Differentially Aquaporin 5 Expression in Submandibular Glands and Cerebral Cortex in Alzheimer’s Disease

Impaired brain clearance mechanisms may result in the accumulation of aberrant proteins that define Alzheimer's disease (AD). The water channel protein astrocytic aquaporin 4 (AQP4) is essential for brain amyloid-beta clearance, but it is known to be abnormally expressed in AD brains. The expre...

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Detalhes bibliográficos
Autores: Antequera, Desiree, Carrero, Laura, Cunha Alves, Victoria, Ferrer, Isidro (Ferrer Abizanda), Hernández Gallego, Jesús, Municio, Cristina, Carro, Eva
Tipo de documento: artigo
Estado:Versão publicada
Data de publicação:2022
País:España
Recursos:Universidad de Barcelona
Repositório:Dipòsit Digital de la UB
OAI Identifier:oai:diposit.ub.edu:2445/188689
Acesso em linha:https://hdl.handle.net/2445/188689
Access Level:Acceso aberto
Palavra-chave:Malaltia d'Alzheimer
Astròcits
Escorça cerebral
Alzheimer's disease
Astrocytes
Cerebral cortex
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spelling Differentially Aquaporin 5 Expression in Submandibular Glands and Cerebral Cortex in Alzheimer’s DiseaseAntequera, DesireeCarrero, LauraCunha Alves, VictoriaFerrer, Isidro (Ferrer Abizanda)Hernández Gallego, JesúsMunicio, CristinaCarro, EvaMalaltia d'AlzheimerAstròcitsEscorça cerebralAlzheimer's diseaseAstrocytesCerebral cortexImpaired brain clearance mechanisms may result in the accumulation of aberrant proteins that define Alzheimer's disease (AD). The water channel protein astrocytic aquaporin 4 (AQP4) is essential for brain amyloid-beta clearance, but it is known to be abnormally expressed in AD brains. The expression of AQPs is differentially regulated during diverse brain injuries, but, whereas AQP4 expression and function have been studied in AD, less is known about AQP5. AQP5 functions include not only water transport but also cell migration mediated by cytoskeleton regulation. Moreover, AQP5 has been reported to be expressed in astrocytes, which are regulated after ischemic and traumatic injury. Additionally, AQP5 is particularly abundant in the salivary glands suggesting that it may be a crucial factor in gland dysfunction associated with AD. Herein, we aim to determine whether AQP5 expression in submandibular glands and the brain was altered in AD. First, we demonstrated impaired AQP5 expression in submandibular glands in APP/PS1 mice and AD patients. Subsequently, we observed that AQP5 expression was upregulated in APP/PS1 cerebral cortex and confirmed its expression both in astrocytes and neurons. Our findings propose AQP5 as a significant role player in AD pathology, in addition to AQP4, representing a potential target for the treatment of AD.MDPI AG2022info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionapplication/pdfhttps://hdl.handle.net/2445/188689Articles publicats en revistes (Institut d'lnvestigació Biomèdica de Bellvitge (IDIBELL))reponame:Dipòsit Digital de la UBinstname:Universidad de BarcelonaInglésReproducció del document publicat a: https://doi.org/10.3390/biomedicines10071645Biomedicines, 2022, vol. 10, num. 7, p. 1645https://doi.org/10.3390/biomedicines10071645cc by (c) Antequera, Desiree et al., 2022http://creativecommons.org/licenses/by/3.0/es/info:eu-repo/semantics/openAccessoai:diposit.ub.edu:2445/1886892026-05-27T06:46:51Z
dc.title.none.fl_str_mv Differentially Aquaporin 5 Expression in Submandibular Glands and Cerebral Cortex in Alzheimer’s Disease
title Differentially Aquaporin 5 Expression in Submandibular Glands and Cerebral Cortex in Alzheimer’s Disease
spellingShingle Differentially Aquaporin 5 Expression in Submandibular Glands and Cerebral Cortex in Alzheimer’s Disease
Antequera, Desiree
Malaltia d'Alzheimer
Astròcits
Escorça cerebral
Alzheimer's disease
Astrocytes
Cerebral cortex
title_short Differentially Aquaporin 5 Expression in Submandibular Glands and Cerebral Cortex in Alzheimer’s Disease
title_full Differentially Aquaporin 5 Expression in Submandibular Glands and Cerebral Cortex in Alzheimer’s Disease
title_fullStr Differentially Aquaporin 5 Expression in Submandibular Glands and Cerebral Cortex in Alzheimer’s Disease
title_full_unstemmed Differentially Aquaporin 5 Expression in Submandibular Glands and Cerebral Cortex in Alzheimer’s Disease
title_sort Differentially Aquaporin 5 Expression in Submandibular Glands and Cerebral Cortex in Alzheimer’s Disease
dc.creator.none.fl_str_mv Antequera, Desiree
Carrero, Laura
Cunha Alves, Victoria
Ferrer, Isidro (Ferrer Abizanda)
Hernández Gallego, Jesús
Municio, Cristina
Carro, Eva
author Antequera, Desiree
author_facet Antequera, Desiree
Carrero, Laura
Cunha Alves, Victoria
Ferrer, Isidro (Ferrer Abizanda)
Hernández Gallego, Jesús
Municio, Cristina
Carro, Eva
author_role author
author2 Carrero, Laura
Cunha Alves, Victoria
Ferrer, Isidro (Ferrer Abizanda)
Hernández Gallego, Jesús
Municio, Cristina
Carro, Eva
author2_role author
author
author
author
author
author
dc.subject.none.fl_str_mv Malaltia d'Alzheimer
Astròcits
Escorça cerebral
Alzheimer's disease
Astrocytes
Cerebral cortex
topic Malaltia d'Alzheimer
Astròcits
Escorça cerebral
Alzheimer's disease
Astrocytes
Cerebral cortex
description Impaired brain clearance mechanisms may result in the accumulation of aberrant proteins that define Alzheimer's disease (AD). The water channel protein astrocytic aquaporin 4 (AQP4) is essential for brain amyloid-beta clearance, but it is known to be abnormally expressed in AD brains. The expression of AQPs is differentially regulated during diverse brain injuries, but, whereas AQP4 expression and function have been studied in AD, less is known about AQP5. AQP5 functions include not only water transport but also cell migration mediated by cytoskeleton regulation. Moreover, AQP5 has been reported to be expressed in astrocytes, which are regulated after ischemic and traumatic injury. Additionally, AQP5 is particularly abundant in the salivary glands suggesting that it may be a crucial factor in gland dysfunction associated with AD. Herein, we aim to determine whether AQP5 expression in submandibular glands and the brain was altered in AD. First, we demonstrated impaired AQP5 expression in submandibular glands in APP/PS1 mice and AD patients. Subsequently, we observed that AQP5 expression was upregulated in APP/PS1 cerebral cortex and confirmed its expression both in astrocytes and neurons. Our findings propose AQP5 as a significant role player in AD pathology, in addition to AQP4, representing a potential target for the treatment of AD.
publishDate 2022
dc.date.none.fl_str_mv 2022
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv https://hdl.handle.net/2445/188689
url https://hdl.handle.net/2445/188689
dc.language.none.fl_str_mv Inglés
language_invalid_str_mv Inglés
dc.relation.none.fl_str_mv Reproducció del document publicat a: https://doi.org/10.3390/biomedicines10071645
Biomedicines, 2022, vol. 10, num. 7, p. 1645
https://doi.org/10.3390/biomedicines10071645
dc.rights.none.fl_str_mv cc by (c) Antequera, Desiree et al., 2022
http://creativecommons.org/licenses/by/3.0/es/
info:eu-repo/semantics/openAccess
rights_invalid_str_mv cc by (c) Antequera, Desiree et al., 2022
http://creativecommons.org/licenses/by/3.0/es/
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv MDPI AG
publisher.none.fl_str_mv MDPI AG
dc.source.none.fl_str_mv Articles publicats en revistes (Institut d'lnvestigació Biomèdica de Bellvitge (IDIBELL))
reponame:Dipòsit Digital de la UB
instname:Universidad de Barcelona
instname_str Universidad de Barcelona
reponame_str Dipòsit Digital de la UB
collection Dipòsit Digital de la UB
repository.name.fl_str_mv
repository.mail.fl_str_mv
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score 15,300724

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