Role of Actin Cytoskeleton Reorganization in Polarized Secretory Traffic at the Immunologiocal Synapse

© 2021 Calvo and Izquierdo.

Detalles Bibliográficos
Autores: Izquierdo, Manuel, Calvo, Victor
Tipo de recurso: otro
Fecha de publicación:2021
País:España
Institución:Consejo Superior de Investigaciones Científicas (CSIC)
Repositorio:DIGITAL.CSIC. Repositorio Institucional del CSIC
OAI Identifier:oai:digital.csic.es:10261/266142
Acceso en línea:http://hdl.handle.net/10261/266142
Access Level:acceso abierto
Palabra clave:T lymphocytes
B lymphocytes
Imune synapse
Actin cytoskeleton
Protein kinase C δ
Centrosome
Multivesicular bodies
FMNL1
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spelling Role of Actin Cytoskeleton Reorganization in Polarized Secretory Traffic at the Immunologiocal SynapseIzquierdo, ManuelCalvo, VictorT lymphocytesB lymphocytesImune synapseActin cytoskeletonProtein kinase C δCentrosomeMultivesicular bodiesFMNL1© 2021 Calvo and Izquierdo.T cell receptor (TCR) and B cell receptor (BCR) stimulation by antigen presented on an antigen-presenting cell (APC) induces the formation of the immune synapse (IS), the convergence of secretory vesicles from T and B lymphocytes toward the centrosome, and the polarization of the centrosome to the immune synapse. Immune synapse formation is associated with an initial increase in cortical F-actin at the synapse, followed by a decrease in F-actin density at the central region of the immune synapse, which contains the secretory domain. These reversible, actin cytoskeleton reorganization processes occur during lytic granule degranulation in cytotoxic T lymphocytes (CTL) and cytokine-containing vesicle secretion in T-helper (Th) lymphocytes. Recent evidences obtained in T and B lymphocytes forming synapses show that F-actin reorganization also occurs at the centrosomal area. F-actin reduction at the centrosomal area appears to be involved in centrosome polarization. In this review we deal with the biological significance of both cortical and centrosomal area F-actin reorganization and some of the derived biological consequences.This research was funded by grants from the Spanish Ministerio de Economía y Competitividad (MINECO), Plan Nacional de Investigación Científica (SAF2016-77561-R and PID2020- 114148RB-I00) to MI, which was in part granted with FEDER funding (EC), corresponding to the Programa Estatal de Investigación, Desarrollo e Innovación Orientada a los Retos de la Sociedad.Frontiers MediaMinisterio de Economía y Competitividad (España)Ministerio de Ciencia, Innovación y Universidades (España)Agencia Estatal de Investigación (España)European CommissionConsejo Superior de Investigaciones Científicas [https://ror.org/02gfc7t72]2022202220212022info:eu-repo/semantics/otherhttp://purl.org/coar/resource_type/c_3248info:eu-repo/semantics/bookParthttp://hdl.handle.net/10261/266142reponame:DIGITAL.CSIC. Repositorio Institucional del CSICinstname:Consejo Superior de Investigaciones Científicas (CSIC)Inglés#PLACEHOLDER_PARENT_METADATA_VALUE##PLACEHOLDER_PARENT_METADATA_VALUE#info:eu-repo/grantAgreement///info:eu-repo/grantAgreement/AEI/Plan Estatal de Investigación Científica y Técnica y de Innovación 2017-2020/PID2020-114148RB-I00http://dx.doi.org/10.3389/978-2-88971-898-6Síinfo:eu-repo/semantics/openAccessoai:digital.csic.es:10261/2661422026-05-22T06:33:51Z
dc.title.none.fl_str_mv Role of Actin Cytoskeleton Reorganization in Polarized Secretory Traffic at the Immunologiocal Synapse
title Role of Actin Cytoskeleton Reorganization in Polarized Secretory Traffic at the Immunologiocal Synapse
spellingShingle Role of Actin Cytoskeleton Reorganization in Polarized Secretory Traffic at the Immunologiocal Synapse
Izquierdo, Manuel
T lymphocytes
B lymphocytes
Imune synapse
Actin cytoskeleton
Protein kinase C δ
Centrosome
Multivesicular bodies
FMNL1
title_short Role of Actin Cytoskeleton Reorganization in Polarized Secretory Traffic at the Immunologiocal Synapse
title_full Role of Actin Cytoskeleton Reorganization in Polarized Secretory Traffic at the Immunologiocal Synapse
title_fullStr Role of Actin Cytoskeleton Reorganization in Polarized Secretory Traffic at the Immunologiocal Synapse
title_full_unstemmed Role of Actin Cytoskeleton Reorganization in Polarized Secretory Traffic at the Immunologiocal Synapse
title_sort Role of Actin Cytoskeleton Reorganization in Polarized Secretory Traffic at the Immunologiocal Synapse
dc.creator.none.fl_str_mv Izquierdo, Manuel
Calvo, Victor
author Izquierdo, Manuel
author_facet Izquierdo, Manuel
Calvo, Victor
author_role author
author2 Calvo, Victor
author2_role author
dc.contributor.none.fl_str_mv Ministerio de Economía y Competitividad (España)
Ministerio de Ciencia, Innovación y Universidades (España)
Agencia Estatal de Investigación (España)
European Commission
Consejo Superior de Investigaciones Científicas [https://ror.org/02gfc7t72]
dc.subject.none.fl_str_mv T lymphocytes
B lymphocytes
Imune synapse
Actin cytoskeleton
Protein kinase C δ
Centrosome
Multivesicular bodies
FMNL1
topic T lymphocytes
B lymphocytes
Imune synapse
Actin cytoskeleton
Protein kinase C δ
Centrosome
Multivesicular bodies
FMNL1
description © 2021 Calvo and Izquierdo.
publishDate 2021
dc.date.none.fl_str_mv 2021
2022
2022
2022
dc.type.none.fl_str_mv info:eu-repo/semantics/other
http://purl.org/coar/resource_type/c_3248
dc.type.openaire.fl_str_mv info:eu-repo/semantics/bookPart
format other
dc.identifier.none.fl_str_mv http://hdl.handle.net/10261/266142
url http://hdl.handle.net/10261/266142
dc.language.none.fl_str_mv Inglés
language_invalid_str_mv Inglés
dc.relation.none.fl_str_mv #PLACEHOLDER_PARENT_METADATA_VALUE#
#PLACEHOLDER_PARENT_METADATA_VALUE#
info:eu-repo/grantAgreement///
info:eu-repo/grantAgreement/AEI/Plan Estatal de Investigación Científica y Técnica y de Innovación 2017-2020/PID2020-114148RB-I00
http://dx.doi.org/10.3389/978-2-88971-898-6
Sí
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.publisher.none.fl_str_mv Frontiers Media
publisher.none.fl_str_mv Frontiers Media
dc.source.none.fl_str_mv reponame:DIGITAL.CSIC. Repositorio Institucional del CSIC
instname:Consejo Superior de Investigaciones Científicas (CSIC)
instname_str Consejo Superior de Investigaciones Científicas (CSIC)
reponame_str DIGITAL.CSIC. Repositorio Institucional del CSIC
collection DIGITAL.CSIC. Repositorio Institucional del CSIC
repository.name.fl_str_mv
repository.mail.fl_str_mv
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score 15,812429

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