675-079b99a00528
author Bikuna-Izagirre, M. (María)|||/items/86b0a5cd-3d8b-44a5-a21f-f9d6617af1af
author_facet Bikuna-Izagirre, M. (María)|||/items/86b0a5cd-3d8b-44a5-a21f-f9d6617af1af
Aldazabal, J. (Javier)|||/items/20826650-7987-4914-8b0c-70e37bb5b281
Extramiana, L. (Leire)|||/items/f11a84dc-d222-4fa9-828f-4260e99beaeb
Moreno-Montañes, J. (Javier)|||/items/98d37454-a942-4359-9367-75c9948f0834
Carnero, E. (Elena)|||/items/0270d018-997a-4a86-a675-079b99a00528
author_role author
author2 Aldazabal, J. (Javier)|||/items/20826650-7987-4914-8b0c-70e37bb5b281
Extramiana, L. (Leire)|||/items/f11a84dc-d222-4fa9-828f-4260e99beaeb
Moreno-Montañes, J. (Javier)|||/items/98d37454-a942-4359-9367-75c9948f0834
Carnero, E. (Elena)|||/items/0270d018-997a-4a86-a675-079b99a00528
author2_role author
author
author
author
dc.contributor.none.fl_str_mv Dadun. Depósito Académico Digital Universidad de Navarra
dc.subject.none.fl_str_mv Aqueous humor outflow.
Glaucoma.
Scaffolds.
Trabecular meshwork.
Tissue‐engineering.
topic Aqueous humor outflow.
Glaucoma.
Scaffolds.
Trabecular meshwork.
Tissue‐engineering.
description Glaucoma is the leading cause of irreversible blindness worldwide and ischaracterized by the progressive degeneration of the optic nerve. Intraocularpressure (IOP), which is considered to be the main risk factor for glaucomadevelopment, builds up in response to the resistance (resistance to what?) providedby the trabecular meshwork (TM) to aqueous humor (AH) outflow. Although the TMand its relationship to AH outflow have remained at the forefront of scientificinterest, researchers remain uncertain regarding which mechanisms drive thedeterioration of the TM. Current tissue‐engineering fabrication techniques havecome up with promising approaches to successfully recreate the TM. Nonetheless,more accurate models are needed to understand the factors that make glaucomaarise. In this review, we provide a chronological evaluation of the technologicalmilestones that have taken place in the field of glaucoma research, and we conduct acomprehensive comparison of available TM fabrication technologies. Additionally,we also discuss AH perfusion platforms, since they are essential for the validation ofthese scaffolds, as well as pressure–outflow relationship studies and the discovery ofnew IOP‐reduction therapies.
publishDate 2022
dc.date.none.fl_str_mv 2022
2022-01-01
2022
2022-01-01
2024
2024-09-27
dc.type.none.fl_str_mv journal article
http://purl.org/coar/resource_type/c_6501
dc.type.openaire.fl_str_mv info:eu-repo/semantics/article
format article
dc.identifier.none.fl_str_mv https://hdl.handle.net/10171/69998
url https://hdl.handle.net/10171/69998
dc.language.none.fl_str_mv Inglés
eng
language_invalid_str_mv Inglés
language eng
dc.rights.none.fl_str_mv open access
http://purl.org/coar/access_right/c_abf2
dc.rights.openaire.fl_str_mv info:eu-repo/semantics/openAccess
rights_invalid_str_mv open access
http://purl.org/coar/access_right/c_abf2
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv Wiley
publisher.none.fl_str_mv Wiley
dc.source.none.fl_str_mv reponame:Dadun. Depósito Académico Digital de la Universidad de Navarra
instname:Universidad de Navarra
instname_str Universidad de Navarra
reponame_str Dadun. Depósito Académico Digital de la Universidad de Navarra
collection Dadun. Depósito Académico Digital de la Universidad de Navarra
repository.name.fl_str_mv
repository.mail.fl_str_mv
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