The role of microRNAs in understanding sex-based differences in Alzheimer s disease
[EN] Background: The incidence of Alzheimer's disease (AD)-the most frequent cause of dementia-is expected to increase as life expectancies rise across the globe. While sex-based differences in AD have previously been described, there remain uncertainties regarding any association between s...
| Autores: | , , , , , , , , , , , , , |
|---|---|
| Formato: | artículo |
| Fecha de publicación: | 2024 |
| País: | España |
| Recursos: | Universitat Politècnica de València (UPV) |
| Repositorio: | RiuNet. Repositorio Institucional de la Universitat Politécnica de Valéncia |
| Idioma: | inglés |
| OAI Identifier: | oai:riunet.upv.es:10251/221269 |
| Acesso em linha: | https://riunet.upv.es/handle/10251/221269 |
| Access Level: | acceso abierto |
| Palavra-chave: | Sex-based differences Alzheimer&apos s disease Biomarkers Systematic review Meta-analysis Transcriptomics MicroRNAs 03.- Garantizar una vida saludable y promover el bienestar para todos y todas en todas las edades |
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España |
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| dc.title.none.fl_str_mv |
The role of microRNAs in understanding sex-based differences in Alzheimer s disease |
| title |
The role of microRNAs in understanding sex-based differences in Alzheimer s disease |
| spellingShingle |
The role of microRNAs in understanding sex-based differences in Alzheimer s disease Llera&#8209 Sex-based differences Alzheimer&apos s disease Biomarkers Systematic review Meta-analysis Transcriptomics MicroRNAs 03.- Garantizar una vida saludable y promover el bienestar para todos y todas en todas las edades |
| title_short |
The role of microRNAs in understanding sex-based differences in Alzheimer s disease |
| title_full |
The role of microRNAs in understanding sex-based differences in Alzheimer s disease |
| title_fullStr |
The role of microRNAs in understanding sex-based differences in Alzheimer s disease |
| title_full_unstemmed |
The role of microRNAs in understanding sex-based differences in Alzheimer s disease |
| title_sort |
The role of microRNAs in understanding sex-based differences in Alzheimer s disease |
| dc.creator.none.fl_str_mv |
Llera&#8209 Oyola, Jaime Carceller, Héctor Andreu, Zoraida Hidalgo, Marta R. Soler-Sáez, Irene Gordillo-González, Fernando Gómez-Cabañes, Borja Rosón, Beatriz Mancuso, Roberta Guerini, Franca R. Mizokami, Akiko García-García, Francisco DE LA IGLESIA VAYÁ, MARIA DE LOS DESAMPARADOS |
| author |
Llera&#8209 |
| author_facet |
Llera&#8209 Oyola, Jaime Carceller, Héctor Andreu, Zoraida Hidalgo, Marta R. Soler-Sáez, Irene Gordillo-González, Fernando Gómez-Cabañes, Borja Rosón, Beatriz Mancuso, Roberta Guerini, Franca R. Mizokami, Akiko García-García, Francisco DE LA IGLESIA VAYÁ, MARIA DE LOS DESAMPARADOS |
| author_role |
author |
| author2 |
Oyola, Jaime Carceller, Héctor Andreu, Zoraida Hidalgo, Marta R. Soler-Sáez, Irene Gordillo-González, Fernando Gómez-Cabañes, Borja Rosón, Beatriz Mancuso, Roberta Guerini, Franca R. Mizokami, Akiko García-García, Francisco DE LA IGLESIA VAYÁ, MARIA DE LOS DESAMPARADOS |
| author2_role |
author author author author author author author author author author author author author |
| dc.contributor.none.fl_str_mv |
Instituto de Salud Carlos III Ministerio de Educación y Ciencia Repositorio Institucional de la Universitat Politècnica de València Riunet |
| dc.subject.none.fl_str_mv |
Sex-based differences Alzheimer&apos s disease Biomarkers Systematic review Meta-analysis Transcriptomics MicroRNAs 03.- Garantizar una vida saludable y promover el bienestar para todos y todas en todas las edades |
| topic |
Sex-based differences Alzheimer&apos s disease Biomarkers Systematic review Meta-analysis Transcriptomics MicroRNAs 03.- Garantizar una vida saludable y promover el bienestar para todos y todas en todas las edades |
| description |
[EN] Background: The incidence of Alzheimer's disease (AD)-the most frequent cause of dementia-is expected to increase as life expectancies rise across the globe. While sex-based differences in AD have previously been described, there remain uncertainties regarding any association between sex and disease-associated molecular mechanisms. Studying sex-specific expression profiles of regulatory factors such as microRNAs (miRNAs) could contribute to more accurate disease diagnosis and treatment.Methods: A systematic review identified six studies of microRNA expression in AD patients that incorporated information regarding the biological sex of samples in the Gene Expression Omnibus repository. A differential microRNA expression analysis was performed, considering disease status and patient sex. Subsequently, results were integrated within a meta-analysis methodology, with a functional enrichment of meta-analysis results establishing an association between altered miRNA expression and relevant Gene Ontology terms.Results: Meta-analyses of miRNA expression profiles in blood samples revealed the alteration of sixteen miRNAs in female and 22 miRNAs in male AD patients. We discovered nine miRNAs commonly overexpressed in both sexes, suggesting a shared miRNA dysregulation profile. Functional enrichment results based on miRNA profiles revealed sex-based differences in biological processes; most affected processes related to ubiquitination, regulation of different kinase activities, and apoptotic processes in males, but RNA splicing and translation in females. Meta-analyses of miRNA expression profiles in brain samples revealed the alteration of six miRNAs in female and four miRNAs in male AD patients. We observed a single underexpressed miRNA in female and male AD patients (hsa-miR-767-5p); however, the functional enrichment analysis for brain samples did not reveal any specifically affected biological process.Conclusions: Sex-specific meta-analyses supported the detection of differentially expressed miRNAs in female and male AD patients, highlighting the relevance of sex-based information in biomedical data. Further studies on miRNA regulation in AD patients should meet the criteria for comparability and standardization of information. |
| publishDate |
2024 |
| dc.date.none.fl_str_mv |
2024 2024-01-31 |
| dc.type.none.fl_str_mv |
journal article http://purl.org/coar/resource_type/c_6501 VoR http://purl.org/coar/version/c_970fb48d4fbd8a85 |
| dc.type.openaire.fl_str_mv |
info:eu-repo/semantics/article |
| format |
article |
| dc.identifier.none.fl_str_mv |
https://riunet.upv.es/handle/10251/221269 |
| url |
https://riunet.upv.es/handle/10251/221269 |
| dc.language.none.fl_str_mv |
Inglés eng |
| language_invalid_str_mv |
Inglés |
| language |
eng |
| dc.relation.none.fl_str_mv |
Agencia Estatal de Investigación http://dx.doi.org/10.13039/501100011033 Plan Estatal de Investigación Científica y Técnica y de Innovación 2021-2023 PID2021-124430OA-I00 ESTUDIO DE LAS DIFERENCIAS DE SEXO EN ENFERMEDADES NEURODEGENERATIVAS CON ABORDAJES INTEGRATIVOS DE DATOS OMICOS E IMAGEN BIOMEDICA Instituto de Salud Carlos III https://doi.org/10.13039/501100004587 IMP%2F00019 Ministerio de Educación y Ciencia https://doi.org/10.13039/501100008743 MS21-074 Ministerio de Educación y Ciencia https://doi.org/10.13039/501100008743 PID2021-124430OA-I00 PROYECTOS DE GENERACIÓN DE CONOCIMIENTO, Convocatoria 2021 |
| dc.rights.none.fl_str_mv |
open access http://purl.org/coar/access_right/c_abf2 Reconocimiento (by) http://creativecommons.org/licenses/by/4.0/ |
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info:eu-repo/semantics/openAccess |
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open access http://purl.org/coar/access_right/c_abf2 Reconocimiento (by) http://creativecommons.org/licenses/by/4.0/ |
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openAccess |
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application/pdf |
| dc.publisher.none.fl_str_mv |
Springer (Biomed Central Ltd.) |
| publisher.none.fl_str_mv |
Springer (Biomed Central Ltd.) |
| dc.source.none.fl_str_mv |
reponame:RiuNet. Repositorio Institucional de la Universitat Politécnica de Valéncia instname:Universitat Politècnica de València (UPV) |
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Universitat Politècnica de València (UPV) |
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RiuNet. Repositorio Institucional de la Universitat Politécnica de Valéncia |
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RiuNet. Repositorio Institucional de la Universitat Politécnica de Valéncia |
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1869411373301104640 |
| spelling |
The role of microRNAs in understanding sex-based differences in Alzheimer s diseaseLlera&#8209Oyola, JaimeCarceller, HéctorAndreu, ZoraidaHidalgo, Marta R.Soler-Sáez, IreneGordillo-González, FernandoGómez-Cabañes, BorjaRosón, BeatrizMancuso, RobertaGuerini, Franca R.Mizokami, AkikoGarcía-García, FranciscoDE LA IGLESIA VAYÁ, MARIA DE LOS DESAMPARADOSSex-based differencesAlzheimer&aposs diseaseBiomarkersSystematic reviewMeta-analysisTranscriptomicsMicroRNAs03.- Garantizar una vida saludable y promover el bienestar para todos y todas en todas las edades[EN] Background: The incidence of Alzheimer's disease (AD)-the most frequent cause of dementia-is expected to increase as life expectancies rise across the globe. While sex-based differences in AD have previously been described, there remain uncertainties regarding any association between sex and disease-associated molecular mechanisms. Studying sex-specific expression profiles of regulatory factors such as microRNAs (miRNAs) could contribute to more accurate disease diagnosis and treatment.Methods: A systematic review identified six studies of microRNA expression in AD patients that incorporated information regarding the biological sex of samples in the Gene Expression Omnibus repository. A differential microRNA expression analysis was performed, considering disease status and patient sex. Subsequently, results were integrated within a meta-analysis methodology, with a functional enrichment of meta-analysis results establishing an association between altered miRNA expression and relevant Gene Ontology terms.Results: Meta-analyses of miRNA expression profiles in blood samples revealed the alteration of sixteen miRNAs in female and 22 miRNAs in male AD patients. We discovered nine miRNAs commonly overexpressed in both sexes, suggesting a shared miRNA dysregulation profile. Functional enrichment results based on miRNA profiles revealed sex-based differences in biological processes; most affected processes related to ubiquitination, regulation of different kinase activities, and apoptotic processes in males, but RNA splicing and translation in females. Meta-analyses of miRNA expression profiles in brain samples revealed the alteration of six miRNAs in female and four miRNAs in male AD patients. We observed a single underexpressed miRNA in female and male AD patients (hsa-miR-767-5p); however, the functional enrichment analysis for brain samples did not reveal any specifically affected biological process.Conclusions: Sex-specific meta-analyses supported the detection of differentially expressed miRNAs in female and male AD patients, highlighting the relevance of sex-based information in biomedical data. Further studies on miRNA regulation in AD patients should meet the criteria for comparability and standardization of information.This research was supported by and partially funded by the Institute of Health Carlos III (project IMPaCT-Data, exp. IMP/00019), co-funded by ERDF, "A way to make Europe", PID2021-124430OA-I00 funded by MCIN/AEI/10.13039/501100011033 and by "ERDFA way to make Europe". HC is supported by a postdoctoral "Margarita Salas" grant (MS21-074) from the Universitat de Valencia funded by the Spanish Ministry of Science and the Next Generation EU.Springer (Biomed Central Ltd.)Instituto de Salud Carlos IIIMinisterio de Educación y CienciaRepositorio Institucional de la Universitat Politècnica de València Riunet20242024-01-31journal articlehttp://purl.org/coar/resource_type/c_6501VoRhttp://purl.org/coar/version/c_970fb48d4fbd8a85info:eu-repo/semantics/articleapplication/pdfhttps://riunet.upv.es/handle/10251/221269reponame:RiuNet. Repositorio Institucional de la Universitat Politécnica de Valénciainstname:Universitat Politècnica de València (UPV)InglésengAgencia Estatal de Investigación http://dx.doi.org/10.13039/501100011033 Plan Estatal de Investigación Científica y Técnica y de Innovación 2021-2023 PID2021-124430OA-I00 ESTUDIO DE LAS DIFERENCIAS DE SEXO EN ENFERMEDADES NEURODEGENERATIVAS CON ABORDAJES INTEGRATIVOS DE DATOS OMICOS E IMAGEN BIOMEDICAInstituto de Salud Carlos III https://doi.org/10.13039/501100004587 IMP%2F00019Ministerio de Educación y Ciencia https://doi.org/10.13039/501100008743 MS21-074Ministerio de Educación y Ciencia https://doi.org/10.13039/501100008743 PID2021-124430OA-I00 PROYECTOS DE GENERACIÓN DE CONOCIMIENTO, Convocatoria 2021open accesshttp://purl.org/coar/access_right/c_abf2Reconocimiento (by)http://creativecommons.org/licenses/by/4.0/info:eu-repo/semantics/openAccessoai:riunet.upv.es:10251/2212692026-06-13T07:49:27Z |
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15.812455 |