Soluble fms-like tyrosine kinase to placental growth factor ratio in different stages of early-onset fetal growth restriction and small for gestational age

Introduction: Increased soluble fms-like tyrosine kinase to placental growth factor ratio (sFlt-1/PlGF) has been demonstrated in early-onset fetal growth restriction (FGR) and small for gestational age (SGA). sFlt-1/PlGF cut-offs have been described to assess preeclampsia severity; however, sFlt-1/P...

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Autores: García Manau, Pablo, Mendoza, Manel|||0000-0002-3030-3833, Bonacina, Erika|||0000-0002-8042-8247, Garrido-Giménez, Carmen|||0000-0003-2180-1715, Fernández-Oliva, Antonio|||0000-0002-8610-2600, Zanini, Julia|||0000-0002-6006-7595, Catalan, Marina, Tur, Helena, Serrano, Berta|||0000-0002-1264-9195, Carreras Moratonas, Elena|||0000-0003-3471-7248
Tipo de recurso: artículo
Fecha de publicación:2021
País:España
Institución:Universitat Autònoma de Barcelona
Repositorio:Dipòsit Digital de Documents de la UAB
Idioma:inglés
OAI Identifier:oai:ddd.uab.cat:310250
Acceso en línea:https://ddd.uab.cat/record/310250
https://dx.doi.org/urn:doi:10.1111/aogs.13978
Access Level:acceso abierto
Palabra clave:Adverse pregnancy outcomes
Angiogenic factors
FGR
PlGF
Sflt-1
SGA
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spelling Soluble fms-like tyrosine kinase to placental growth factor ratio in different stages of early-onset fetal growth restriction and small for gestational ageGarcía Manau, PabloMendoza, Manel|||0000-0002-3030-3833Bonacina, Erika|||0000-0002-8042-8247Garrido-Giménez, Carmen|||0000-0003-2180-1715Fernández-Oliva, Antonio|||0000-0002-8610-2600Zanini, Julia|||0000-0002-6006-7595Catalan, MarinaTur, HelenaSerrano, Berta|||0000-0002-1264-9195Carreras Moratonas, Elena|||0000-0003-3471-7248Adverse pregnancy outcomesAngiogenic factorsFGRPlGFSflt-1SGAIntroduction: Increased soluble fms-like tyrosine kinase to placental growth factor ratio (sFlt-1/PlGF) has been demonstrated in early-onset fetal growth restriction (FGR) and small for gestational age (SGA). sFlt-1/PlGF cut-offs have been described to assess preeclampsia severity; however, sFlt-1/PlGF values present in early-onset SGA and different FGR severity stages remain unknown. Hence, the objective of this study was to describe and compare the sFlt-1/PlGF values and pregnancy outcomes among early-onset SGA/FGR stages. Material and methods: This is a prospective case-control study conducted at Vall d'Hebron University Hospital. Singleton pregnancies with estimated fetal weight <10th centile and a control group of uncomplicated pregnancies between 20 and 31 weeks of gestation were enrolled. Study women were classified at diagnosis into different stages, according to estimated fetal weight centile and Doppler ultrasound. sFlt-1/PlGF serum concentrations were measured at diagnosis and, together with pregnancy outcomes, were compared among FGR severity stages, SGA, and controls. Finally, correlations between sFlt-1/PlGF values and time to delivery, gestational age at delivery, days of neonatal admission, and birthweight z-scores were investigated. Results: Among the 207 women enrolled, 32 (15.4%) had uncomplicated pregnancies, 49 (23.7%) pregnancies showed SGA, and 126 (60.9%) involved FGR (92 being stage I, 17 stage II, and 17 stage III). SGA and controls had similar median sFlt-1/PlGF values (25.7 vs 27.1, P.Universitat Autònoma de Barcelona. Departament de Pediatria, Obstetrícia i Ginecologia i de Medicina Preventiva i Salut Pública 22021-01-0120212021-01-01Articlehttp://purl.org/coar/resource_type/c_6501AMhttp://purl.org/coar/version/c_ab4af688f83e57aainfo:eu-repo/semantics/articleapplication/pdfhttps://ddd.uab.cat/record/310250https://dx.doi.org/urn:doi:10.1111/aogs.13978reponame:Dipòsit Digital de Documents de la UABinstname:Universitat Autònoma de BarcelonaInglésengopen accesshttp://purl.org/coar/access_right/c_abf2Aquest material està protegit per drets d'autor i/o drets afins. Podeu utilitzar aquest material en funció del que permet la legislació de drets d'autor i drets afins d'aplicació al vostre cas. Per a d'altres usos heu d'obtenir permís del(s) titular(s) de drets.https://rightsstatements.org/vocab/InC/1.0/info:eu-repo/semantics/openAccessoai:ddd.uab.cat:3102502026-06-06T12:50:31Z
dc.title.none.fl_str_mv Soluble fms-like tyrosine kinase to placental growth factor ratio in different stages of early-onset fetal growth restriction and small for gestational age
title Soluble fms-like tyrosine kinase to placental growth factor ratio in different stages of early-onset fetal growth restriction and small for gestational age
spellingShingle Soluble fms-like tyrosine kinase to placental growth factor ratio in different stages of early-onset fetal growth restriction and small for gestational age
García Manau, Pablo
Adverse pregnancy outcomes
Angiogenic factors
FGR
PlGF
Sflt-1
SGA
title_short Soluble fms-like tyrosine kinase to placental growth factor ratio in different stages of early-onset fetal growth restriction and small for gestational age
title_full Soluble fms-like tyrosine kinase to placental growth factor ratio in different stages of early-onset fetal growth restriction and small for gestational age
title_fullStr Soluble fms-like tyrosine kinase to placental growth factor ratio in different stages of early-onset fetal growth restriction and small for gestational age
title_full_unstemmed Soluble fms-like tyrosine kinase to placental growth factor ratio in different stages of early-onset fetal growth restriction and small for gestational age
title_sort Soluble fms-like tyrosine kinase to placental growth factor ratio in different stages of early-onset fetal growth restriction and small for gestational age
dc.creator.none.fl_str_mv García Manau, Pablo
Mendoza, Manel|||0000-0002-3030-3833
Bonacina, Erika|||0000-0002-8042-8247
Garrido-Giménez, Carmen|||0000-0003-2180-1715
Fernández-Oliva, Antonio|||0000-0002-8610-2600
Zanini, Julia|||0000-0002-6006-7595
Catalan, Marina
Tur, Helena
Serrano, Berta|||0000-0002-1264-9195
Carreras Moratonas, Elena|||0000-0003-3471-7248
author García Manau, Pablo
author_facet García Manau, Pablo
Mendoza, Manel|||0000-0002-3030-3833
Bonacina, Erika|||0000-0002-8042-8247
Garrido-Giménez, Carmen|||0000-0003-2180-1715
Fernández-Oliva, Antonio|||0000-0002-8610-2600
Zanini, Julia|||0000-0002-6006-7595
Catalan, Marina
Tur, Helena
Serrano, Berta|||0000-0002-1264-9195
Carreras Moratonas, Elena|||0000-0003-3471-7248
author_role author
author2 Mendoza, Manel|||0000-0002-3030-3833
Bonacina, Erika|||0000-0002-8042-8247
Garrido-Giménez, Carmen|||0000-0003-2180-1715
Fernández-Oliva, Antonio|||0000-0002-8610-2600
Zanini, Julia|||0000-0002-6006-7595
Catalan, Marina
Tur, Helena
Serrano, Berta|||0000-0002-1264-9195
Carreras Moratonas, Elena|||0000-0003-3471-7248
author2_role author
author
author
author
author
author
author
author
author
dc.contributor.none.fl_str_mv Universitat Autònoma de Barcelona. Departament de Pediatria, Obstetrícia i Ginecologia i de Medicina Preventiva i Salut Pública
dc.subject.none.fl_str_mv Adverse pregnancy outcomes
Angiogenic factors
FGR
PlGF
Sflt-1
SGA
topic Adverse pregnancy outcomes
Angiogenic factors
FGR
PlGF
Sflt-1
SGA
description Introduction: Increased soluble fms-like tyrosine kinase to placental growth factor ratio (sFlt-1/PlGF) has been demonstrated in early-onset fetal growth restriction (FGR) and small for gestational age (SGA). sFlt-1/PlGF cut-offs have been described to assess preeclampsia severity; however, sFlt-1/PlGF values present in early-onset SGA and different FGR severity stages remain unknown. Hence, the objective of this study was to describe and compare the sFlt-1/PlGF values and pregnancy outcomes among early-onset SGA/FGR stages. Material and methods: This is a prospective case-control study conducted at Vall d'Hebron University Hospital. Singleton pregnancies with estimated fetal weight <10th centile and a control group of uncomplicated pregnancies between 20 and 31 weeks of gestation were enrolled. Study women were classified at diagnosis into different stages, according to estimated fetal weight centile and Doppler ultrasound. sFlt-1/PlGF serum concentrations were measured at diagnosis and, together with pregnancy outcomes, were compared among FGR severity stages, SGA, and controls. Finally, correlations between sFlt-1/PlGF values and time to delivery, gestational age at delivery, days of neonatal admission, and birthweight z-scores were investigated. Results: Among the 207 women enrolled, 32 (15.4%) had uncomplicated pregnancies, 49 (23.7%) pregnancies showed SGA, and 126 (60.9%) involved FGR (92 being stage I, 17 stage II, and 17 stage III). SGA and controls had similar median sFlt-1/PlGF values (25.7 vs 27.1, P.
publishDate 2021
dc.date.none.fl_str_mv 2
2021-01-01
2021
2021-01-01
dc.type.none.fl_str_mv Article
http://purl.org/coar/resource_type/c_6501
AM
http://purl.org/coar/version/c_ab4af688f83e57aa
dc.type.openaire.fl_str_mv info:eu-repo/semantics/article
format article
dc.identifier.none.fl_str_mv https://ddd.uab.cat/record/310250
https://dx.doi.org/urn:doi:10.1111/aogs.13978
url https://ddd.uab.cat/record/310250
https://dx.doi.org/urn:doi:10.1111/aogs.13978
dc.language.none.fl_str_mv Inglés
eng
language_invalid_str_mv Inglés
language eng
dc.rights.none.fl_str_mv open access
http://purl.org/coar/access_right/c_abf2
https://rightsstatements.org/vocab/InC/1.0/
dc.rights.openaire.fl_str_mv info:eu-repo/semantics/openAccess
rights_invalid_str_mv open access
http://purl.org/coar/access_right/c_abf2
https://rightsstatements.org/vocab/InC/1.0/
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.source.none.fl_str_mv reponame:Dipòsit Digital de Documents de la UAB
instname:Universitat Autònoma de Barcelona
instname_str Universitat Autònoma de Barcelona
reponame_str Dipòsit Digital de Documents de la UAB
collection Dipòsit Digital de Documents de la UAB
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