One step back before moving forward: regulation of transcription elongation by arrest and backtracking
RNA polymerase II backtracking is a well-known phenomenon, but its involvement in gene regulation is yet to be addressed. Structural studies into the backtracked complex, new reactivation mechanisms and genome-wide approaches are shedding some light on this interesting aspect of gene transcription....
| Authors: | , , , , , , |
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| Format: | article |
| Status: | Published version |
| Publication Date: | 2012 |
| Country: | España |
| Institution: | Universidad de Sevilla (US) |
| Repository: | idUS. Depósito de Investigación de la Universidad de Sevilla |
| OAI Identifier: | oai:idus.us.es:11441/131126 |
| Online Access: | https://hdl.handle.net/11441/131126 https://doi.org/10.1016/j.febslet.2012.07.030 |
| Access Level: | Open access |
| Keyword: | RNA polymerase II Transcription elongation Backtracking TFIIS RNA cleavage Ribosomal protein genes |
| Summary: | RNA polymerase II backtracking is a well-known phenomenon, but its involvement in gene regulation is yet to be addressed. Structural studies into the backtracked complex, new reactivation mechanisms and genome-wide approaches are shedding some light on this interesting aspect of gene transcription. In this review, we briefly summarise these new findings, comment about some results recently obtained in our laboratory, and propose a new model for the influence of the chromatin context on RNA polymerase II backtracking. |
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