Mediterranean Diet Is a Predictor of Progression of Subclinical Atherosclerosis in a Mediterranean Population
Atherosclerotic cardiovascular disease remains a major health issue, often developing silently as subclinical atherosclerotic disease (SAD). The Mediterranean diet (MDiet) is known for its cardiovascular benefits, but the combined influence of both MDiet adherence and physical activity (PA) on SAD p...
| Authors: | , , , , , , , , , , , , , , , , , |
|---|---|
| Format: | article |
| Publication Date: | 2024 |
| Country: | España |
| Institution: | Universitat Autònoma de Barcelona |
| Repository: | Dipòsit Digital de Documents de la UAB |
| Language: | English |
| OAI Identifier: | oai:ddd.uab.cat:308598 |
| Online Access: | https://ddd.uab.cat/record/308598 https://dx.doi.org/urn:doi:10.3390/nu16213607 |
| Access Level: | Open access |
| Keyword: | Mediterranean diet Atherosclerotic plaque Lifestyle score Physical activity Subclinical atherosclerosis |
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Mediterranean Diet Is a Predictor of Progression of Subclinical Atherosclerosis in a Mediterranean Population The ILERVAS Prospective Cohort Study |
| title |
Mediterranean Diet Is a Predictor of Progression of Subclinical Atherosclerosis in a Mediterranean Population |
| spellingShingle |
Mediterranean Diet Is a Predictor of Progression of Subclinical Atherosclerosis in a Mediterranean Population Rojo López, Marina Idalia|||0000-0001-6748-3156 Mediterranean diet Atherosclerotic plaque Lifestyle score Physical activity Subclinical atherosclerosis |
| title_short |
Mediterranean Diet Is a Predictor of Progression of Subclinical Atherosclerosis in a Mediterranean Population |
| title_full |
Mediterranean Diet Is a Predictor of Progression of Subclinical Atherosclerosis in a Mediterranean Population |
| title_fullStr |
Mediterranean Diet Is a Predictor of Progression of Subclinical Atherosclerosis in a Mediterranean Population |
| title_full_unstemmed |
Mediterranean Diet Is a Predictor of Progression of Subclinical Atherosclerosis in a Mediterranean Population |
| title_sort |
Mediterranean Diet Is a Predictor of Progression of Subclinical Atherosclerosis in a Mediterranean Population |
| dc.creator.none.fl_str_mv |
Rojo López, Marina Idalia|||0000-0001-6748-3156 Bermúdez-López, Marcelino|||0000-0002-3188-4158 Castro, Eva Farràs-Sallés, Cristina|||0000-0001-5956-4116 Torres, Gerard|||0000-0002-1417-7320 Pamplona, Reinald|||0000-0003-4337-6107 Lecube, Albert|||0000-0001-9684-0183 Valdivieso, José Manuel Fernández, Elvira|||0000-0001-5236-1762 Julve i Gil, Josep|||0000-0002-6531-2246 Castelblanco, Esmeralda|||0000-0002-2061-6270 Alonso Pedrol, Núria|||0000-0001-9687-8050 Antentas Peraile, María|||0009-0005-8140-203X Barranco-Altirriba, Maria|||0000-0002-1525-210X Perera Lluna, Alexandre|||0000-0001-6427-851X Franch-Nadal, Josep|||0000-0002-5175-1555 Granado-Casas, Minerva|||0000-0003-3447-5728 Mauricio, Didac|||0000-0002-2868-0250 |
| author |
Rojo López, Marina Idalia|||0000-0001-6748-3156 |
| author_facet |
Rojo López, Marina Idalia|||0000-0001-6748-3156 Bermúdez-López, Marcelino|||0000-0002-3188-4158 Castro, Eva Farràs-Sallés, Cristina|||0000-0001-5956-4116 Torres, Gerard|||0000-0002-1417-7320 Pamplona, Reinald|||0000-0003-4337-6107 Lecube, Albert|||0000-0001-9684-0183 Valdivieso, José Manuel Fernández, Elvira|||0000-0001-5236-1762 Julve i Gil, Josep|||0000-0002-6531-2246 Castelblanco, Esmeralda|||0000-0002-2061-6270 Alonso Pedrol, Núria|||0000-0001-9687-8050 Antentas Peraile, María|||0009-0005-8140-203X Barranco-Altirriba, Maria|||0000-0002-1525-210X Perera Lluna, Alexandre|||0000-0001-6427-851X Franch-Nadal, Josep|||0000-0002-5175-1555 Granado-Casas, Minerva|||0000-0003-3447-5728 Mauricio, Didac|||0000-0002-2868-0250 |
| author_role |
author |
| author2 |
Bermúdez-López, Marcelino|||0000-0002-3188-4158 Castro, Eva Farràs-Sallés, Cristina|||0000-0001-5956-4116 Torres, Gerard|||0000-0002-1417-7320 Pamplona, Reinald|||0000-0003-4337-6107 Lecube, Albert|||0000-0001-9684-0183 Valdivieso, José Manuel Fernández, Elvira|||0000-0001-5236-1762 Julve i Gil, Josep|||0000-0002-6531-2246 Castelblanco, Esmeralda|||0000-0002-2061-6270 Alonso Pedrol, Núria|||0000-0001-9687-8050 Antentas Peraile, María|||0009-0005-8140-203X Barranco-Altirriba, Maria|||0000-0002-1525-210X Perera Lluna, Alexandre|||0000-0001-6427-851X Franch-Nadal, Josep|||0000-0002-5175-1555 Granado-Casas, Minerva|||0000-0003-3447-5728 Mauricio, Didac|||0000-0002-2868-0250 |
| author2_role |
author author author author author author author author author author author author author author author author author |
| dc.contributor.none.fl_str_mv |
Universitat Autònoma de Barcelona |
| dc.subject.none.fl_str_mv |
Mediterranean diet Atherosclerotic plaque Lifestyle score Physical activity Subclinical atherosclerosis |
| topic |
Mediterranean diet Atherosclerotic plaque Lifestyle score Physical activity Subclinical atherosclerosis |
| description |
Atherosclerotic cardiovascular disease remains a major health issue, often developing silently as subclinical atherosclerotic disease (SAD). The Mediterranean diet (MDiet) is known for its cardiovascular benefits, but the combined influence of both MDiet adherence and physical activity (PA) on SAD progression has not been previously documented. Objective: We aimed to investigate how adherence to a healthy lifestyle, defined as MDiet adherence and PA level, influences SAD progression in subjects from the ILERVAS cohort follow-up. Methods: A study on 3097 participants from the ILERVAS prospective cohort was conducted. MDiet adherence was assessed using the MEDAS score, and PA categories were established using the IPAQ, both categorized into low, moderate, and high levels. Two different lifestyle scores integrating the MDiet and PA categories were built. The presence of atherosclerotic plaques was assessed by carotid and femoral ultrasound examination. Demographic, clinical, and biochemical data were also obtained. Multivariable linear, logistic, and Poisson regression models adjusted for potential confounders were used to analyze the association between the lifestyle scores and SAD progression, as well as the MDiet and PA as separate variables and number of territories with plaque. Results: A healthier lifestyle score did not show an effect on SAD progression. However, a higher MEDAS score was associated with a 3% decrease in the number of territories with plaque (IRR 0.97, 95% CI 0.96-0.99, p < 0.001), suggesting a protective effect of the adherence to the MDiet. PA did not show a significant association (IRR 1.00, 95% CI 1.00-1.00, p = 0.269). Older age, hypertension, dyslipidemia, smoking, and lower eGFR were associated with SAD progression, while the female sex was protective (IRR 0.67, 95% CI 0.63-0.72, p < 0.001). Conclusions: The findings of this study show that higher adherence to the MDiet is associated with reduced incidence of SAD, indicating its potential role in cardiovascular prevention strategies. Although a higher lifestyle score or physical activity levels did not show any significant effect, promoting the MDiet, alongside managing traditional cardiovascular risk factors, could be an effective public health intervention to prevent atherosclerosis and reduce the burden of cardiovascular disease. |
| publishDate |
2024 |
| dc.date.none.fl_str_mv |
2 2024-01-01 2024 2024-01-01 |
| dc.type.none.fl_str_mv |
Article http://purl.org/coar/resource_type/c_6501 VoR http://purl.org/coar/version/c_970fb48d4fbd8a85 |
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info:eu-repo/semantics/article |
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article |
| dc.identifier.none.fl_str_mv |
https://ddd.uab.cat/record/308598 https://dx.doi.org/urn:doi:10.3390/nu16213607 |
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https://ddd.uab.cat/record/308598 https://dx.doi.org/urn:doi:10.3390/nu16213607 |
| dc.language.none.fl_str_mv |
Inglés eng |
| language_invalid_str_mv |
Inglés |
| language |
eng |
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Ministerio de Economía y Competitividad https://doi.org/10.13039/501100003329 CB15/00071 Instituto de Salud Carlos III https://doi.org/10.13039/501100004587 PI21/00770 Ministerio de Economía y Competitividad https://doi.org/10.13039/501100003329 RD16/0009/0011 Agencia Estatal de Investigación https://doi.org/10.13039/501100011033 PID2021-122952OB-I00 Agència de Gestió d'Ajuts Universitaris i de Recerca https://doi.org/10.13039/501100003030 2021/SGR-00990 Agència de Gestió d'Ajuts Universitaris i de Recerca https://doi.org/10.13039/501100003030 2021/SGR-01052 |
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open access http://purl.org/coar/access_right/c_abf2 https://creativecommons.org/licenses/by/4.0/ |
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info:eu-repo/semantics/openAccess |
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open access http://purl.org/coar/access_right/c_abf2 https://creativecommons.org/licenses/by/4.0/ |
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openAccess |
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application/pdf |
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reponame:Dipòsit Digital de Documents de la UAB instname:Universitat Autònoma de Barcelona |
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Universitat Autònoma de Barcelona |
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Dipòsit Digital de Documents de la UAB |
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Dipòsit Digital de Documents de la UAB |
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1869411350354067456 |
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Mediterranean Diet Is a Predictor of Progression of Subclinical Atherosclerosis in a Mediterranean PopulationThe ILERVAS Prospective Cohort StudyRojo López, Marina Idalia|||0000-0001-6748-3156Bermúdez-López, Marcelino|||0000-0002-3188-4158Castro, EvaFarràs-Sallés, Cristina|||0000-0001-5956-4116Torres, Gerard|||0000-0002-1417-7320Pamplona, Reinald|||0000-0003-4337-6107Lecube, Albert|||0000-0001-9684-0183Valdivieso, José ManuelFernández, Elvira|||0000-0001-5236-1762Julve i Gil, Josep|||0000-0002-6531-2246Castelblanco, Esmeralda|||0000-0002-2061-6270Alonso Pedrol, Núria|||0000-0001-9687-8050Antentas Peraile, María|||0009-0005-8140-203XBarranco-Altirriba, Maria|||0000-0002-1525-210XPerera Lluna, Alexandre|||0000-0001-6427-851XFranch-Nadal, Josep|||0000-0002-5175-1555Granado-Casas, Minerva|||0000-0003-3447-5728Mauricio, Didac|||0000-0002-2868-0250Mediterranean dietAtherosclerotic plaqueLifestyle scorePhysical activitySubclinical atherosclerosisAtherosclerotic cardiovascular disease remains a major health issue, often developing silently as subclinical atherosclerotic disease (SAD). The Mediterranean diet (MDiet) is known for its cardiovascular benefits, but the combined influence of both MDiet adherence and physical activity (PA) on SAD progression has not been previously documented. Objective: We aimed to investigate how adherence to a healthy lifestyle, defined as MDiet adherence and PA level, influences SAD progression in subjects from the ILERVAS cohort follow-up. Methods: A study on 3097 participants from the ILERVAS prospective cohort was conducted. MDiet adherence was assessed using the MEDAS score, and PA categories were established using the IPAQ, both categorized into low, moderate, and high levels. Two different lifestyle scores integrating the MDiet and PA categories were built. The presence of atherosclerotic plaques was assessed by carotid and femoral ultrasound examination. Demographic, clinical, and biochemical data were also obtained. Multivariable linear, logistic, and Poisson regression models adjusted for potential confounders were used to analyze the association between the lifestyle scores and SAD progression, as well as the MDiet and PA as separate variables and number of territories with plaque. Results: A healthier lifestyle score did not show an effect on SAD progression. However, a higher MEDAS score was associated with a 3% decrease in the number of territories with plaque (IRR 0.97, 95% CI 0.96-0.99, p < 0.001), suggesting a protective effect of the adherence to the MDiet. PA did not show a significant association (IRR 1.00, 95% CI 1.00-1.00, p = 0.269). Older age, hypertension, dyslipidemia, smoking, and lower eGFR were associated with SAD progression, while the female sex was protective (IRR 0.67, 95% CI 0.63-0.72, p < 0.001). Conclusions: The findings of this study show that higher adherence to the MDiet is associated with reduced incidence of SAD, indicating its potential role in cardiovascular prevention strategies. Although a higher lifestyle score or physical activity levels did not show any significant effect, promoting the MDiet, alongside managing traditional cardiovascular risk factors, could be an effective public health intervention to prevent atherosclerosis and reduce the burden of cardiovascular disease.Universitat Autònoma de Barcelona 22024-01-0120242024-01-01Articlehttp://purl.org/coar/resource_type/c_6501VoRhttp://purl.org/coar/version/c_970fb48d4fbd8a85info:eu-repo/semantics/articleapplication/pdfhttps://ddd.uab.cat/record/308598https://dx.doi.org/urn:doi:10.3390/nu16213607reponame:Dipòsit Digital de Documents de la UABinstname:Universitat Autònoma de BarcelonaInglésengMinisterio de Economía y Competitividad https://doi.org/10.13039/501100003329 CB15/00071Instituto de Salud Carlos III https://doi.org/10.13039/501100004587 PI21/00770Ministerio de Economía y Competitividad https://doi.org/10.13039/501100003329 RD16/0009/0011Agencia Estatal de Investigación https://doi.org/10.13039/501100011033 PID2021-122952OB-I00Agència de Gestió d'Ajuts Universitaris i de Recerca https://doi.org/10.13039/501100003030 2021/SGR-00990Agència de Gestió d'Ajuts Universitaris i de Recerca https://doi.org/10.13039/501100003030 2021/SGR-01052open accesshttp://purl.org/coar/access_right/c_abf2Aquest document està subjecte a una llicència d'ús Creative Commons. Es permet la reproducció total o parcial, la distribució, la comunicació pública de l'obra i la creació d'obres derivades, fins i tot amb finalitats comercials, sempre i quan es reconegui l'autoria de l'obra original.https://creativecommons.org/licenses/by/4.0/info:eu-repo/semantics/openAccessoai:ddd.uab.cat:3085982026-06-06T12:50:31Z |
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