Mortality and bleeding complications of CoVID-19 critically ill patients with venous thromboembolism

Background: Venous thromboembolism (VTE) disease in COVID-19 patients is a remarkable issue, especially its relationship with bleeding events and mortality. The objective of this study was to describe the outcomes of critically ill patients with COVID-19, hospitalized in the Intensive Care Unit (ICU...

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Autores: Gil-Sala, Daniel|||0000-0003-4885-5836, Riera, Clàudia, García Reyes, Marvin Ernesto|||0000-0001-8813-9987, Rodríguez, Manuela, Marrero, Carlos, Martínez, Lucia|||0000-0002-2941-0922, Gil Olaria, Miquel|||0000-0001-9628-6071, Ruiz-Rodriguez, Juan Carlos|||0000-0001-7392-8617, Ferrer, Ricard|||0000-0002-4859-4747, Nadal Clanchet, Miriam de|||0000-0002-4559-2463, Suito Alcántara, Milagros A., Llagostera Pujol, Secundino|||0000-0003-3895-5761, Bellmunt Montoya, Sergi|||0000-0002-2851-720X
Tipo de recurso: artículo
Fecha de publicación:2022
País:España
Institución:Universitat Autònoma de Barcelona
Repositorio:Dipòsit Digital de Documents de la UAB
Idioma:inglés
OAI Identifier:oai:dnet:uabarcelona_::b4a97f0ab5fe90c744f9ebc48a94f03c
Acceso en línea:https://ddd.uab.cat/record/328419
https://dx.doi.org/urn:doi:10.23736/S0392-9590.21.04704-0
Access Level:acceso abierto
Palabra clave:SARS-CoV-2 infection
COVID19
Venous thromboembolism
Deep venous thrombosis
Mortality
Bleeding
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spelling Mortality and bleeding complications of CoVID-19 critically ill patients with venous thromboembolismGil-Sala, Daniel|||0000-0003-4885-5836Riera, ClàudiaGarcía Reyes, Marvin Ernesto|||0000-0001-8813-9987Rodríguez, ManuelaMarrero, CarlosMartínez, Lucia|||0000-0002-2941-0922Gil Olaria, Miquel|||0000-0001-9628-6071Ruiz-Rodriguez, Juan Carlos|||0000-0001-7392-8617Ferrer, Ricard|||0000-0002-4859-4747Nadal Clanchet, Miriam de|||0000-0002-4559-2463Suito Alcántara, Milagros A.Llagostera Pujol, Secundino|||0000-0003-3895-5761Bellmunt Montoya, Sergi|||0000-0002-2851-720XSARS-CoV-2 infectionCOVID19Venous thromboembolismDeep venous thrombosisMortalityBleedingBackground: Venous thromboembolism (VTE) disease in COVID-19 patients is a remarkable issue, especially its relationship with bleeding events and mortality. The objective of this study was to describe the outcomes of critically ill patients with COVID-19, hospitalized in the Intensive Care Unit (ICU), in relationship with VTE during their stay. Methods: This is a prospective cohort study of critically ill COVID-19 patients in two hospitals that underwent a venous ultrasound at the beginning of follow-up of both lower limbs in April 2020. In case of clinical suspicion of new VTE during the 30-day follow-up, additional ultrasound or thoracic CT were performed. Global VTE frequency, major bleeding events and survival were collected, and their predictors were studied. Results: We included 230 patients. After 30 days of follow-up, there were 95 VTE events in 86 patients (37.4%). Thirteen patients (5.7%) developed major bleeding complications and 42 patients (18.3%) died. None of the comorbidities or previous treatments were related with bleeding events. D-Dimer at admission was significantly related with VTE development and mortality. Independent predictors of mortality in the regression model were older age (>66 years), D-Dimer at admission (>1.500 ng/mL) and low lymphocyte count (<0.45×10/L) with an AUC in the ROC curve of 0.81 (95% CI: 0.73-0.89). Patients presenting these three conditions presented a mortality of 100% in the predictive model. Conclusions: VTE frequency in ICU COVID-19 patients is high and risk of major bleeding is low. Comorbidities and laboratory parameters of admission in these patients can be a useful tool to predict mortality. 22022-01-0120222022-01-01Articlehttp://purl.org/coar/resource_type/c_6501AMhttp://purl.org/coar/version/c_ab4af688f83e57aainfo:eu-repo/semantics/articleapplication/pdfhttps://ddd.uab.cat/record/328419https://dx.doi.org/urn:doi:10.23736/S0392-9590.21.04704-0reponame:Dipòsit Digital de Documents de la UABinstname:Universitat Autònoma de BarcelonaInglésengopen accesshttp://purl.org/coar/access_right/c_abf2Aquest material està protegit per drets d'autor i/o drets afins. Podeu utilitzar aquest material en funció del que permet la legislació de drets d'autor i drets afins d'aplicació al vostre cas. Per a d'altres usos heu d'obtenir permís del(s) titular(s) de drets.https://rightsstatements.org/vocab/InC/1.0/info:eu-repo/semantics/openAccessoai:dnet:uabarcelona_::b4a97f0ab5fe90c744f9ebc48a94f03c2026-06-06T12:50:31Z
dc.title.none.fl_str_mv Mortality and bleeding complications of CoVID-19 critically ill patients with venous thromboembolism
title Mortality and bleeding complications of CoVID-19 critically ill patients with venous thromboembolism
spellingShingle Mortality and bleeding complications of CoVID-19 critically ill patients with venous thromboembolism
Gil-Sala, Daniel|||0000-0003-4885-5836
SARS-CoV-2 infection
COVID19
Venous thromboembolism
Deep venous thrombosis
Mortality
Bleeding
title_short Mortality and bleeding complications of CoVID-19 critically ill patients with venous thromboembolism
title_full Mortality and bleeding complications of CoVID-19 critically ill patients with venous thromboembolism
title_fullStr Mortality and bleeding complications of CoVID-19 critically ill patients with venous thromboembolism
title_full_unstemmed Mortality and bleeding complications of CoVID-19 critically ill patients with venous thromboembolism
title_sort Mortality and bleeding complications of CoVID-19 critically ill patients with venous thromboembolism
dc.creator.none.fl_str_mv Gil-Sala, Daniel|||0000-0003-4885-5836
Riera, Clàudia
García Reyes, Marvin Ernesto|||0000-0001-8813-9987
Rodríguez, Manuela
Marrero, Carlos
Martínez, Lucia|||0000-0002-2941-0922
Gil Olaria, Miquel|||0000-0001-9628-6071
Ruiz-Rodriguez, Juan Carlos|||0000-0001-7392-8617
Ferrer, Ricard|||0000-0002-4859-4747
Nadal Clanchet, Miriam de|||0000-0002-4559-2463
Suito Alcántara, Milagros A.
Llagostera Pujol, Secundino|||0000-0003-3895-5761
Bellmunt Montoya, Sergi|||0000-0002-2851-720X
author Gil-Sala, Daniel|||0000-0003-4885-5836
author_facet Gil-Sala, Daniel|||0000-0003-4885-5836
Riera, Clàudia
García Reyes, Marvin Ernesto|||0000-0001-8813-9987
Rodríguez, Manuela
Marrero, Carlos
Martínez, Lucia|||0000-0002-2941-0922
Gil Olaria, Miquel|||0000-0001-9628-6071
Ruiz-Rodriguez, Juan Carlos|||0000-0001-7392-8617
Ferrer, Ricard|||0000-0002-4859-4747
Nadal Clanchet, Miriam de|||0000-0002-4559-2463
Suito Alcántara, Milagros A.
Llagostera Pujol, Secundino|||0000-0003-3895-5761
Bellmunt Montoya, Sergi|||0000-0002-2851-720X
author_role author
author2 Riera, Clàudia
García Reyes, Marvin Ernesto|||0000-0001-8813-9987
Rodríguez, Manuela
Marrero, Carlos
Martínez, Lucia|||0000-0002-2941-0922
Gil Olaria, Miquel|||0000-0001-9628-6071
Ruiz-Rodriguez, Juan Carlos|||0000-0001-7392-8617
Ferrer, Ricard|||0000-0002-4859-4747
Nadal Clanchet, Miriam de|||0000-0002-4559-2463
Suito Alcántara, Milagros A.
Llagostera Pujol, Secundino|||0000-0003-3895-5761
Bellmunt Montoya, Sergi|||0000-0002-2851-720X
author2_role author
author
author
author
author
author
author
author
author
author
author
author
dc.subject.none.fl_str_mv SARS-CoV-2 infection
COVID19
Venous thromboembolism
Deep venous thrombosis
Mortality
Bleeding
topic SARS-CoV-2 infection
COVID19
Venous thromboembolism
Deep venous thrombosis
Mortality
Bleeding
description Background: Venous thromboembolism (VTE) disease in COVID-19 patients is a remarkable issue, especially its relationship with bleeding events and mortality. The objective of this study was to describe the outcomes of critically ill patients with COVID-19, hospitalized in the Intensive Care Unit (ICU), in relationship with VTE during their stay. Methods: This is a prospective cohort study of critically ill COVID-19 patients in two hospitals that underwent a venous ultrasound at the beginning of follow-up of both lower limbs in April 2020. In case of clinical suspicion of new VTE during the 30-day follow-up, additional ultrasound or thoracic CT were performed. Global VTE frequency, major bleeding events and survival were collected, and their predictors were studied. Results: We included 230 patients. After 30 days of follow-up, there were 95 VTE events in 86 patients (37.4%). Thirteen patients (5.7%) developed major bleeding complications and 42 patients (18.3%) died. None of the comorbidities or previous treatments were related with bleeding events. D-Dimer at admission was significantly related with VTE development and mortality. Independent predictors of mortality in the regression model were older age (>66 years), D-Dimer at admission (>1.500 ng/mL) and low lymphocyte count (<0.45×10/L) with an AUC in the ROC curve of 0.81 (95% CI: 0.73-0.89). Patients presenting these three conditions presented a mortality of 100% in the predictive model. Conclusions: VTE frequency in ICU COVID-19 patients is high and risk of major bleeding is low. Comorbidities and laboratory parameters of admission in these patients can be a useful tool to predict mortality.
publishDate 2022
dc.date.none.fl_str_mv 2
2022-01-01
2022
2022-01-01
dc.type.none.fl_str_mv Article
http://purl.org/coar/resource_type/c_6501
AM
http://purl.org/coar/version/c_ab4af688f83e57aa
dc.type.openaire.fl_str_mv info:eu-repo/semantics/article
format article
dc.identifier.none.fl_str_mv https://ddd.uab.cat/record/328419
https://dx.doi.org/urn:doi:10.23736/S0392-9590.21.04704-0
url https://ddd.uab.cat/record/328419
https://dx.doi.org/urn:doi:10.23736/S0392-9590.21.04704-0
dc.language.none.fl_str_mv Inglés
eng
language_invalid_str_mv Inglés
language eng
dc.rights.none.fl_str_mv open access
http://purl.org/coar/access_right/c_abf2
https://rightsstatements.org/vocab/InC/1.0/
dc.rights.openaire.fl_str_mv info:eu-repo/semantics/openAccess
rights_invalid_str_mv open access
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eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.source.none.fl_str_mv reponame:Dipòsit Digital de Documents de la UAB
instname:Universitat Autònoma de Barcelona
instname_str Universitat Autònoma de Barcelona
reponame_str Dipòsit Digital de Documents de la UAB
collection Dipòsit Digital de Documents de la UAB
repository.name.fl_str_mv
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