Organs-on-Chips: Trends and Challenges in Advanced Systems Integration

Organ-on-chip platforms combined with high-throughput sensing technology allow bridging gaps in information presented by 2D cultures modeled on static microphysiological systems. While these platforms do not aim to replicate whole organ systems with all physiological nuances, they try to mimic relev...

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Autores: Mughal, Sheeza, López Muñoz, Gerardo A., Fernández Costa, Juan M., Cortés Reséndiz, Armando, Chiara, Francesco de, Ramón Azcón, Javier
Tipo de recurso: artículo
Estado:Versión aceptada para publicación
Fecha de publicación:2022
País:España
Institución:Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)
Repositorio:Recercat. Dipósit de la Recerca de Catalunya
OAI Identifier:oai:recercat.cat:2445/199385
Acceso en línea:https://hdl.handle.net/2445/199385
Access Level:acceso abierto
Palabra clave:Bioenginyeria
Cultiu cel·lular
Bioengineering
Cell culture
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spelling Organs-on-Chips: Trends and Challenges in Advanced Systems IntegrationMughal, SheezaLópez Muñoz, Gerardo A.Fernández Costa, Juan M.Cortés Reséndiz, ArmandoChiara, Francesco deRamón Azcón, JavierBioenginyeriaCultiu cel·lularBioengineeringCell cultureOrgan-on-chip platforms combined with high-throughput sensing technology allow bridging gaps in information presented by 2D cultures modeled on static microphysiological systems. While these platforms do not aim to replicate whole organ systems with all physiological nuances, they try to mimic relevant structural, physiological, and functional features of organoids and tissues to best model disease and/or healthy states. The advent of this platform has not only challenged animal testing but has also presented the opportunity to acquire real-time, high-throughput data about the pathophysiology of disease progression by employing biosensors. Biosensors allow monitoring of the release of relevant biomarkers and metabolites as a result of physicochemical stress. It, therefore, helps conduct quick lead validation to achieve personalized medicine objectives. The organ-on-chip industry is currently embarking on an exponential growth trajectory. Multiple pharmaceutical and biotechnology companies are adopting this technology to enable quick patient-specific data acquisition at substantially low costs.Wiley2023202320222023info:eu-repo/semantics/articleinfo:eu-repo/semantics/acceptedVersion30 p.application/pdfhttps://hdl.handle.net/2445/199385Articles publicats en revistes (Institut de Bioenginyeria de Catalunya (IBEC))reponame:Recercat. Dipósit de la Recerca de Catalunyainstname:Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)InglésPostprint del document publicat a: https://doi.org/10.1002/admi.202201618Advanced Materials Interfaces, 2022, vol. 9https://doi.org/10.1002/admi.202201618(c) Wiley, 2022info:eu-repo/semantics/openAccessoai:recercat.cat:2445/1993852026-05-29T05:05:01Z
dc.title.none.fl_str_mv Organs-on-Chips: Trends and Challenges in Advanced Systems Integration
title Organs-on-Chips: Trends and Challenges in Advanced Systems Integration
spellingShingle Organs-on-Chips: Trends and Challenges in Advanced Systems Integration
Mughal, Sheeza
Bioenginyeria
Cultiu cel·lular
Bioengineering
Cell culture
title_short Organs-on-Chips: Trends and Challenges in Advanced Systems Integration
title_full Organs-on-Chips: Trends and Challenges in Advanced Systems Integration
title_fullStr Organs-on-Chips: Trends and Challenges in Advanced Systems Integration
title_full_unstemmed Organs-on-Chips: Trends and Challenges in Advanced Systems Integration
title_sort Organs-on-Chips: Trends and Challenges in Advanced Systems Integration
dc.creator.none.fl_str_mv Mughal, Sheeza
López Muñoz, Gerardo A.
Fernández Costa, Juan M.
Cortés Reséndiz, Armando
Chiara, Francesco de
Ramón Azcón, Javier
author Mughal, Sheeza
author_facet Mughal, Sheeza
López Muñoz, Gerardo A.
Fernández Costa, Juan M.
Cortés Reséndiz, Armando
Chiara, Francesco de
Ramón Azcón, Javier
author_role author
author2 López Muñoz, Gerardo A.
Fernández Costa, Juan M.
Cortés Reséndiz, Armando
Chiara, Francesco de
Ramón Azcón, Javier
author2_role author
author
author
author
author
dc.subject.none.fl_str_mv Bioenginyeria
Cultiu cel·lular
Bioengineering
Cell culture
topic Bioenginyeria
Cultiu cel·lular
Bioengineering
Cell culture
description Organ-on-chip platforms combined with high-throughput sensing technology allow bridging gaps in information presented by 2D cultures modeled on static microphysiological systems. While these platforms do not aim to replicate whole organ systems with all physiological nuances, they try to mimic relevant structural, physiological, and functional features of organoids and tissues to best model disease and/or healthy states. The advent of this platform has not only challenged animal testing but has also presented the opportunity to acquire real-time, high-throughput data about the pathophysiology of disease progression by employing biosensors. Biosensors allow monitoring of the release of relevant biomarkers and metabolites as a result of physicochemical stress. It, therefore, helps conduct quick lead validation to achieve personalized medicine objectives. The organ-on-chip industry is currently embarking on an exponential growth trajectory. Multiple pharmaceutical and biotechnology companies are adopting this technology to enable quick patient-specific data acquisition at substantially low costs.
publishDate 2022
dc.date.none.fl_str_mv 2022
2023
2023
2023
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/acceptedVersion
format article
status_str acceptedVersion
dc.identifier.none.fl_str_mv https://hdl.handle.net/2445/199385
url https://hdl.handle.net/2445/199385
dc.language.none.fl_str_mv Inglés
language_invalid_str_mv Inglés
dc.relation.none.fl_str_mv Postprint del document publicat a: https://doi.org/10.1002/admi.202201618
Advanced Materials Interfaces, 2022, vol. 9
https://doi.org/10.1002/admi.202201618
dc.rights.none.fl_str_mv (c) Wiley, 2022
info:eu-repo/semantics/openAccess
rights_invalid_str_mv (c) Wiley, 2022
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv 30 p.
application/pdf
dc.publisher.none.fl_str_mv Wiley
publisher.none.fl_str_mv Wiley
dc.source.none.fl_str_mv Articles publicats en revistes (Institut de Bioenginyeria de Catalunya (IBEC))
reponame:Recercat. Dipósit de la Recerca de Catalunya
instname:Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)
instname_str Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)
reponame_str Recercat. Dipósit de la Recerca de Catalunya
collection Recercat. Dipósit de la Recerca de Catalunya
repository.name.fl_str_mv
repository.mail.fl_str_mv
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score 15,81155

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