Attributable mortality to candidiasis in non-neutropenic critically Ill patients in the ICU and a post-mortem study

Candidiasis remains one of the most challenging infections to treat in critical care, due to its diagnostic difficulties and uncertainty regarding whether it can be directly related to the death of patients with multiorgan failure. This study aims to verify that the statistically attributable mortal...

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Autores: Ibañez, Jordi, Garcia Hernandez, Felip, Carrasco Codina, Miquel, Nolla-Salas, Miquel
Tipo de recurso: artículo
Fecha de publicación:2025
País:España
Institución:Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)
Repositorio:Recercat. Dipósit de la Recerca de Catalunya
OAI Identifier:oai:recercat.cat:20.500.14342/5683
Acceso en línea:http://hdl.handle.net/20.500.14342/5683
https://doi.org/10.3390/ jof11120871
Access Level:acceso abierto
Palabra clave:Candidiasi
Mortalitat
No neutropènic
Unitats de cures intensives
Estudi post mortem
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spelling Attributable mortality to candidiasis in non-neutropenic critically Ill patients in the ICU and a post-mortem studyIbañez, JordiGarcia Hernandez, FelipCarrasco Codina, MiquelNolla-Salas, MiquelCandidiasiMortalitatNo neutropènicUnitats de cures intensivesEstudi post mortemCandidiasis remains one of the most challenging infections to treat in critical care, due to its diagnostic difficulties and uncertainty regarding whether it can be directly related to the death of patients with multiorgan failure. This study aims to verify that the statistically attributable mortality in this infection is as consistent as the post-mortem attributable mortality. A prospective study was conducted in non-neutropenic ICU patients in whom Candida was detected. Invasive candidiasis is defined based on evidence of disseminated or multifocal candidiasis. Post-mortem study is used as the gold standard for Candida-attributable mortality, and is compared with attributable mortality determined according to clinical study and statistically attributable mortality in relation to the overall mortality of ICU patients and colonized patients. The post-mortem attributable mortality was 30.6% and 22.6% according to the clinical study, while the statistically attributable mortality was 25% in relation to overall ICU mortality and 27% in relation to Candida colonization. Thus, the results of the different calculations of attributable mortality (statistical vs. crude death rate) due to Candida are in agreement. The use of this metric may help to improve ICU outcomes for non-neutropenic critically ill patients with candidiasis.info:eu-repo/semantics/publishedVersionMDPIUniversitat Ramon Llull. Facultat de Ciències de la Salut Blanquerna2025info:eu-repo/semantics/article14 p.http://hdl.handle.net/20.500.14342/5683https://doi.org/10.3390/ jof11120871reponame:Recercat. Dipósit de la Recerca de Catalunyainstname:Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)InglésJournal of Fungi, 2025, 11(12): 871© L'autor/aAttribution 4.0 Internationalhttp://creativecommons.org/licenses/by/4.0/info:eu-repo/semantics/openAccessoai:recercat.cat:20.500.14342/56832026-05-29T05:05:01Z
dc.title.none.fl_str_mv Attributable mortality to candidiasis in non-neutropenic critically Ill patients in the ICU and a post-mortem study
title Attributable mortality to candidiasis in non-neutropenic critically Ill patients in the ICU and a post-mortem study
spellingShingle Attributable mortality to candidiasis in non-neutropenic critically Ill patients in the ICU and a post-mortem study
Ibañez, Jordi
Candidiasi
Mortalitat
No neutropènic
Unitats de cures intensives
Estudi post mortem
title_short Attributable mortality to candidiasis in non-neutropenic critically Ill patients in the ICU and a post-mortem study
title_full Attributable mortality to candidiasis in non-neutropenic critically Ill patients in the ICU and a post-mortem study
title_fullStr Attributable mortality to candidiasis in non-neutropenic critically Ill patients in the ICU and a post-mortem study
title_full_unstemmed Attributable mortality to candidiasis in non-neutropenic critically Ill patients in the ICU and a post-mortem study
title_sort Attributable mortality to candidiasis in non-neutropenic critically Ill patients in the ICU and a post-mortem study
dc.creator.none.fl_str_mv Ibañez, Jordi
Garcia Hernandez, Felip
Carrasco Codina, Miquel
Nolla-Salas, Miquel
author Ibañez, Jordi
author_facet Ibañez, Jordi
Garcia Hernandez, Felip
Carrasco Codina, Miquel
Nolla-Salas, Miquel
author_role author
author2 Garcia Hernandez, Felip
Carrasco Codina, Miquel
Nolla-Salas, Miquel
author2_role author
author
author
dc.contributor.none.fl_str_mv Universitat Ramon Llull. Facultat de Ciències de la Salut Blanquerna
dc.subject.none.fl_str_mv Candidiasi
Mortalitat
No neutropènic
Unitats de cures intensives
Estudi post mortem
topic Candidiasi
Mortalitat
No neutropènic
Unitats de cures intensives
Estudi post mortem
description Candidiasis remains one of the most challenging infections to treat in critical care, due to its diagnostic difficulties and uncertainty regarding whether it can be directly related to the death of patients with multiorgan failure. This study aims to verify that the statistically attributable mortality in this infection is as consistent as the post-mortem attributable mortality. A prospective study was conducted in non-neutropenic ICU patients in whom Candida was detected. Invasive candidiasis is defined based on evidence of disseminated or multifocal candidiasis. Post-mortem study is used as the gold standard for Candida-attributable mortality, and is compared with attributable mortality determined according to clinical study and statistically attributable mortality in relation to the overall mortality of ICU patients and colonized patients. The post-mortem attributable mortality was 30.6% and 22.6% according to the clinical study, while the statistically attributable mortality was 25% in relation to overall ICU mortality and 27% in relation to Candida colonization. Thus, the results of the different calculations of attributable mortality (statistical vs. crude death rate) due to Candida are in agreement. The use of this metric may help to improve ICU outcomes for non-neutropenic critically ill patients with candidiasis.
publishDate 2025
dc.date.none.fl_str_mv 2025
dc.type.none.fl_str_mv info:eu-repo/semantics/article
format article
dc.identifier.none.fl_str_mv http://hdl.handle.net/20.500.14342/5683
https://doi.org/10.3390/ jof11120871
url http://hdl.handle.net/20.500.14342/5683
https://doi.org/10.3390/ jof11120871
dc.language.none.fl_str_mv Inglés
language_invalid_str_mv Inglés
dc.relation.none.fl_str_mv Journal of Fungi, 2025, 11(12): 871
dc.rights.none.fl_str_mv © L'autor/a
Attribution 4.0 International
http://creativecommons.org/licenses/by/4.0/
info:eu-repo/semantics/openAccess
rights_invalid_str_mv © L'autor/a
Attribution 4.0 International
http://creativecommons.org/licenses/by/4.0/
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv 14 p.
dc.publisher.none.fl_str_mv MDPI
publisher.none.fl_str_mv MDPI
dc.source.none.fl_str_mv reponame:Recercat. Dipósit de la Recerca de Catalunya
instname:Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)
instname_str Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)
reponame_str Recercat. Dipósit de la Recerca de Catalunya
collection Recercat. Dipósit de la Recerca de Catalunya
repository.name.fl_str_mv
repository.mail.fl_str_mv
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