Gut microbiota links to serum ferritin and cognition

Iron is required for the replication and growth of almost all bacterial species and in the production of myelin and neurotransmitters. Increasing clinical studies evidence that the gut microbiota plays a critical role in iron metabolism and cognition. However, the understanding of the complex iron-m...

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Autores: Rosell-Díaz, Marisel, Santos-González, Elena, Motger-Albertí, Anna, Ramió i Torrentà, Lluís, Garre Olmo, Josep, Pérez Brocal, Vicente, Moya, Andrés, Jové, Mariona, Pamplona, Reinald, Puig Alcántara, Josep, Ramos Blanes, Rafel, Fernández-Real Lemos, José Manuel, Mayneris Perxachs, Jordi
Tipo de recurso: artículo
Estado:Versión publicada
Fecha de publicación:2023
País:España
Institución:Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)
Repositorio:Recercat. Dipósit de la Recerca de Catalunya
OAI Identifier:oai:recercat.cat:10256/24251
Acceso en línea:http://hdl.handle.net/10256/24251
Access Level:acceso abierto
Palabra clave:Cognició
Cognition
Intestins -- Microbiologia
Intestines -- Microbiology
Epidemiologia
Epidemiology
Ferritina
Ferritin
Ferro en l'organisme
Iron in the body
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spelling Gut microbiota links to serum ferritin and cognitionRosell-Díaz, MariselSantos-González, ElenaMotger-Albertí, AnnaRamió i Torrentà, LluísGarre Olmo, JosepPérez Brocal, VicenteMoya, AndrésJové, MarionaPamplona, ReinaldPuig Alcántara, JosepRamos Blanes, RafelFernández-Real Lemos, José ManuelMayneris Perxachs, JordiCognicióCognitionIntestins -- MicrobiologiaIntestines -- MicrobiologyEpidemiologiaEpidemiologyFerritinaFerritinFerro en l'organismeIron in the bodyIron is required for the replication and growth of almost all bacterial species and in the production of myelin and neurotransmitters. Increasing clinical studies evidence that the gut microbiota plays a critical role in iron metabolism and cognition. However, the understanding of the complex iron-microbiome-cognition crosstalk remains elusive. In a recent study in the Aging Imageomics cohort (n = 1,030), we identified a positive association of serum ferritin (SF) with executive function (EF) as inferred from the semantic verbal fluency (SVF,) the total digit span (TDS) and the phonemic verbal fluency tests (PVF). Here, we explored the potential mechanisms by analyzing the gut microbiome and plasma metabolome using shotgun metagenomics and HPLC-ESI-MS/MS, respectively. Different bacterial species belonging to the Proteobacteria phylum (Klebsiella pneumoniae, Klebsiella michiganensis, Unclassified Escherichia) were negatively associated both with SF and executive function. At the functional level, an enrichment of microbial pathways involved in phenylalanine, arginine, and proline metabolism was identified. Consistently, phenylacetylglutamine, a metabolite derived from microbial catabolism of phenylalanine, was negatively associated with SF, EF, and semantic memory. Other metabolites such as ureidobutyric acid and 19,20-DiHDPA, a DHA-derived oxylipin, were also consistently and negatively associated with SF, EF, and semantic memory, while plasma eicosapentaenoic acid was positively associated. The associations of SF with cognition could be mediated by the gut microbiome through microbial-derived metabolitesTaylor&Francis2023info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionpeer-reviewedapplication/pdfhttp://hdl.handle.net/10256/24251Gut Microbes, 2023, vol. 15, núm. 2, p. 2290318Articles publicats (D-CM)Rosell-Díaz, Marisel Santos-González, Elena Motger-Albertí, Anna Ramió i Torrentà, Lluís Garre Olmo, Josep Pérez Brocal, Vicente Moya, Andrés Jové, Mariona Pamplona, Reinald Puig Alcántara, Josep Ramos Blanes, Rafel Fernández-Real Lemos, José Manuel Mayneris-Perxachs J. 2023 Gut microbiota links to serum ferritin and cognition Gut Microbes 15 2 2290318reponame:Recercat. Dipósit de la Recerca de Catalunyainstname:Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)Inglésinfo:eu-repo/semantics/altIdentifier/doi/10.1080/19490976.2023.2290318info:eu-repo/semantics/altIdentifier/issn/1949-0976info:eu-repo/semantics/altIdentifier/eissn/1949-0984Reconeixement-NoComercial 4.0 Internacionalhttp://creativecommons.org/licenses/by-nc/4.0info:eu-repo/semantics/openAccessoai:recercat.cat:10256/242512026-05-29T05:05:01Z
dc.title.none.fl_str_mv Gut microbiota links to serum ferritin and cognition
title Gut microbiota links to serum ferritin and cognition
spellingShingle Gut microbiota links to serum ferritin and cognition
Rosell-Díaz, Marisel
Cognició
Cognition
Intestins -- Microbiologia
Intestines -- Microbiology
Epidemiologia
Epidemiology
Ferritina
Ferritin
Ferro en l'organisme
Iron in the body
title_short Gut microbiota links to serum ferritin and cognition
title_full Gut microbiota links to serum ferritin and cognition
title_fullStr Gut microbiota links to serum ferritin and cognition
title_full_unstemmed Gut microbiota links to serum ferritin and cognition
title_sort Gut microbiota links to serum ferritin and cognition
dc.creator.none.fl_str_mv Rosell-Díaz, Marisel
Santos-González, Elena
Motger-Albertí, Anna
Ramió i Torrentà, Lluís
Garre Olmo, Josep
Pérez Brocal, Vicente
Moya, Andrés
Jové, Mariona
Pamplona, Reinald
Puig Alcántara, Josep
Ramos Blanes, Rafel
Fernández-Real Lemos, José Manuel
Mayneris Perxachs, Jordi
author Rosell-Díaz, Marisel
author_facet Rosell-Díaz, Marisel
Santos-González, Elena
Motger-Albertí, Anna
Ramió i Torrentà, Lluís
Garre Olmo, Josep
Pérez Brocal, Vicente
Moya, Andrés
Jové, Mariona
Pamplona, Reinald
Puig Alcántara, Josep
Ramos Blanes, Rafel
Fernández-Real Lemos, José Manuel
Mayneris Perxachs, Jordi
author_role author
author2 Santos-González, Elena
Motger-Albertí, Anna
Ramió i Torrentà, Lluís
Garre Olmo, Josep
Pérez Brocal, Vicente
Moya, Andrés
Jové, Mariona
Pamplona, Reinald
Puig Alcántara, Josep
Ramos Blanes, Rafel
Fernández-Real Lemos, José Manuel
Mayneris Perxachs, Jordi
author2_role author
author
author
author
author
author
author
author
author
author
author
author
dc.subject.none.fl_str_mv Cognició
Cognition
Intestins -- Microbiologia
Intestines -- Microbiology
Epidemiologia
Epidemiology
Ferritina
Ferritin
Ferro en l'organisme
Iron in the body
topic Cognició
Cognition
Intestins -- Microbiologia
Intestines -- Microbiology
Epidemiologia
Epidemiology
Ferritina
Ferritin
Ferro en l'organisme
Iron in the body
description Iron is required for the replication and growth of almost all bacterial species and in the production of myelin and neurotransmitters. Increasing clinical studies evidence that the gut microbiota plays a critical role in iron metabolism and cognition. However, the understanding of the complex iron-microbiome-cognition crosstalk remains elusive. In a recent study in the Aging Imageomics cohort (n = 1,030), we identified a positive association of serum ferritin (SF) with executive function (EF) as inferred from the semantic verbal fluency (SVF,) the total digit span (TDS) and the phonemic verbal fluency tests (PVF). Here, we explored the potential mechanisms by analyzing the gut microbiome and plasma metabolome using shotgun metagenomics and HPLC-ESI-MS/MS, respectively. Different bacterial species belonging to the Proteobacteria phylum (Klebsiella pneumoniae, Klebsiella michiganensis, Unclassified Escherichia) were negatively associated both with SF and executive function. At the functional level, an enrichment of microbial pathways involved in phenylalanine, arginine, and proline metabolism was identified. Consistently, phenylacetylglutamine, a metabolite derived from microbial catabolism of phenylalanine, was negatively associated with SF, EF, and semantic memory. Other metabolites such as ureidobutyric acid and 19,20-DiHDPA, a DHA-derived oxylipin, were also consistently and negatively associated with SF, EF, and semantic memory, while plasma eicosapentaenoic acid was positively associated. The associations of SF with cognition could be mediated by the gut microbiome through microbial-derived metabolites
publishDate 2023
dc.date.none.fl_str_mv 2023
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
peer-reviewed
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/10256/24251
url http://hdl.handle.net/10256/24251
dc.language.none.fl_str_mv Inglés
language_invalid_str_mv Inglés
dc.relation.none.fl_str_mv info:eu-repo/semantics/altIdentifier/doi/10.1080/19490976.2023.2290318
info:eu-repo/semantics/altIdentifier/issn/1949-0976
info:eu-repo/semantics/altIdentifier/eissn/1949-0984
dc.rights.none.fl_str_mv Reconeixement-NoComercial 4.0 Internacional
http://creativecommons.org/licenses/by-nc/4.0
info:eu-repo/semantics/openAccess
rights_invalid_str_mv Reconeixement-NoComercial 4.0 Internacional
http://creativecommons.org/licenses/by-nc/4.0
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv Taylor&Francis
publisher.none.fl_str_mv Taylor&Francis
dc.source.none.fl_str_mv Gut Microbes, 2023, vol. 15, núm. 2, p. 2290318
Articles publicats (D-CM)
Rosell-Díaz, Marisel Santos-González, Elena Motger-Albertí, Anna Ramió i Torrentà, Lluís Garre Olmo, Josep Pérez Brocal, Vicente Moya, Andrés Jové, Mariona Pamplona, Reinald Puig Alcántara, Josep Ramos Blanes, Rafel Fernández-Real Lemos, José Manuel Mayneris-Perxachs J. 2023 Gut microbiota links to serum ferritin and cognition Gut Microbes 15 2 2290318
reponame:Recercat. Dipósit de la Recerca de Catalunya
instname:Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)
instname_str Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)
reponame_str Recercat. Dipósit de la Recerca de Catalunya
collection Recercat. Dipósit de la Recerca de Catalunya
repository.name.fl_str_mv
repository.mail.fl_str_mv
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score 15,811543

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