Synthesis of novel nucleoside analogues built on a bicyclo[4.1.0]heptane scaffold
A new class of carbocyclic nucleoside analogues built on a bicyclo[4.1.0]heptane scaffold, a perspective novel pseudosugar pattern, have been conceived as anti-HSV agents on the basis of initial protein-ligand docking studies. The asymmetric synthesis of a series of these compounds incorporating dif...
| Autores: | , , , , , , |
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| Tipo de recurso: | artículo |
| Fecha de publicación: | 2015 |
| País: | España |
| Institución: | Universitat Autònoma de Barcelona |
| Repositorio: | Dipòsit Digital de Documents de la UAB |
| Idioma: | inglés |
| OAI Identifier: | oai:ddd.uab.cat:279309 |
| Acceso en línea: | https://ddd.uab.cat/record/279309 https://dx.doi.org/urn:doi:10.1021/acs.joc.5b01413 |
| Access Level: | acceso abierto |
| Palabra clave: | Alcohols Antimicrobial agents Hydrocarbons Nucleic acids Peptides and proteins |
| Sumario: | A new class of carbocyclic nucleoside analogues built on a bicyclo[4.1.0]heptane scaffold, a perspective novel pseudosugar pattern, have been conceived as anti-HSV agents on the basis of initial protein-ligand docking studies. The asymmetric synthesis of a series of these compounds incorporating different nucleobases has been efficiently completed starting from 1,4-cyclohexanedione. |
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