Decreased oxytocin plasma levels and oxytocin receptor expression in borderline personality disorder

Introduction: Borderline personality disorder (BPD) is characterized by intense affective reactions with underlying social and interpersonal cognitive deficits. Oxytocin has largely been associated with both stress regulation and social cognition in psychiatric patients and in non-clinical populatio...

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Autores: Buenache, E., De la Vega, I., López‐Villatoro, J. M., Moreno Moreno, Beatriz, Carrasco Perera, José Luis, Mac-Dowell Mata, Karina Soledad, Díaz Marsa, Marina Francisca, Leza Cerro, Juan Carlos
Tipo de recurso: artículo
Fecha de publicación:2020
País:España
Institución:Universidad Complutense de Madrid (UCM)
Repositorio:Docta Complutense
Idioma:inglés
OAI Identifier:oai:docta.ucm.es:20.500.14352/96800
Acceso en línea:https://hdl.handle.net/20.500.14352/96800
Access Level:acceso abierto
Palabra clave:616.89
616.89-007
612.8
Borderline personality disorder
Impulsivity
Oxytocin
Social dysregulation
Ciencias Biomédicas
24 Ciencias de la Vida
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oai_identifier_str oai:docta.ucm.es:20.500.14352/96800
network_acronym_str ES
network_name_str España
repository_id_str
spelling Decreased oxytocin plasma levels and oxytocin receptor expression in borderline personality disorderBuenache, E.De la Vega, I.López‐Villatoro, J. M.Moreno Moreno, BeatrizCarrasco Perera, José LuisMac-Dowell Mata, Karina SoledadDíaz Marsa, Marina FranciscaLeza Cerro, Juan Carlos616.89616.89-007612.8Borderline personality disorderImpulsivityOxytocinSocial dysregulationCiencias Biomédicas24 Ciencias de la VidaIntroduction: Borderline personality disorder (BPD) is characterized by intense affective reactions with underlying social and interpersonal cognitive deficits. Oxytocin has largely been associated with both stress regulation and social cognition in psychiatric patients and in non-clinical populations in previous studies. Finally, abnormal oxytocin levels have been preliminary reported in BPD patients. Methods: 53 patients with moderate-severe BPD and 31 healthy control subjects were investigated for plasma levels of oxytocin and protein expression of oxytocin receptor in blood mononuclear cells. Clinical assessments were made for severity, functionality, and comorbidity with axis I and II conditions. Results: Oxytocin plasma levels were significantly lower in BPD patients compared with controls. In addition, protein expression of oxytocin receptor was significantly reduced in the BPD group. A positive correlation was found between plasma oxytocin levels and the activity index score of the Zuckerman-Kuhlman Personality Questionnaire (ZKPQ). Oxytocin receptor protein expression, on the contrary, had a negative correlation with the ZKPQ sociability index score. Conclusions: Results support the evidence of a dysfunction of the oxytocin system in borderline personality disorder, which could be involved in emotional dysregulation and interpersonal disturbances in these patients.WileyUniversidad Complutense de Madrid20202020-08-1220202020-08-12journal articlehttp://purl.org/coar/resource_type/c_6501AMhttp://purl.org/coar/version/c_ab4af688f83e57aainfo:eu-repo/semantics/articleapplication/pdfhttps://hdl.handle.net/20.500.14352/96800reponame:Docta Complutenseinstname:Universidad Complutense de Madrid (UCM)Inglésengopen accesshttp://purl.org/coar/access_right/c_abf2Attribution-NonCommercial-NoDerivatives 4.0 Internationalhttp://creativecommons.org/licenses/by-nc-nd/4.0/info:eu-repo/semantics/openAccessoai:docta.ucm.es:20.500.14352/968002026-06-02T12:44:21Z
dc.title.none.fl_str_mv Decreased oxytocin plasma levels and oxytocin receptor expression in borderline personality disorder
title Decreased oxytocin plasma levels and oxytocin receptor expression in borderline personality disorder
spellingShingle Decreased oxytocin plasma levels and oxytocin receptor expression in borderline personality disorder
Buenache, E.
616.89
616.89-007
612.8
Borderline personality disorder
Impulsivity
Oxytocin
Social dysregulation
Ciencias Biomédicas
24 Ciencias de la Vida
title_short Decreased oxytocin plasma levels and oxytocin receptor expression in borderline personality disorder
title_full Decreased oxytocin plasma levels and oxytocin receptor expression in borderline personality disorder
title_fullStr Decreased oxytocin plasma levels and oxytocin receptor expression in borderline personality disorder
title_full_unstemmed Decreased oxytocin plasma levels and oxytocin receptor expression in borderline personality disorder
title_sort Decreased oxytocin plasma levels and oxytocin receptor expression in borderline personality disorder
dc.creator.none.fl_str_mv Buenache, E.
De la Vega, I.
López‐Villatoro, J. M.
Moreno Moreno, Beatriz
Carrasco Perera, José Luis
Mac-Dowell Mata, Karina Soledad
Díaz Marsa, Marina Francisca
Leza Cerro, Juan Carlos
author Buenache, E.
author_facet Buenache, E.
De la Vega, I.
López‐Villatoro, J. M.
Moreno Moreno, Beatriz
Carrasco Perera, José Luis
Mac-Dowell Mata, Karina Soledad
Díaz Marsa, Marina Francisca
Leza Cerro, Juan Carlos
author_role author
author2 De la Vega, I.
López‐Villatoro, J. M.
Moreno Moreno, Beatriz
Carrasco Perera, José Luis
Mac-Dowell Mata, Karina Soledad
Díaz Marsa, Marina Francisca
Leza Cerro, Juan Carlos
author2_role author
author
author
author
author
author
author
dc.contributor.none.fl_str_mv Universidad Complutense de Madrid
dc.subject.none.fl_str_mv 616.89
616.89-007
612.8
Borderline personality disorder
Impulsivity
Oxytocin
Social dysregulation
Ciencias Biomédicas
24 Ciencias de la Vida
topic 616.89
616.89-007
612.8
Borderline personality disorder
Impulsivity
Oxytocin
Social dysregulation
Ciencias Biomédicas
24 Ciencias de la Vida
description Introduction: Borderline personality disorder (BPD) is characterized by intense affective reactions with underlying social and interpersonal cognitive deficits. Oxytocin has largely been associated with both stress regulation and social cognition in psychiatric patients and in non-clinical populations in previous studies. Finally, abnormal oxytocin levels have been preliminary reported in BPD patients. Methods: 53 patients with moderate-severe BPD and 31 healthy control subjects were investigated for plasma levels of oxytocin and protein expression of oxytocin receptor in blood mononuclear cells. Clinical assessments were made for severity, functionality, and comorbidity with axis I and II conditions. Results: Oxytocin plasma levels were significantly lower in BPD patients compared with controls. In addition, protein expression of oxytocin receptor was significantly reduced in the BPD group. A positive correlation was found between plasma oxytocin levels and the activity index score of the Zuckerman-Kuhlman Personality Questionnaire (ZKPQ). Oxytocin receptor protein expression, on the contrary, had a negative correlation with the ZKPQ sociability index score. Conclusions: Results support the evidence of a dysfunction of the oxytocin system in borderline personality disorder, which could be involved in emotional dysregulation and interpersonal disturbances in these patients.
publishDate 2020
dc.date.none.fl_str_mv 2020
2020-08-12
2020
2020-08-12
dc.type.none.fl_str_mv journal article
http://purl.org/coar/resource_type/c_6501
AM
http://purl.org/coar/version/c_ab4af688f83e57aa
dc.type.openaire.fl_str_mv info:eu-repo/semantics/article
format article
dc.identifier.none.fl_str_mv https://hdl.handle.net/20.500.14352/96800
url https://hdl.handle.net/20.500.14352/96800
dc.language.none.fl_str_mv Inglés
eng
language_invalid_str_mv Inglés
language eng
dc.rights.none.fl_str_mv open access
http://purl.org/coar/access_right/c_abf2
Attribution-NonCommercial-NoDerivatives 4.0 International
http://creativecommons.org/licenses/by-nc-nd/4.0/
dc.rights.openaire.fl_str_mv info:eu-repo/semantics/openAccess
rights_invalid_str_mv open access
http://purl.org/coar/access_right/c_abf2
Attribution-NonCommercial-NoDerivatives 4.0 International
http://creativecommons.org/licenses/by-nc-nd/4.0/
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv Wiley
publisher.none.fl_str_mv Wiley
dc.source.none.fl_str_mv reponame:Docta Complutense
instname:Universidad Complutense de Madrid (UCM)
instname_str Universidad Complutense de Madrid (UCM)
reponame_str Docta Complutense
collection Docta Complutense
repository.name.fl_str_mv
repository.mail.fl_str_mv
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