Variations in activation energy and nuclei size during nucleation explain chiral symmetry breaking

We show that variations in enantiomer nuclei size and activation energy during the nucleation stage of crystallization are responsible for the chiral symmetry breaking resulting in excess of one of the possible enantiomers with respect to the other. By understanding the crystallisation process as a...

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Detalhes bibliográficos
Autores: Arango-Restrepo, Andrés, Barragán, D., Rubí Capaceti, José Miguel
Formato: artículo
Estado:Versión publicada
Fecha de publicación:2023
País:España
Recursos:Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)
Repositorio:Recercat. Dipósit de la Recerca de Catalunya
OAI Identifier:oai:recercat.cat:2445/217080
Acesso em linha:https://hdl.handle.net/2445/217080
Access Level:acceso abierto
Palavra-chave:Energia
Termodinàmica
Quiralitat
Energy
Thermodynamics
Chirality
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repository_id_str
spelling Variations in activation energy and nuclei size during nucleation explain chiral symmetry breakingArango-Restrepo, AndrésBarragán, D.Rubí Capaceti, José MiguelEnergiaTermodinàmicaQuiralitatEnergyThermodynamicsChiralityWe show that variations in enantiomer nuclei size and activation energy during the nucleation stage of crystallization are responsible for the chiral symmetry breaking resulting in excess of one of the possible enantiomers with respect to the other. By understanding the crystallisation process as a non-equilibrium self-assembly process, we quantify the enantiomeric excess through the probability distribution of the nuclei size and activation energy variations which are obtained from the free energy involved in the nucleation stage of crystallisation. We validate our theory by comparing it to Kondepudi et al. previous experimental work on sodium chlorate crystallisation. The results demonstrate that the self-assembly of enantiomeric crystals provides an explanation for chiral symmetry breaking. These findings could have practical applications for improving the production of enantiopure drugs in the pharmaceutical industry, as well as for enhancing our understanding of the origins of life since enantiomeric amino acids and monosaccharides are the building blocks of life.Royal Society of Chemistry2024202420232024info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersion1 p.application/pdfhttps://hdl.handle.net/2445/217080Articles publicats en revistes (Física de la Matèria Condensada)reponame:Recercat. Dipósit de la Recerca de Catalunyainstname:Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)InglésReproducció del document publicat a: https://doi.org/10.1039/D3CP03220EPhysical Chemistry Chemical Physics, 2023https://doi.org/10.1039/D3CP03220Ecc-by-nc (c) A. Arango-Restrepo et al., 2023http://creativecommons.org/licenses/by-nc/3.0/es/info:eu-repo/semantics/openAccessoai:recercat.cat:2445/2170802026-05-29T05:05:01Z
dc.title.none.fl_str_mv Variations in activation energy and nuclei size during nucleation explain chiral symmetry breaking
title Variations in activation energy and nuclei size during nucleation explain chiral symmetry breaking
spellingShingle Variations in activation energy and nuclei size during nucleation explain chiral symmetry breaking
Arango-Restrepo, Andrés
Energia
Termodinàmica
Quiralitat
Energy
Thermodynamics
Chirality
title_short Variations in activation energy and nuclei size during nucleation explain chiral symmetry breaking
title_full Variations in activation energy and nuclei size during nucleation explain chiral symmetry breaking
title_fullStr Variations in activation energy and nuclei size during nucleation explain chiral symmetry breaking
title_full_unstemmed Variations in activation energy and nuclei size during nucleation explain chiral symmetry breaking
title_sort Variations in activation energy and nuclei size during nucleation explain chiral symmetry breaking
dc.creator.none.fl_str_mv Arango-Restrepo, Andrés
Barragán, D.
Rubí Capaceti, José Miguel
author Arango-Restrepo, Andrés
author_facet Arango-Restrepo, Andrés
Barragán, D.
Rubí Capaceti, José Miguel
author_role author
author2 Barragán, D.
Rubí Capaceti, José Miguel
author2_role author
author
dc.subject.none.fl_str_mv Energia
Termodinàmica
Quiralitat
Energy
Thermodynamics
Chirality
topic Energia
Termodinàmica
Quiralitat
Energy
Thermodynamics
Chirality
description We show that variations in enantiomer nuclei size and activation energy during the nucleation stage of crystallization are responsible for the chiral symmetry breaking resulting in excess of one of the possible enantiomers with respect to the other. By understanding the crystallisation process as a non-equilibrium self-assembly process, we quantify the enantiomeric excess through the probability distribution of the nuclei size and activation energy variations which are obtained from the free energy involved in the nucleation stage of crystallisation. We validate our theory by comparing it to Kondepudi et al. previous experimental work on sodium chlorate crystallisation. The results demonstrate that the self-assembly of enantiomeric crystals provides an explanation for chiral symmetry breaking. These findings could have practical applications for improving the production of enantiopure drugs in the pharmaceutical industry, as well as for enhancing our understanding of the origins of life since enantiomeric amino acids and monosaccharides are the building blocks of life.
publishDate 2023
dc.date.none.fl_str_mv 2023
2024
2024
2024
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv https://hdl.handle.net/2445/217080
url https://hdl.handle.net/2445/217080
dc.language.none.fl_str_mv Inglés
language_invalid_str_mv Inglés
dc.relation.none.fl_str_mv Reproducció del document publicat a: https://doi.org/10.1039/D3CP03220E
Physical Chemistry Chemical Physics, 2023
https://doi.org/10.1039/D3CP03220E
dc.rights.none.fl_str_mv cc-by-nc (c) A. Arango-Restrepo et al., 2023
http://creativecommons.org/licenses/by-nc/3.0/es/
info:eu-repo/semantics/openAccess
rights_invalid_str_mv cc-by-nc (c) A. Arango-Restrepo et al., 2023
http://creativecommons.org/licenses/by-nc/3.0/es/
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv 1 p.
application/pdf
dc.publisher.none.fl_str_mv Royal Society of Chemistry
publisher.none.fl_str_mv Royal Society of Chemistry
dc.source.none.fl_str_mv Articles publicats en revistes (Física de la Matèria Condensada)
reponame:Recercat. Dipósit de la Recerca de Catalunya
instname:Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)
instname_str Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)
reponame_str Recercat. Dipósit de la Recerca de Catalunya
collection Recercat. Dipósit de la Recerca de Catalunya
repository.name.fl_str_mv
repository.mail.fl_str_mv
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score 15.811543

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