Aggregation behaviour of biohybrid microgels from elastin-like recombinamers

Producción Científica

Detalhes bibliográficos
Autores: Singh, Smriti, Rahimi, Khosrow, Fechete, Radu, Rodríguez Cabello, José Carlos, Möller, Martin
Tipo de documento: artigo
Data de publicação:2016
País:España
Recursos:Universidad de Valladolid
Repositório:UVaDOC. Repositorio Documental de la Universidad de Valladolid
OAI Identifier:oai:uvadoc.uva.es:10324/24800
Acesso em linha:https://doi.org/10.1039/C6SM00954A
http://uvadoc.uva.es/handle/10324/24800
Access Level:Acceso aberto
Palavra-chave:Agregación de microgeles biohíbridos
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spelling Aggregation behaviour of biohybrid microgels from elastin-like recombinamersSingh, SmritiRahimi, KhosrowFechete, RaduRodríguez Cabello, José CarlosMöller, MartinAgregación de microgeles biohíbridosProducción CientíficaInvestigation of the aggregation behavior of biohybrid microgels, which can potentially be used as drug carriers, is an important topic, because aggregation not only causes loss of activity, but also toxicity and immunogenicity. To study this effect we synthesized microgels from elastin-like recombinamers (ELRs) using the miniemulsion technique. The existence of aggregation for such biohybrid microgels at different concentrations and temperatures was studied by different methods which include dynamic light scattering (DLS), 1H high-resolution magic angle sample spinning (HRMAS) NMR spectroscopy, relaxometry and diffusometry. A hysteresis effect was detected in the process of aggregation by DLS as a function of temperature that strongly depends on ELR microgel concentration. The aggregation process was further quantitatively analyzed by the concentration dependence of the 1H amino-acid residue chemical shifts and microgel diffusivity measured by NMR methods using the population balance kinetic aggregation model.Ministerio de Industria, Economía y Competitividad (proyectos MAT2013-42473-R y MAT2013-41723-R).Royal Society of Chemistry2016info:eu-repo/semantics/articleapplication/pdfhttps://doi.org/10.1039/C6SM00954Ahttp://uvadoc.uva.es/handle/10324/24800reponame:UVaDOC. Repositorio Documental de la Universidad de Valladolidinstname:Universidad de ValladolidIngléshttp://pubs.rsc.org/en/content/articlelanding/2016/sm/c6sm00954ainfo:eu-repo/grantAgreement/EC/H2020/642687info:eu-repo/semantics/openAccesshttp://creativecommons.org/licenses/by-nc-nd/4.0/oai:uvadoc.uva.es:10324/248002026-06-13T12:44:47Z
dc.title.none.fl_str_mv Aggregation behaviour of biohybrid microgels from elastin-like recombinamers
title Aggregation behaviour of biohybrid microgels from elastin-like recombinamers
spellingShingle Aggregation behaviour of biohybrid microgels from elastin-like recombinamers
Singh, Smriti
Agregación de microgeles biohíbridos
title_short Aggregation behaviour of biohybrid microgels from elastin-like recombinamers
title_full Aggregation behaviour of biohybrid microgels from elastin-like recombinamers
title_fullStr Aggregation behaviour of biohybrid microgels from elastin-like recombinamers
title_full_unstemmed Aggregation behaviour of biohybrid microgels from elastin-like recombinamers
title_sort Aggregation behaviour of biohybrid microgels from elastin-like recombinamers
dc.creator.none.fl_str_mv Singh, Smriti
Rahimi, Khosrow
Fechete, Radu
Rodríguez Cabello, José Carlos
Möller, Martin
author Singh, Smriti
author_facet Singh, Smriti
Rahimi, Khosrow
Fechete, Radu
Rodríguez Cabello, José Carlos
Möller, Martin
author_role author
author2 Rahimi, Khosrow
Fechete, Radu
Rodríguez Cabello, José Carlos
Möller, Martin
author2_role author
author
author
author
dc.subject.none.fl_str_mv Agregación de microgeles biohíbridos
topic Agregación de microgeles biohíbridos
description Producción Científica
publishDate 2016
dc.date.none.fl_str_mv 2016
dc.type.none.fl_str_mv info:eu-repo/semantics/article
format article
dc.identifier.none.fl_str_mv https://doi.org/10.1039/C6SM00954A
http://uvadoc.uva.es/handle/10324/24800
url https://doi.org/10.1039/C6SM00954A
http://uvadoc.uva.es/handle/10324/24800
dc.language.none.fl_str_mv Inglés
language_invalid_str_mv Inglés
dc.relation.none.fl_str_mv http://pubs.rsc.org/en/content/articlelanding/2016/sm/c6sm00954a
info:eu-repo/grantAgreement/EC/H2020/642687
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
http://creativecommons.org/licenses/by-nc-nd/4.0/
eu_rights_str_mv openAccess
rights_invalid_str_mv http://creativecommons.org/licenses/by-nc-nd/4.0/
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv Royal Society of Chemistry
publisher.none.fl_str_mv Royal Society of Chemistry
dc.source.none.fl_str_mv reponame:UVaDOC. Repositorio Documental de la Universidad de Valladolid
instname:Universidad de Valladolid
instname_str Universidad de Valladolid
reponame_str UVaDOC. Repositorio Documental de la Universidad de Valladolid
collection UVaDOC. Repositorio Documental de la Universidad de Valladolid
repository.name.fl_str_mv
repository.mail.fl_str_mv
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