Microvesicles: ROS scavengers and ROS producers

This review analyzes the relationship between microvesicles and reactive oxygen species (ROS). This relationship is bidirectional; on the one hand, the number and content of microvesicles produced by the cells are affected by oxidative stress conditions; on the other hand, microvesicles can directly...

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Detalles Bibliográficos
Autores: Bodega Magro, Guillermo|||0000-0003-1469-3242, Alique Aguilar, Matilde|||0000-0002-7912-1133, Puebla Jiménez, Lilian|||0000-0002-0681-3235, Carracedo, Julia, Ramírez Chamond, Manuel Rafael|||0000-0003-4598-339X
Tipo de recurso: artículo
Fecha de publicación:2019
País:España
Institución:Universidad de Alcalá (UAH)
Repositorio:e_Buah Biblioteca Digital Universidad de Alcalá
Idioma:inglés
OAI Identifier:oai:ebuah.uah.es:10017/64115
Acceso en línea:http://hdl.handle.net/10017/64115
https://dx.doi.org/10.1080/20013078.2019.1626654
Access Level:acceso abierto
Palabra clave:Extracellular vesicles
Microvesicles
Reactive oxygen species
Medicina
Medicine
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spelling Microvesicles: ROS scavengers and ROS producersBodega Magro, Guillermo|||0000-0003-1469-3242Alique Aguilar, Matilde|||0000-0002-7912-1133Puebla Jiménez, Lilian|||0000-0002-0681-3235Carracedo, JuliaRamírez Chamond, Manuel Rafael|||0000-0003-4598-339XExtracellular vesiclesMicrovesiclesReactive oxygen speciesMedicinaMedicineThis review analyzes the relationship between microvesicles and reactive oxygen species (ROS). This relationship is bidirectional; on the one hand, the number and content of microvesicles produced by the cells are affected by oxidative stress conditions; on the other hand, microvesicles can directly and/or indirectly modify the ROS content in the extra- as well as the intracellular compartments. In this regard, microvesicles contain a pro-oxidant or antioxidant machinery that may produce or scavenge ROS: direct effect. This mechanism is especially suitable for eliminating ROS in the extracellular compartment. Endothelial microvesicles, in particular, contain a specific and well-developed antioxidant machinery. On the other hand, the molecules included in microvesicles can modify (activate or inhibit) ROS metabolism in their target cells: indirect effect. This can be achieved by the incorporation into the cells of ROS metabolic enzymes included in the microvesicles, or by the regulation of signaling pathways involved in ROS metabolism. Proteins, as well as miRNAs, are involved in this last effect.20192019-06-17journal articlehttp://purl.org/coar/resource_type/c_6501NAhttp://purl.org/coar/version/c_be7fb7dd8ff6fe43info:eu-repo/semantics/articleapplication/pdfhttp://hdl.handle.net/10017/64115https://dx.doi.org/10.1080/20013078.2019.1626654reponame:e_Buah Biblioteca Digital Universidad de Alcaláinstname:Universidad de Alcalá (UAH)Inglésengopen accesshttp://purl.org/coar/access_right/c_abf2Attribution-NonCommercial-NoDerivatives 4.0 Internationalhttp://creativecommons.org/licenses/by-nc-nd/4.0/info:eu-repo/semantics/openAccessoai:ebuah.uah.es:10017/641152026-06-18T11:13:07Z
dc.title.none.fl_str_mv Microvesicles: ROS scavengers and ROS producers
title Microvesicles: ROS scavengers and ROS producers
spellingShingle Microvesicles: ROS scavengers and ROS producers
Bodega Magro, Guillermo|||0000-0003-1469-3242
Extracellular vesicles
Microvesicles
Reactive oxygen species
Medicina
Medicine
title_short Microvesicles: ROS scavengers and ROS producers
title_full Microvesicles: ROS scavengers and ROS producers
title_fullStr Microvesicles: ROS scavengers and ROS producers
title_full_unstemmed Microvesicles: ROS scavengers and ROS producers
title_sort Microvesicles: ROS scavengers and ROS producers
dc.creator.none.fl_str_mv Bodega Magro, Guillermo|||0000-0003-1469-3242
Alique Aguilar, Matilde|||0000-0002-7912-1133
Puebla Jiménez, Lilian|||0000-0002-0681-3235
Carracedo, Julia
Ramírez Chamond, Manuel Rafael|||0000-0003-4598-339X
author Bodega Magro, Guillermo|||0000-0003-1469-3242
author_facet Bodega Magro, Guillermo|||0000-0003-1469-3242
Alique Aguilar, Matilde|||0000-0002-7912-1133
Puebla Jiménez, Lilian|||0000-0002-0681-3235
Carracedo, Julia
Ramírez Chamond, Manuel Rafael|||0000-0003-4598-339X
author_role author
author2 Alique Aguilar, Matilde|||0000-0002-7912-1133
Puebla Jiménez, Lilian|||0000-0002-0681-3235
Carracedo, Julia
Ramírez Chamond, Manuel Rafael|||0000-0003-4598-339X
author2_role author
author
author
author
dc.subject.none.fl_str_mv Extracellular vesicles
Microvesicles
Reactive oxygen species
Medicina
Medicine
topic Extracellular vesicles
Microvesicles
Reactive oxygen species
Medicina
Medicine
description This review analyzes the relationship between microvesicles and reactive oxygen species (ROS). This relationship is bidirectional; on the one hand, the number and content of microvesicles produced by the cells are affected by oxidative stress conditions; on the other hand, microvesicles can directly and/or indirectly modify the ROS content in the extra- as well as the intracellular compartments. In this regard, microvesicles contain a pro-oxidant or antioxidant machinery that may produce or scavenge ROS: direct effect. This mechanism is especially suitable for eliminating ROS in the extracellular compartment. Endothelial microvesicles, in particular, contain a specific and well-developed antioxidant machinery. On the other hand, the molecules included in microvesicles can modify (activate or inhibit) ROS metabolism in their target cells: indirect effect. This can be achieved by the incorporation into the cells of ROS metabolic enzymes included in the microvesicles, or by the regulation of signaling pathways involved in ROS metabolism. Proteins, as well as miRNAs, are involved in this last effect.
publishDate 2019
dc.date.none.fl_str_mv 2019
2019-06-17
dc.type.none.fl_str_mv journal article
http://purl.org/coar/resource_type/c_6501
NA
http://purl.org/coar/version/c_be7fb7dd8ff6fe43
dc.type.openaire.fl_str_mv info:eu-repo/semantics/article
format article
dc.identifier.none.fl_str_mv http://hdl.handle.net/10017/64115
https://dx.doi.org/10.1080/20013078.2019.1626654
url http://hdl.handle.net/10017/64115
https://dx.doi.org/10.1080/20013078.2019.1626654
dc.language.none.fl_str_mv Inglés
eng
language_invalid_str_mv Inglés
language eng
dc.rights.none.fl_str_mv open access
http://purl.org/coar/access_right/c_abf2
Attribution-NonCommercial-NoDerivatives 4.0 International
http://creativecommons.org/licenses/by-nc-nd/4.0/
dc.rights.openaire.fl_str_mv info:eu-repo/semantics/openAccess
rights_invalid_str_mv open access
http://purl.org/coar/access_right/c_abf2
Attribution-NonCommercial-NoDerivatives 4.0 International
http://creativecommons.org/licenses/by-nc-nd/4.0/
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.source.none.fl_str_mv reponame:e_Buah Biblioteca Digital Universidad de Alcalá
instname:Universidad de Alcalá (UAH)
instname_str Universidad de Alcalá (UAH)
reponame_str e_Buah Biblioteca Digital Universidad de Alcalá
collection e_Buah Biblioteca Digital Universidad de Alcalá
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