Study of endothelial dysfunction in chronic thromboembolic pulmonary hypertension and in COVID-19. Biomarkers and new targeted therapeutic strategies
The endothelium, the lining of our blood vessels, plays a crucial role in controlling functions such as blood flow, clotting and inflammation. When it does not function properly, called endothelial dysfunction, it can lead to serious cardiovascular problems. This research focuses on two conditions i...
| Autor: | |
|---|---|
| Formato: | tesis doctoral |
| Estado: | Versión publicada |
| Fecha de publicación: | 2024 |
| País: | España |
| Recursos: | CBUC, CESCA |
| Repositorio: | TDR. Tesis Doctorales en Red |
| OAI Identifier: | oai:www.tdx.cat:10803/692399 |
| Acesso em linha: | http://hdl.handle.net/10803/692399 |
| Access Level: | acceso abierto |
| Palavra-chave: | Endoteli Endotelio Endothelium Cèl·lules endotelials Células endoteliales Endothelial cells Disfunció endotelial Disfunción endotelial Endothelial dysfunction COVID-19 Hipertensió pulmonar tromboembòlica crònica Hipertensión pulmonar tromboembólica crónica Chronic thromboembolic pulmonary hypertension Seqüeles vasculars Secuelas vasculares Vascular sequelae Biomarcadors Biomarcadores Biomarkers Endothelium-protective drugs 616.1 |
| Resumo: | The endothelium, the lining of our blood vessels, plays a crucial role in controlling functions such as blood flow, clotting and inflammation. When it does not function properly, called endothelial dysfunction, it can lead to serious cardiovascular problems. This research focuses on two conditions in which endothelial dysfunction is critical: the effects of COVID-19 on our blood vessels and a lung condition called chronic thromboembolic pulmonary hypertension (CTEPH). COVID-19 can affect our blood vessels, which could lead to long-term problems that we do not yet fully understand. This study proposes that people who had COVID-19 may be more likely to have heart and lung problems later in life due to changes in their blood vessels. This part of the thesis specifically studies special cells in our blood vessels called endothelial progenitor cells, crucial for vessel repair, which could serve as biomarkers to assess cardiovascular risk and the long-term effects of COVID-19. CTEPH, a severe form of pulmonary hypertension, is defined by the formation of blood clots in the pulmonary arteries. This research suggests that endothelial dysfunction plays an important role in the progression of CTEPH. The use of drugs to protect the endothelium could be a new method of treating CTEPH. Overall, this research tries to understand how problems with the endothelium of our blood vessels cause these diseases. In addition, this research is trying to find new treatments or ways to predict who is at risk. This could improve the lives of patients and benefit society as a whole |
|---|