Inadequate control of thyroid hormones sensitizes to hepatocarcinogenesis and unhealthy aging

34 Páginas.-- 7 Figuras.-- 6 Figuras suplementarias.-- 4 Tablas suplementarias

Detalhes bibliográficos
Autores: López-Noriega, Livia, Capilla-González, Vivian, Cobo-Vuilleumier, Nadia, Martín-Vázquez, Eugenia, Lorenzo, Petra Isabel, Martínez-Force, Enrique, Soriano-Navarro, Mario, García-Fernández, María, Romero-Zerbo, Silvana Y., Bermúdez-Silva, Francisco Javier, Díaz-Contreras, Irene, Sánchez-Cuesta, Ana, Santos-Ocaña, Carlos, Hmadcha, Abdelkrim, Soria Escoms, Bernat, Martín, Franz, Gauthier, Benoit R., Martín-Montalvo, Alejandro
Formato: artículo
Estado:Versión publicada
Fecha de publicación:2019
País:España
Recursos:Consejo Superior de Investigaciones Científicas (CSIC)
Repositorio:DIGITAL.CSIC. Repositorio Institucional del CSIC
OAI Identifier:oai:digital.csic.es:10261/195129
Acesso em linha:http://hdl.handle.net/10261/195129
Access Level:acceso abierto
Palavra-chave:Lifespan
Healthspan
Thyroid hormones
Hyperthyroidism
Hypothyroidism
Glucose metabolism
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spelling Inadequate control of thyroid hormones sensitizes to hepatocarcinogenesis and unhealthy agingLópez-Noriega, LiviaCapilla-González, VivianCobo-Vuilleumier, NadiaMartín-Vázquez, EugeniaLorenzo, Petra IsabelMartínez-Force, EnriqueSoriano-Navarro, MarioGarcía-Fernández, MaríaRomero-Zerbo, Silvana Y.Bermúdez-Silva, Francisco JavierDíaz-Contreras, IreneSánchez-Cuesta, AnaSantos-Ocaña, CarlosHmadcha, AbdelkrimSoria Escoms, BernatMartín, FranzGauthier, Benoit R.Martín-Montalvo, AlejandroLifespanHealthspanThyroid hormonesHyperthyroidismHypothyroidismGlucose metabolism34 Páginas.-- 7 Figuras.-- 6 Figuras suplementarias.-- 4 Tablas suplementariasAn inverse correlation between thyroid hormone levels and longevity has been reported in several species and reduced thyroid hormone levels have been proposed as a biomarker for healthy aging and metabolic fitness. However, hypothyroidism is a medical condition associated with compromised health and reduced life expectancy. Herein, we show, using wild-type and the Pax8 ablated model of hypothyroidism in mice, that hyperthyroidism and severe hypothyroidism are associated with an overall unhealthy status and shorter lifespan. Mild hypothyroid Pax8 +/- mice were heavier and displayed insulin resistance, hepatic steatosis and increased prevalence of liver cancer yet had normal lifespan. These pathophysiological conditions were precipitated by hepatic mitochondrial dysfunction and oxidative damage accumulation. These findings indicate that individuals carrying mutations on PAX8 may be susceptible to develop liver cancer and/or diabetes and raise concerns regarding the development of interventions aiming to modulate thyroid hormones to promote healthy aging or lifespan in mammals.This work was funded by grants from the Ministerio de Economía y Competitividad, Instituto de Salud Carlos III co-funded by Fondos FEDER and from the nonprofit foundation ‘Fundación Progreso y Salud’ of the Andalusian Regional Ministry of Health (BFU2017-83588-P to B.R.G; CP14/00105, PI18/01590 and PI15/00134 to A.M-M; PI-0272-2017 and CD16/00118 to V.C-G; PI17/01286 to C. S-O and A. S-C).Peer reviewedImpact JournalsMinisterio de Ciencia, Innovación y Universidades (España)Agencia Estatal de Investigación (España)Instituto de Salud Carlos IIIEuropean CommissionJunta de AndalucíaConsejo Superior de Investigaciones Científicas [https://ror.org/02gfc7t72]201920192019info:eu-repo/semantics/articlehttp://purl.org/coar/resource_type/c_6501Publisher's versioninfo:eu-repo/semantics/publishedVersionhttp://hdl.handle.net/10261/195129reponame:DIGITAL.CSIC. Repositorio Institucional del CSICinstname:Consejo Superior de Investigaciones Científicas (CSIC)Inglés#PLACEHOLDER_PARENT_METADATA_VALUE##PLACEHOLDER_PARENT_METADATA_VALUE#BFU2017-83588-P/AEI/10.13039/501100011033info:eu-repo/grantAgreement/AEI/Plan Estatal de Investigación Científica y Técnica y de Innovación 2017-2020/BFU2017-83588-Phttp://dx.doi.org/10.18632/aging.102285Síinfo:eu-repo/semantics/openAccessoai:digital.csic.es:10261/1951292026-05-22T06:33:51Z
dc.title.none.fl_str_mv Inadequate control of thyroid hormones sensitizes to hepatocarcinogenesis and unhealthy aging
title Inadequate control of thyroid hormones sensitizes to hepatocarcinogenesis and unhealthy aging
spellingShingle Inadequate control of thyroid hormones sensitizes to hepatocarcinogenesis and unhealthy aging
López-Noriega, Livia
Lifespan
Healthspan
Thyroid hormones
Hyperthyroidism
Hypothyroidism
Glucose metabolism
title_short Inadequate control of thyroid hormones sensitizes to hepatocarcinogenesis and unhealthy aging
title_full Inadequate control of thyroid hormones sensitizes to hepatocarcinogenesis and unhealthy aging
title_fullStr Inadequate control of thyroid hormones sensitizes to hepatocarcinogenesis and unhealthy aging
title_full_unstemmed Inadequate control of thyroid hormones sensitizes to hepatocarcinogenesis and unhealthy aging
title_sort Inadequate control of thyroid hormones sensitizes to hepatocarcinogenesis and unhealthy aging
dc.creator.none.fl_str_mv López-Noriega, Livia
Capilla-González, Vivian
Cobo-Vuilleumier, Nadia
Martín-Vázquez, Eugenia
Lorenzo, Petra Isabel
Martínez-Force, Enrique
Soriano-Navarro, Mario
García-Fernández, María
Romero-Zerbo, Silvana Y.
Bermúdez-Silva, Francisco Javier
Díaz-Contreras, Irene
Sánchez-Cuesta, Ana
Santos-Ocaña, Carlos
Hmadcha, Abdelkrim
Soria Escoms, Bernat
Martín, Franz
Gauthier, Benoit R.
Martín-Montalvo, Alejandro
author López-Noriega, Livia
author_facet López-Noriega, Livia
Capilla-González, Vivian
Cobo-Vuilleumier, Nadia
Martín-Vázquez, Eugenia
Lorenzo, Petra Isabel
Martínez-Force, Enrique
Soriano-Navarro, Mario
García-Fernández, María
Romero-Zerbo, Silvana Y.
Bermúdez-Silva, Francisco Javier
Díaz-Contreras, Irene
Sánchez-Cuesta, Ana
Santos-Ocaña, Carlos
Hmadcha, Abdelkrim
Soria Escoms, Bernat
Martín, Franz
Gauthier, Benoit R.
Martín-Montalvo, Alejandro
author_role author
author2 Capilla-González, Vivian
Cobo-Vuilleumier, Nadia
Martín-Vázquez, Eugenia
Lorenzo, Petra Isabel
Martínez-Force, Enrique
Soriano-Navarro, Mario
García-Fernández, María
Romero-Zerbo, Silvana Y.
Bermúdez-Silva, Francisco Javier
Díaz-Contreras, Irene
Sánchez-Cuesta, Ana
Santos-Ocaña, Carlos
Hmadcha, Abdelkrim
Soria Escoms, Bernat
Martín, Franz
Gauthier, Benoit R.
Martín-Montalvo, Alejandro
author2_role author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
dc.contributor.none.fl_str_mv Ministerio de Ciencia, Innovación y Universidades (España)
Agencia Estatal de Investigación (España)
Instituto de Salud Carlos III
European Commission
Junta de Andalucía
Consejo Superior de Investigaciones Científicas [https://ror.org/02gfc7t72]
dc.subject.none.fl_str_mv Lifespan
Healthspan
Thyroid hormones
Hyperthyroidism
Hypothyroidism
Glucose metabolism
topic Lifespan
Healthspan
Thyroid hormones
Hyperthyroidism
Hypothyroidism
Glucose metabolism
description 34 Páginas.-- 7 Figuras.-- 6 Figuras suplementarias.-- 4 Tablas suplementarias
publishDate 2019
dc.date.none.fl_str_mv 2019
2019
2019
dc.type.none.fl_str_mv info:eu-repo/semantics/article
http://purl.org/coar/resource_type/c_6501
Publisher's version
info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/10261/195129
url http://hdl.handle.net/10261/195129
dc.language.none.fl_str_mv Inglés
language_invalid_str_mv Inglés
dc.relation.none.fl_str_mv #PLACEHOLDER_PARENT_METADATA_VALUE#
#PLACEHOLDER_PARENT_METADATA_VALUE#
BFU2017-83588-P/AEI/10.13039/501100011033
info:eu-repo/grantAgreement/AEI/Plan Estatal de Investigación Científica y Técnica y de Innovación 2017-2020/BFU2017-83588-P
http://dx.doi.org/10.18632/aging.102285
Sí
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.publisher.none.fl_str_mv Impact Journals
publisher.none.fl_str_mv Impact Journals
dc.source.none.fl_str_mv reponame:DIGITAL.CSIC. Repositorio Institucional del CSIC
instname:Consejo Superior de Investigaciones Científicas (CSIC)
instname_str Consejo Superior de Investigaciones Científicas (CSIC)
reponame_str DIGITAL.CSIC. Repositorio Institucional del CSIC
collection DIGITAL.CSIC. Repositorio Institucional del CSIC
repository.name.fl_str_mv
repository.mail.fl_str_mv
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score 15,81155

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