Definite and indeterminate nonalcoholic steatohepatitis share similar clinical features and prognosis: A longitudinal study of 1893 biopsy-proven nonalcoholic fatty liver disease subjects

[Background and Aim] Histological score systems may not fully capture the essential nonalcoholic steatohepatitis (NASH) features, which is one of the leading causes of screening failure in clinical trials. We assessed the NASH distribution and its components across the fibrosis stages and their impa...

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Detalhes bibliográficos
Autores: Ampuero, Javier, Aller, Rocío, Gallego-Durán, Rocío, Crespo, Javier, Abad, Javier, González-Rodríguez, Águeda, Gómez-Camarero, Judith, Caballería, Joan, Lo lacono, Oreste, Ibáñez, Luis, García-Samaniego, Javier, Martín-Mateos, Rosa, Francés, Rubén, Fernández-Rodríguez, Conrado M., Diago, Moisés, Soriano, Germán, Andrade, Raúl J., Latorre, Raquel, Jorquera, Francisco, Morillas, Rosa María, Escudero, Desamparados, Estévez, Pamela, Hernández-Guerra, Manuel, Augustin, Salvador, Pareja, María Jesús, Banales, Jesús M., Aspichueta, Patricia, Benlloch, Salvador, Rosales, José Miguel, Salmerón, Javier, Turnes, Juan, Romero-Gómez, Manuel
Formato: artículo
Estado:Versión publicada
Fecha de publicación:2021
País:España
Recursos:Consejo Superior de Investigaciones Científicas (CSIC)
Repositorio:DIGITAL.CSIC. Repositorio Institucional del CSIC
OAI Identifier:oai:digital.csic.es:10261/265210
Acesso em linha:http://hdl.handle.net/10261/265210
Access Level:acceso abierto
Palavra-chave:Ballooning
Fatty liver disease
Inflammation
Metabolic-associated fatty liver disease
Natural coursesteatohepatitis
Steatosis
Descrição
Resumo:[Background and Aim] Histological score systems may not fully capture the essential nonalcoholic steatohepatitis (NASH) features, which is one of the leading causes of screening failure in clinical trials. We assessed the NASH distribution and its components across the fibrosis stages and their impact on the prognosis and their relationship with the concept of metabolic-associated fatty liver disease (MAFLD).

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