Cording mycobacterium tuberculosis bacilli have a key role in the progression towards active tuberculosis, which is stopped by previous immune response

Cording was the first virulence factor identified in Mycobacterium tuberculosis (Mtb). We aimed to ascertain its role in the induction of active tuberculosis (TB) in the mouse strain C3HeB/FeJ by testing the immunopathogenic capacity of the H37Rv strain. We have obtained two batches of the same stra...

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Detalhes bibliográficos
Autores: Arias, Lilibeth, Cardona, Paula, Català Sabaté, Martí|||0000-0003-3308-9905, Prats Soler, Clara|||0000-0002-1398-7559, Vilaplana, Cristina, Cardona Iglesias, Pere Joan|||0000-0001-5623-7873, Julian Gómez, Esther, Campo Pérez, Víctor
Tipo de documento: artigo
Data de publicação:2020
País:España
Recursos:Universitat Politècnica de Catalunya (UPC)
Repositório:UPCommons. Portal del coneixement obert de la UPC
Idioma:inglês
OAI Identifier:oai:upcommons.upc.edu:2117/334710
Acesso em linha:https://hdl.handle.net/2117/334710
https://dx.doi.org/10.3390/microorganisms8020228
Access Level:Acceso aberto
Palavra-chave:Mycobacterium tuberculosis
Cording
C3HeB/FeJ mice
Neutrophils
BCG
CXCL-1
Neutrophilic extracellular traps
Tuberculosi -- Epidemiologia
Àrees temàtiques de la UPC::Matemàtiques i estadística::Anàlisi numèrica::Modelització matemàtica
Descrição
Resumo:Cording was the first virulence factor identified in Mycobacterium tuberculosis (Mtb). We aimed to ascertain its role in the induction of active tuberculosis (TB) in the mouse strain C3HeB/FeJ by testing the immunopathogenic capacity of the H37Rv strain. We have obtained two batches of the same strain by stopping their growth in Proskauer Beck liquid medium once the mid-log phase was reached, in the noncording Mtb (NCMtb) batch, and two days later in the cording Mtb (CMtb) batch, when cording could be detected by microscopic analysis.

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