Adding two antimicrobial glasses to an endodontic sealer to prevent bacterial root canal reinfection: an in vivo pilot study in dogs

This article belongs to the Special Issue Antimicrobial Material in Dentistry.

Detalles Bibliográficos
Autores: Zubizarreta-Macho, Álvaro, Rico-Romano, Cristina, Fernandez-Aceñero, M. Jesús, Mena-Álvarez, Jesús, Cabal, Belén, Díaz, Luis A., Torrecillas, Ramón, Moya, J. S., López-Píriz, Roberto
Tipo de recurso: artículo
Estado:Versión publicada
Fecha de publicación:2021
País:España
Institución:Consejo Superior de Investigaciones Científicas (CSIC)
Repositorio:DIGITAL.CSIC. Repositorio Institucional del CSIC
OAI Identifier:oai:digital.csic.es:10261/259028
Acceso en línea:http://hdl.handle.net/10261/259028
Access Level:acceso abierto
Palabra clave:Endodontics
Apical periodontitis
Root canal sealer
Bactericidal effect
Bioactive glass
Enterococcus faecalis
Bactericidal
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spelling Adding two antimicrobial glasses to an endodontic sealer to prevent bacterial root canal reinfection: an in vivo pilot study in dogsZubizarreta-Macho, ÁlvaroRico-Romano, CristinaFernandez-Aceñero, M. JesúsMena-Álvarez, JesúsCabal, BelénDíaz, Luis A.Torrecillas, RamónMoya, J. S.López-Píriz, RobertoEndodonticsApical periodontitisRoot canal sealerBactericidal effectBioactive glassEnterococcus faecalisBactericidalThis article belongs to the Special Issue Antimicrobial Material in Dentistry.Current endodontic procedures continue to be unsuccessful for completely removing pathogens present inside the root canal system, which can lead to recurrent infections. In this study, we aimed to assess the antimicrobial capacity and tissue response of two inorganic bactericidal additives incorporated into a paste root canal sealer on contaminated root dentin in vivo. An experimental study was performed in 30 teeth of five Beagle dogs. After inducing microbiological contamination, root canal systems were treated by randomly incorporating one of two antimicrobial additives into a commercial epoxy-amine resin sealer (AH Plus), i.e., G3T glass-ceramic (n = 10) and ZnO-enriched glass (n = 10); 10 samples were randomized as a control group. After having sacrificed the animals, microbiological, radiological, and histological analyses were performed, which were complemented with an in vitro bactericidal test and characterization by field emission scanning electron microscopy. The tested groups demonstrated a non-significant microbiological reduction in the postmortem periapical index values between the control group and the bactericidal glass-ceramic group (p = 0.885), and between the control group and the ZnO-enriched glass group (p = 0.169). The histological results showed low values of inflammatory infiltrate, and a healing pattern characterized by fibrosis in 44.4% of the G3T glass-ceramic and 60.0% of ZnO-enriched glass. Bactericidal glassy additives incorporated in this root canal sealer are safe and effective in bacterial reduction.Peer reviewedMultidisciplinary Digital Publishing InstituteConsejo Superior de Investigaciones Científicas [https://ror.org/02gfc7t72]202220222021info:eu-repo/semantics/articlehttp://purl.org/coar/resource_type/c_6501Publisher's versioninfo:eu-repo/semantics/publishedVersionhttp://hdl.handle.net/10261/259028reponame:DIGITAL.CSIC. Repositorio Institucional del CSICinstname:Consejo Superior de Investigaciones Científicas (CSIC)Ingléshttps://doi.org/10.3390/antibiotics10101183Síinfo:eu-repo/semantics/openAccessoai:digital.csic.es:10261/2590282026-05-22T06:33:51Z
dc.title.none.fl_str_mv Adding two antimicrobial glasses to an endodontic sealer to prevent bacterial root canal reinfection: an in vivo pilot study in dogs
title Adding two antimicrobial glasses to an endodontic sealer to prevent bacterial root canal reinfection: an in vivo pilot study in dogs
spellingShingle Adding two antimicrobial glasses to an endodontic sealer to prevent bacterial root canal reinfection: an in vivo pilot study in dogs
Zubizarreta-Macho, Álvaro
Endodontics
Apical periodontitis
Root canal sealer
Bactericidal effect
Bioactive glass
Enterococcus faecalis
Bactericidal
title_short Adding two antimicrobial glasses to an endodontic sealer to prevent bacterial root canal reinfection: an in vivo pilot study in dogs
title_full Adding two antimicrobial glasses to an endodontic sealer to prevent bacterial root canal reinfection: an in vivo pilot study in dogs
title_fullStr Adding two antimicrobial glasses to an endodontic sealer to prevent bacterial root canal reinfection: an in vivo pilot study in dogs
title_full_unstemmed Adding two antimicrobial glasses to an endodontic sealer to prevent bacterial root canal reinfection: an in vivo pilot study in dogs
title_sort Adding two antimicrobial glasses to an endodontic sealer to prevent bacterial root canal reinfection: an in vivo pilot study in dogs
dc.creator.none.fl_str_mv Zubizarreta-Macho, Álvaro
Rico-Romano, Cristina
Fernandez-Aceñero, M. Jesús
Mena-Álvarez, Jesús
Cabal, Belén
Díaz, Luis A.
Torrecillas, Ramón
Moya, J. S.
López-Píriz, Roberto
author Zubizarreta-Macho, Álvaro
author_facet Zubizarreta-Macho, Álvaro
Rico-Romano, Cristina
Fernandez-Aceñero, M. Jesús
Mena-Álvarez, Jesús
Cabal, Belén
Díaz, Luis A.
Torrecillas, Ramón
Moya, J. S.
López-Píriz, Roberto
author_role author
author2 Rico-Romano, Cristina
Fernandez-Aceñero, M. Jesús
Mena-Álvarez, Jesús
Cabal, Belén
Díaz, Luis A.
Torrecillas, Ramón
Moya, J. S.
López-Píriz, Roberto
author2_role author
author
author
author
author
author
author
author
dc.contributor.none.fl_str_mv Consejo Superior de Investigaciones Científicas [https://ror.org/02gfc7t72]
dc.subject.none.fl_str_mv Endodontics
Apical periodontitis
Root canal sealer
Bactericidal effect
Bioactive glass
Enterococcus faecalis
Bactericidal
topic Endodontics
Apical periodontitis
Root canal sealer
Bactericidal effect
Bioactive glass
Enterococcus faecalis
Bactericidal
description This article belongs to the Special Issue Antimicrobial Material in Dentistry.
publishDate 2021
dc.date.none.fl_str_mv 2021
2022
2022
dc.type.none.fl_str_mv info:eu-repo/semantics/article
http://purl.org/coar/resource_type/c_6501
Publisher's version
info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/10261/259028
url http://hdl.handle.net/10261/259028
dc.language.none.fl_str_mv Inglés
language_invalid_str_mv Inglés
dc.relation.none.fl_str_mv https://doi.org/10.3390/antibiotics10101183
Sí
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.publisher.none.fl_str_mv Multidisciplinary Digital Publishing Institute
publisher.none.fl_str_mv Multidisciplinary Digital Publishing Institute
dc.source.none.fl_str_mv reponame:DIGITAL.CSIC. Repositorio Institucional del CSIC
instname:Consejo Superior de Investigaciones Científicas (CSIC)
instname_str Consejo Superior de Investigaciones Científicas (CSIC)
reponame_str DIGITAL.CSIC. Repositorio Institucional del CSIC
collection DIGITAL.CSIC. Repositorio Institucional del CSIC
repository.name.fl_str_mv
repository.mail.fl_str_mv
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score 15.811543

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