Human papillomavirus detection from human immunodeficiency virus-infected Colombian women’s paired urine and cervical samples

Infection, coinfection and type-specific human papillomavirus (HPV) distribution was evaluated in human immunodeficiency virus (HIV)-positive women from paired cervical and urine samples. Paired cervical and urine samples (n = 204) were taken from HIV-positive women for identifying HPV-DNA presence...

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Autores: Muñoz Bobo, Marina, Camargo, Milena, Soto de León, Sara, Sánchez, Ricardo, Parra, Diana, Pineda Peña, Andrea, Sussmann, Otto, Pérez Prados, Antonio, Patarroyo, Manuel Elkin, Patarroyo, Manuel Alfonso
Tipo de recurso: artículo
Estado:Versión publicada
Fecha de publicación:2013
País:España
Institución:Universidad Pública de Navarra
Repositorio:Academica-e. Repositorio Institucional de la Universidad Pública de Navarra
OAI Identifier:oai:academica-e.unavarra.es:2454/23537
Acceso en línea:https://hdl.handle.net/2454/23537
Access Level:acceso abierto
Palabra clave:Human papillomavirus (HPV)
HIV
Urine samples
Cervical samples
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spelling Human papillomavirus detection from human immunodeficiency virus-infected Colombian women’s paired urine and cervical samplesMuñoz Bobo, MarinaCamargo, MilenaSoto de León, SaraSánchez, RicardoParra, DianaPineda Peña, AndreaSussmann, OttoPérez Prados, AntonioPatarroyo, Manuel ElkinPatarroyo, Manuel AlfonsoHuman papillomavirus (HPV)HIVUrine samplesCervical samplesInfection, coinfection and type-specific human papillomavirus (HPV) distribution was evaluated in human immunodeficiency virus (HIV)-positive women from paired cervical and urine samples. Paired cervical and urine samples (n = 204) were taken from HIV-positive women for identifying HPV-DNA presence by using polymerase chain reaction (PCR) with three generic primer sets (GP5+/6+, MY09/11 and pU1M/2R). HPV-positive samples were typed for six high-risk HPV (HR-HPV) (HPV-16, -18, -31, -33, -45 and -58) and two low-risk (LR-HPV) (HPV-6/11) types. Agreement between paired sample results and diagnostic performance was evaluated. HPV infection prevalence was 70.6% in cervical and 63.2% in urine samples. HPV-16 was the most prevalent HPV type in both types of sample (66.7% in cervical samples and 62.0% in urine) followed by HPV-31(47.2%) in cervical samples and HPV-58 (35.7%) in urine samples. There was 55.4% coinfection (infection by more than one type of HPV) in cervical samples and 40.2% in urine samples. Abnormal Papanicolau smears were observed in 25.3% of the women, presenting significant association with HPV-DNA being identified in urine samples. There was poor agreement of cervical and urine sample results in generic and type-specific detection of HPV. Urine samples provided the best diagnosis when taking cytological findings as reference. In conclusion including urine samples could be a good strategy for ensuring adherence to screening programs aimed at reducing the impact of cervical cancer, since this sample is easy to obtain and showed good diagnostic performance.This project was funded by the Basque Cooperation Agency Development and by the Spanish Agency for International Development Cooperation (AECID).PLOSEstadística e Investigación OperativaEstatistika eta Ikerketa Operatiboa2013info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionapplication/pdfhttps://hdl.handle.net/2454/23537reponame:Academica-e. Repositorio Institucional de la Universidad Pública de Navarrainstname:Universidad Pública de NavarraInglés© 2013 Muñoz et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.https://creativecommons.org/licenses/by/3.0/info:eu-repo/semantics/openAccessoai:academica-e.unavarra.es:2454/235372026-06-17T12:41:47Z
dc.title.none.fl_str_mv Human papillomavirus detection from human immunodeficiency virus-infected Colombian women’s paired urine and cervical samples
title Human papillomavirus detection from human immunodeficiency virus-infected Colombian women’s paired urine and cervical samples
spellingShingle Human papillomavirus detection from human immunodeficiency virus-infected Colombian women’s paired urine and cervical samples
Muñoz Bobo, Marina
Human papillomavirus (HPV)
HIV
Urine samples
Cervical samples
title_short Human papillomavirus detection from human immunodeficiency virus-infected Colombian women’s paired urine and cervical samples
title_full Human papillomavirus detection from human immunodeficiency virus-infected Colombian women’s paired urine and cervical samples
title_fullStr Human papillomavirus detection from human immunodeficiency virus-infected Colombian women’s paired urine and cervical samples
title_full_unstemmed Human papillomavirus detection from human immunodeficiency virus-infected Colombian women’s paired urine and cervical samples
title_sort Human papillomavirus detection from human immunodeficiency virus-infected Colombian women’s paired urine and cervical samples
dc.creator.none.fl_str_mv Muñoz Bobo, Marina
Camargo, Milena
Soto de León, Sara
Sánchez, Ricardo
Parra, Diana
Pineda Peña, Andrea
Sussmann, Otto
Pérez Prados, Antonio
Patarroyo, Manuel Elkin
Patarroyo, Manuel Alfonso
author Muñoz Bobo, Marina
author_facet Muñoz Bobo, Marina
Camargo, Milena
Soto de León, Sara
Sánchez, Ricardo
Parra, Diana
Pineda Peña, Andrea
Sussmann, Otto
Pérez Prados, Antonio
Patarroyo, Manuel Elkin
Patarroyo, Manuel Alfonso
author_role author
author2 Camargo, Milena
Soto de León, Sara
Sánchez, Ricardo
Parra, Diana
Pineda Peña, Andrea
Sussmann, Otto
Pérez Prados, Antonio
Patarroyo, Manuel Elkin
Patarroyo, Manuel Alfonso
author2_role author
author
author
author
author
author
author
author
author
dc.contributor.none.fl_str_mv Estadística e Investigación Operativa
Estatistika eta Ikerketa Operatiboa
dc.subject.none.fl_str_mv Human papillomavirus (HPV)
HIV
Urine samples
Cervical samples
topic Human papillomavirus (HPV)
HIV
Urine samples
Cervical samples
description Infection, coinfection and type-specific human papillomavirus (HPV) distribution was evaluated in human immunodeficiency virus (HIV)-positive women from paired cervical and urine samples. Paired cervical and urine samples (n = 204) were taken from HIV-positive women for identifying HPV-DNA presence by using polymerase chain reaction (PCR) with three generic primer sets (GP5+/6+, MY09/11 and pU1M/2R). HPV-positive samples were typed for six high-risk HPV (HR-HPV) (HPV-16, -18, -31, -33, -45 and -58) and two low-risk (LR-HPV) (HPV-6/11) types. Agreement between paired sample results and diagnostic performance was evaluated. HPV infection prevalence was 70.6% in cervical and 63.2% in urine samples. HPV-16 was the most prevalent HPV type in both types of sample (66.7% in cervical samples and 62.0% in urine) followed by HPV-31(47.2%) in cervical samples and HPV-58 (35.7%) in urine samples. There was 55.4% coinfection (infection by more than one type of HPV) in cervical samples and 40.2% in urine samples. Abnormal Papanicolau smears were observed in 25.3% of the women, presenting significant association with HPV-DNA being identified in urine samples. There was poor agreement of cervical and urine sample results in generic and type-specific detection of HPV. Urine samples provided the best diagnosis when taking cytological findings as reference. In conclusion including urine samples could be a good strategy for ensuring adherence to screening programs aimed at reducing the impact of cervical cancer, since this sample is easy to obtain and showed good diagnostic performance.
publishDate 2013
dc.date.none.fl_str_mv 2013
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv https://hdl.handle.net/2454/23537
url https://hdl.handle.net/2454/23537
dc.language.none.fl_str_mv Inglés
language_invalid_str_mv Inglés
dc.rights.none.fl_str_mv https://creativecommons.org/licenses/by/3.0/
info:eu-repo/semantics/openAccess
rights_invalid_str_mv https://creativecommons.org/licenses/by/3.0/
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv PLOS
publisher.none.fl_str_mv PLOS
dc.source.none.fl_str_mv reponame:Academica-e. Repositorio Institucional de la Universidad Pública de Navarra
instname:Universidad Pública de Navarra
instname_str Universidad Pública de Navarra
reponame_str Academica-e. Repositorio Institucional de la Universidad Pública de Navarra
collection Academica-e. Repositorio Institucional de la Universidad Pública de Navarra
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repository.mail.fl_str_mv
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