Principal component analysis of the effects of environmental enrichment and (-)-epigallocatechin-3-gallate on age-associated learning deficits in a mouse model of down syndrome.

Down syndrome (DS) individuals present increased risk for Alzheimer's disease (AD) neuropathology and AD-type dementia. Here, we investigated the use of green tea extracts containing (-)-epigallocatechin-3-gallate (EGCG), as co-adjuvant to enhance the effects of environmental enrichment (EE...

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Autores: Catuara Solarz, Silvina, 1986-, Espinosa-Carrasco, José, Erb, Ionas, Langohr, Klaus, Notredame, Cedric, González Ruiz, Juan Ramón, Dierssen, Mara
Tipo de recurso: artículo
Estado:Versión publicada
Fecha de publicación:2015
País:España
Institución:Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)
Repositorio:Recercat. Dipósit de la Recerca de Catalunya
OAI Identifier:oai:recercat.cat:10230/25732
Acceso en línea:http://hdl.handle.net/10230/25732
http://dx.doi.org/10.3389/fnbeh.2015.00330
Access Level:acceso abierto
Palabra clave:Down, Síndrome de
Alzheimer, Malaltia d&apos
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spelling Principal component analysis of the effects of environmental enrichment and (-)-epigallocatechin-3-gallate on age-associated learning deficits in a mouse model of down syndrome.Catuara Solarz, Silvina, 1986-Espinosa-Carrasco, JoséErb, IonasLangohr, KlausNotredame, CedricGonzález Ruiz, Juan RamónDierssen, MaraDown, Síndrome deAlzheimer, Malaltia d&aposDown syndrome (DS) individuals present increased risk for Alzheimer's disease (AD) neuropathology and AD-type dementia. Here, we investigated the use of green tea extracts containing (-)-epigallocatechin-3-gallate (EGCG), as co-adjuvant to enhance the effects of environmental enrichment (EE) in Ts65Dn mice, a segmental trisomy model of DS that partially mimics DS/AD pathology, at the age of initiation of cognitive decline. Classical repeated measures ANOVA showed that combined EE-EGCG treatment was more efficient than EE or EGCG alone to improve specific spatial learning related variables. Using principal component analysis (PCA) we found that several spatial learning parameters contributed similarly to a first PC and explained a large proportion of the variance among groups, thus representing a composite learning measure. This PC1 revealed that EGCG or EE alone had no significant effect. However, combined EE-EGCG significantly ameliorated learning alterations of middle age Ts65Dn mice. Interestingly, PCA revealed an increased variability along learning sessions with good and poor learners in Ts65Dn, and this stratification did not disappear upon treatments. Our results suggest that combining EE and EGCG represents a viable therapeutic approach for amelioration of age-related cognitive decline in DS, although its efficacy may vary across individuals.The laboratory of Mara Dierssen is supported by DIUE de la Generalitat de Catalunya (Grups consolidats SGR 2014/1125). This work was supported by Fondation Jérôme Lejeune (Paris, France), MINECO (SAF2013-49129-C2-1-R), CDTI (“Smartfoods”), and EU (Era Net Neuron PCIN-2013-060). The CRG is a Center of Excellence Severo Ochoa SEV-2012-0208. The CIBER of Rare Diseases is an initiative of the ISCIII. The laboratory of Cedric Notredame acknowledges the funding from the Spanish Ministry of Economy and Finance (MINECO), grant number BFU2011-28575. Silvina Catuara-Solarz received a FPI doctoral fellowship from Spanish Ministry of Economy and Finance (MINECO), SAF2010-16427; Jose Espinosa-Carrasco received the FI grant from Agència de Gestió d'Ajuts Universitaris i de Recerca (AGAUR) de la Generalitat de Catalunya.Frontiers201620162015info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionapplication/pdfapplication/pdfhttp://hdl.handle.net/10230/25732http://dx.doi.org/10.3389/fnbeh.2015.00330reponame:Recercat. Dipósit de la Recerca de Catalunyainstname:Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)InglésFrontiers in Behavioral Neuroscience. 2015 Dec 11;9:330info:eu-repo/grantAgreement/ES/3PN/SAF2010-16427info:eu-repo/grantAgreement/ES/1PE/SAF2013-49129-C2-1-R© 2015 Catuara-Solarz, Espinosa-Carrasco, Erb, Langohr, Notredame, Gonzalez and Dierssen. This is an open-access article distributed under the terms of http://creativecommons.org/licenses/by/4.0/. The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.http://creativecommons.org/licenses/by/4.0/info:eu-repo/semantics/openAccessoai:recercat.cat:10230/257322026-05-29T05:05:01Z
dc.title.none.fl_str_mv Principal component analysis of the effects of environmental enrichment and (-)-epigallocatechin-3-gallate on age-associated learning deficits in a mouse model of down syndrome.
title Principal component analysis of the effects of environmental enrichment and (-)-epigallocatechin-3-gallate on age-associated learning deficits in a mouse model of down syndrome.
spellingShingle Principal component analysis of the effects of environmental enrichment and (-)-epigallocatechin-3-gallate on age-associated learning deficits in a mouse model of down syndrome.
Catuara Solarz, Silvina, 1986-
Down, Síndrome de
Alzheimer, Malaltia d&apos
title_short Principal component analysis of the effects of environmental enrichment and (-)-epigallocatechin-3-gallate on age-associated learning deficits in a mouse model of down syndrome.
title_full Principal component analysis of the effects of environmental enrichment and (-)-epigallocatechin-3-gallate on age-associated learning deficits in a mouse model of down syndrome.
title_fullStr Principal component analysis of the effects of environmental enrichment and (-)-epigallocatechin-3-gallate on age-associated learning deficits in a mouse model of down syndrome.
title_full_unstemmed Principal component analysis of the effects of environmental enrichment and (-)-epigallocatechin-3-gallate on age-associated learning deficits in a mouse model of down syndrome.
title_sort Principal component analysis of the effects of environmental enrichment and (-)-epigallocatechin-3-gallate on age-associated learning deficits in a mouse model of down syndrome.
dc.creator.none.fl_str_mv Catuara Solarz, Silvina, 1986-
Espinosa-Carrasco, José
Erb, Ionas
Langohr, Klaus
Notredame, Cedric
González Ruiz, Juan Ramón
Dierssen, Mara
author Catuara Solarz, Silvina, 1986-
author_facet Catuara Solarz, Silvina, 1986-
Espinosa-Carrasco, José
Erb, Ionas
Langohr, Klaus
Notredame, Cedric
González Ruiz, Juan Ramón
Dierssen, Mara
author_role author
author2 Espinosa-Carrasco, José
Erb, Ionas
Langohr, Klaus
Notredame, Cedric
González Ruiz, Juan Ramón
Dierssen, Mara
author2_role author
author
author
author
author
author
dc.subject.none.fl_str_mv Down, Síndrome de
Alzheimer, Malaltia d&apos
topic Down, Síndrome de
Alzheimer, Malaltia d&apos
description Down syndrome (DS) individuals present increased risk for Alzheimer's disease (AD) neuropathology and AD-type dementia. Here, we investigated the use of green tea extracts containing (-)-epigallocatechin-3-gallate (EGCG), as co-adjuvant to enhance the effects of environmental enrichment (EE) in Ts65Dn mice, a segmental trisomy model of DS that partially mimics DS/AD pathology, at the age of initiation of cognitive decline. Classical repeated measures ANOVA showed that combined EE-EGCG treatment was more efficient than EE or EGCG alone to improve specific spatial learning related variables. Using principal component analysis (PCA) we found that several spatial learning parameters contributed similarly to a first PC and explained a large proportion of the variance among groups, thus representing a composite learning measure. This PC1 revealed that EGCG or EE alone had no significant effect. However, combined EE-EGCG significantly ameliorated learning alterations of middle age Ts65Dn mice. Interestingly, PCA revealed an increased variability along learning sessions with good and poor learners in Ts65Dn, and this stratification did not disappear upon treatments. Our results suggest that combining EE and EGCG represents a viable therapeutic approach for amelioration of age-related cognitive decline in DS, although its efficacy may vary across individuals.
publishDate 2015
dc.date.none.fl_str_mv 2015
2016
2016
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/10230/25732
http://dx.doi.org/10.3389/fnbeh.2015.00330
url http://hdl.handle.net/10230/25732
http://dx.doi.org/10.3389/fnbeh.2015.00330
dc.language.none.fl_str_mv Inglés
language_invalid_str_mv Inglés
dc.relation.none.fl_str_mv Frontiers in Behavioral Neuroscience. 2015 Dec 11;9:330
info:eu-repo/grantAgreement/ES/3PN/SAF2010-16427
info:eu-repo/grantAgreement/ES/1PE/SAF2013-49129-C2-1-R
dc.rights.none.fl_str_mv http://creativecommons.org/licenses/by/4.0/
info:eu-repo/semantics/openAccess
rights_invalid_str_mv http://creativecommons.org/licenses/by/4.0/
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
application/pdf
dc.publisher.none.fl_str_mv Frontiers
publisher.none.fl_str_mv Frontiers
dc.source.none.fl_str_mv reponame:Recercat. Dipósit de la Recerca de Catalunya
instname:Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)
instname_str Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)
reponame_str Recercat. Dipósit de la Recerca de Catalunya
collection Recercat. Dipósit de la Recerca de Catalunya
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