Association between serum copper levels and risk of cardiovascular disease: A nested case-control study in the PREDIMED trial

Muñoz Bravo, Carlos; Olmedo, Pablo; Gil, Fernando; Ruiz Canela, Miguel; Martínez-González, Miguel Ángel, 1957-; Martínez, María Ángeles; Babio, Nancy; Fitó Colomer, Montserrat; Del Val García, Jose Luís; Corella Piquer, Dolores; Sorlí, José V.; Ros Rahola, Emilio; Fiol Sala, Miguel; Estruch Riba, Ramon; Santos Lozano, José Manuel; Arós, Fernando; Serra Majem, Lluís; Pintó Sala, Xavier; Gómez Gracia, Enrique; Gutierrez Bedmar, Mario

Association between serum copper levels and risk of cardiovascular disease: A nested case-control study in the PREDIMED trial

Background and aim: Certain trace elements have been associated with increased cardiovascular risk. The aim of this study was to evaluate the association between serum copper (S-Cu) levels and the risk of a first event of cardiovascular disease (CVD) in a population of older adults with high cardiov...

Descripción completa

Detalles Bibliográficos
Autores:	Muñoz Bravo, Carlos, Olmedo, Pablo, Gil, Fernando, Ruiz Canela, Miguel, Martínez-González, Miguel Ángel, 1957-, Martínez, María Ángeles, Babio, Nancy, Fitó Colomer, Montserrat, Del Val García, Jose Luís, Corella Piquer, Dolores, Sorlí, José V., Ros Rahola, Emilio, Fiol Sala, Miguel, Estruch Riba, Ramon, Santos Lozano, José Manuel, Arós, Fernando, Serra Majem, Lluís, Pintó Sala, Xavier, Gómez Gracia, Enrique, Gutierrez Bedmar, Mario
Tipo de recurso:	artículo
Estado:	Versión publicada
Fecha de publicación:	2023
País:	España
Institución:	Universidad de Barcelona
Repositorio:	Dipòsit Digital de la UB
OAI Identifier:	oai:diposit.ub.edu:2445/207360
Acceso en línea:	https://hdl.handle.net/2445/207360
Access Level:	acceso abierto
Palabra clave:	Malalties cardiovasculars Sèrum Coure en l'organisme Cardiovascular diseases Serum Copper in the body

id	ES_79666e89d71dad6ee7d265a2d6fbcf46
oai_identifier_str	oai:diposit.ub.edu:2445/207360
network_acronym_str	ES
network_name_str	España
repository_id_str
spelling	Association between serum copper levels and risk of cardiovascular disease: A nested case-control study in the PREDIMED trialMuñoz Bravo, CarlosOlmedo, PabloGil, FernandoRuiz Canela, MiguelMartínez-González, Miguel Ángel, 1957-Martínez, María ÁngelesBabio, NancyFitó Colomer, MontserratDel Val García, Jose LuísCorella Piquer, DoloresSorlí, José V.Ros Rahola, EmilioFiol Sala, MiguelEstruch Riba, RamonSantos Lozano, José ManuelArós, FernandoSerra Majem, LluísPintó Sala, XavierGómez Gracia, EnriqueGutierrez Bedmar, MarioMalalties cardiovascularsSèrumCoure en l'organismeCardiovascular diseasesSerumCopper in the bodyBackground and aim: Certain trace elements have been associated with increased cardiovascular risk. The aim of this study was to evaluate the association between serum copper (S-Cu) levels and the risk of a first event of cardiovascular disease (CVD) in a population of older adults with high cardiovascular risk. Methods and results: We conducted a case-control study nested within the PREDIMED trial. During a median follow-up of 4.8 years, a total of 207 incident cases diagnosed with CVD were matched for sex, age, and intervention group with 436 controls. Personal interviews, reviews of medical records, and validated questionnaires were used to assess known CVD risk factors. Biological serum samples were collected annually. Inductively coupled plasma mass spectrometry analysis was used to determine S-Cu levels. Adjusted odds ratios were calculated using multivariate conditional logistic regression models. All participants had S-Cu levels within the reference values, 750 μg/L to 1450 μg/L. Among men, but not among women, the mean S-Cu concentration was higher in cases 1014.1 μg/L than in controls 959.3 μg/L; (p = 0.004). In men, the multivariable-adjusted odds ratio for CVD was 2.36 (95% CI 1.07-5.20 for the comparison of the highest vs. the lowest quartile; p for trend = 0.02), in women, it was 0.43 (95% CI 0.11-1.70; p for trend = 0.165). Conclusion: In older Spanish men with high cardiovascular risk, a significant association was observed between high S-Cu levels, but still within the reference values, and an increased risk of a first event of CVD. Our findings suggest a sex difference in CVD risk and S-Cu levels. To confirm this relationship and to analyze the differences observed between men and women, further studies are needed.Elsevier B.V.2023info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionapplication/pdfhttps://hdl.handle.net/2445/207360Articles publicats en revistes (Medicina)reponame:Dipòsit Digital de la UBinstname:Universidad de BarcelonaInglésReproducció del document publicat a: https://doi.org/10.1016/j.numecd.2023.07.008Nutrition Metabolism and Cardiovascular Diseases, 2023, vol. 33, num.11, p. 2199-2208https://doi.org/10.1016/j.numecd.2023.07.008cc-by-nc-nd (c) Muñoz-Bravo et al., 2023http://creativecommons.org/licenses/by-nc-nd/4.0/info:eu-repo/semantics/openAccessoai:diposit.ub.edu:2445/2073602026-05-27T06:46:51Z
dc.title.none.fl_str_mv	Association between serum copper levels and risk of cardiovascular disease: A nested case-control study in the PREDIMED trial
title	Association between serum copper levels and risk of cardiovascular disease: A nested case-control study in the PREDIMED trial
spellingShingle	Association between serum copper levels and risk of cardiovascular disease: A nested case-control study in the PREDIMED trial Muñoz Bravo, Carlos Malalties cardiovasculars Sèrum Coure en l'organisme Cardiovascular diseases Serum Copper in the body
title_short	Association between serum copper levels and risk of cardiovascular disease: A nested case-control study in the PREDIMED trial
title_full	Association between serum copper levels and risk of cardiovascular disease: A nested case-control study in the PREDIMED trial
title_fullStr	Association between serum copper levels and risk of cardiovascular disease: A nested case-control study in the PREDIMED trial
title_full_unstemmed	Association between serum copper levels and risk of cardiovascular disease: A nested case-control study in the PREDIMED trial
title_sort	Association between serum copper levels and risk of cardiovascular disease: A nested case-control study in the PREDIMED trial
dc.creator.none.fl_str_mv	Muñoz Bravo, Carlos Olmedo, Pablo Gil, Fernando Ruiz Canela, Miguel Martínez-González, Miguel Ángel, 1957- Martínez, María Ángeles Babio, Nancy Fitó Colomer, Montserrat Del Val García, Jose Luís Corella Piquer, Dolores Sorlí, José V. Ros Rahola, Emilio Fiol Sala, Miguel Estruch Riba, Ramon Santos Lozano, José Manuel Arós, Fernando Serra Majem, Lluís Pintó Sala, Xavier Gómez Gracia, Enrique Gutierrez Bedmar, Mario
author	Muñoz Bravo, Carlos
author_facet	Muñoz Bravo, Carlos Olmedo, Pablo Gil, Fernando Ruiz Canela, Miguel Martínez-González, Miguel Ángel, 1957- Martínez, María Ángeles Babio, Nancy Fitó Colomer, Montserrat Del Val García, Jose Luís Corella Piquer, Dolores Sorlí, José V. Ros Rahola, Emilio Fiol Sala, Miguel Estruch Riba, Ramon Santos Lozano, José Manuel Arós, Fernando Serra Majem, Lluís Pintó Sala, Xavier Gómez Gracia, Enrique Gutierrez Bedmar, Mario
author_role	author
author2	Olmedo, Pablo Gil, Fernando Ruiz Canela, Miguel Martínez-González, Miguel Ángel, 1957- Martínez, María Ángeles Babio, Nancy Fitó Colomer, Montserrat Del Val García, Jose Luís Corella Piquer, Dolores Sorlí, José V. Ros Rahola, Emilio Fiol Sala, Miguel Estruch Riba, Ramon Santos Lozano, José Manuel Arós, Fernando Serra Majem, Lluís Pintó Sala, Xavier Gómez Gracia, Enrique Gutierrez Bedmar, Mario
author2_role	author author author author author author author author author author author author author author author author author author author
dc.subject.none.fl_str_mv	Malalties cardiovasculars Sèrum Coure en l'organisme Cardiovascular diseases Serum Copper in the body
topic	Malalties cardiovasculars Sèrum Coure en l'organisme Cardiovascular diseases Serum Copper in the body
description	Background and aim: Certain trace elements have been associated with increased cardiovascular risk. The aim of this study was to evaluate the association between serum copper (S-Cu) levels and the risk of a first event of cardiovascular disease (CVD) in a population of older adults with high cardiovascular risk. Methods and results: We conducted a case-control study nested within the PREDIMED trial. During a median follow-up of 4.8 years, a total of 207 incident cases diagnosed with CVD were matched for sex, age, and intervention group with 436 controls. Personal interviews, reviews of medical records, and validated questionnaires were used to assess known CVD risk factors. Biological serum samples were collected annually. Inductively coupled plasma mass spectrometry analysis was used to determine S-Cu levels. Adjusted odds ratios were calculated using multivariate conditional logistic regression models. All participants had S-Cu levels within the reference values, 750 μg/L to 1450 μg/L. Among men, but not among women, the mean S-Cu concentration was higher in cases 1014.1 μg/L than in controls 959.3 μg/L; (p = 0.004). In men, the multivariable-adjusted odds ratio for CVD was 2.36 (95% CI 1.07-5.20 for the comparison of the highest vs. the lowest quartile; p for trend = 0.02), in women, it was 0.43 (95% CI 0.11-1.70; p for trend = 0.165). Conclusion: In older Spanish men with high cardiovascular risk, a significant association was observed between high S-Cu levels, but still within the reference values, and an increased risk of a first event of CVD. Our findings suggest a sex difference in CVD risk and S-Cu levels. To confirm this relationship and to analyze the differences observed between men and women, further studies are needed.
publishDate	2023
dc.date.none.fl_str_mv	2023
dc.type.none.fl_str_mv	info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion
format	article
status_str	publishedVersion
dc.identifier.none.fl_str_mv	https://hdl.handle.net/2445/207360
url	https://hdl.handle.net/2445/207360
dc.language.none.fl_str_mv	Inglés
language_invalid_str_mv	Inglés
dc.relation.none.fl_str_mv	Reproducció del document publicat a: https://doi.org/10.1016/j.numecd.2023.07.008 Nutrition Metabolism and Cardiovascular Diseases, 2023, vol. 33, num.11, p. 2199-2208 https://doi.org/10.1016/j.numecd.2023.07.008
dc.rights.none.fl_str_mv	cc-by-nc-nd (c) Muñoz-Bravo et al., 2023 http://creativecommons.org/licenses/by-nc-nd/4.0/ info:eu-repo/semantics/openAccess
rights_invalid_str_mv	cc-by-nc-nd (c) Muñoz-Bravo et al., 2023 http://creativecommons.org/licenses/by-nc-nd/4.0/
eu_rights_str_mv	openAccess
dc.format.none.fl_str_mv	application/pdf
dc.publisher.none.fl_str_mv	Elsevier B.V.
publisher.none.fl_str_mv	Elsevier B.V.
dc.source.none.fl_str_mv	Articles publicats en revistes (Medicina) reponame:Dipòsit Digital de la UB instname:Universidad de Barcelona
instname_str	Universidad de Barcelona
reponame_str	Dipòsit Digital de la UB
collection	Dipòsit Digital de la UB
repository.name.fl_str_mv
repository.mail.fl_str_mv
_version_	1869411346018205696
score	15,301629

Association between serum copper levels and risk of cardiovascular disease: A nested case-control study in the PREDIMED trial

Similares en LA Referencia