The role of dietary patterns and inflammation in breast cancer risk and survival
[eng] INTRODUCTION: Factors like body fatness and physical activity, influenced by diet, are associated with both breast cancer and low-grade chronic inflammation. The direct link between breast cancer and inflammatory processes, as well as the impact of modulating these processes through diet, rema...
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| Tipo de recurso: | tesis doctoral |
| Estado: | Versión publicada |
| Fecha de publicación: | 2023 |
| País: | España |
| Institución: | Universidad de Barcelona |
| Repositorio: | Dipòsit Digital de la UB |
| OAI Identifier: | oai:diposit.ub.edu:2445/220336 |
| Acceso en línea: | https://hdl.handle.net/2445/220336 http://hdl.handle.net/10803/694213 |
| Access Level: | acceso abierto |
| Palabra clave: | Càncer de mama Inflamació Epidemiologia Dietètica Breast cancer Inflammation Epidemiology Dietetics |
| Sumario: | [eng] INTRODUCTION: Factors like body fatness and physical activity, influenced by diet, are associated with both breast cancer and low-grade chronic inflammation. The direct link between breast cancer and inflammatory processes, as well as the impact of modulating these processes through diet, remains uncertain. Studying diet’s potential to affect chronic inflammation and other biological processes can provide insights for better dietary strategies in breast cancer prevention and survival. Additionally, investigating the connection between inflammatory biomarkers and breast cancer survival complements dietary pattern research and enhances our understanding of molecular mechanisms, especially those related to inflammation. HYPOTHESES: We suggest that diets capable of modulating low-grade chronic inflammation may exert an impact on the risk and prognosis of breast cancer. In addition, we hypothesise that adherence to dietary patterns related to other underlying mechanisms associated with breast carcinogenesis, such as insulin resistance or oestrogen metabolism, can impact on breast cancer survival. We also hypothesise that the Mediterranean diet may underscore beneficial biological mechanisms that could impact on a better prognosis of breast cancer survivors. We suggest that elevated levels of inflammatory markers could influence the «latent» inflammation that precedes cancer and have an impact on breast cancer prognosis. OBJECTIVES: To evaluate the association between the inflammatory potential of the diet, by means of the inflammatory score of the diet (ISD), and the risk and survival of breast cancer. To examine the association between other dietary patterns related to biological mechanism, such as the Diabetes Risk Reduction Diet (DRRD) and the Estrogen-Related Dietary Pattern (ERDP), and cancer mortality among breast cancer survivors. To assess the relationship with breast cancer survival with a more traditional dietary pattern, the Mediterranean diet. To investigate the association between pre-diagnosis inflammatory biomarkers and breast cancer survival. To examine all these associations according to menopausal status, hormone receptor status, and tumour stage. |
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