The Contribution of Astrocyte Autophagy to Systemic Metabolism

© 2020 by the authors.

Detalles Bibliográficos
Autores: Ortiz-Rodriguez, Ana, Arévalo, María Ángeles
Tipo de recurso: artículo
Estado:Versión publicada
Fecha de publicación:2020
País:España
Institución:Consejo Superior de Investigaciones Científicas (CSIC)
Repositorio:DIGITAL.CSIC. Repositorio Institucional del CSIC
OAI Identifier:oai:digital.csic.es:10261/207701
Acceso en línea:http://hdl.handle.net/10261/207701
Access Level:acceso abierto
Palabra clave:Astrocytes
Autophagy
Hypothalamus
Metabolism
Obesity
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spelling The Contribution of Astrocyte Autophagy to Systemic MetabolismOrtiz-Rodriguez, AnaArévalo, María ÁngelesAstrocytesAutophagyHypothalamusMetabolismObesity© 2020 by the authors.Autophagy is an essential mechanism to maintain cellular homeostasis. Besides its role in controlling the quality of cytoplasmic components, it participates in nutrient obtaining and lipid mobilization under stressful conditions. Furthermore, autophagy is involved in the regulation of systemic metabolism as its blockade in hypothalamic neurons can affect the central regulation of metabolism and impact body energy balance. Moreover, hypothalamic autophagy can be altered during obesity, one of the main alterations of metabolism nowadays. In this review, we focus on the role of astrocytes, essential cells for brain homeostasis, which represent key metabolic regulators. Astrocytes can sense metabolic signals in the hypothalamus and modulate systemic functions as glucose homeostasis and feeding response. Moreover, the response of astrocytes to obesity has been widely studied. Astrocytes are important mediators of brain inflammation and can be affected by increased levels of saturated fatty acids associated with obesity. Although autophagy plays important roles for astrocyte homeostasis and functioning, the contribution of astrocyte autophagy to systemic metabolism has not been analyzed yet. Furthermore, how obesity can impact astrocyte autophagy is poorly understood. More studies are needed in order to understand the contribution of astrocyte autophagy to metabolism.This research was funded by Agencia Estatal de Investigación (AEI), co-funded by Fondo Europeo de Desarrollo Regional (FEDER), grant number BFU2017-82754-R and by Centro de Investigación Biomédica en red (CIBERFES).Peer reviewedMultidisciplinary Digital Publishing InstituteMinisterio de Ciencia, Innovación y Universidades (España)Agencia Estatal de Investigación (España)Consejo Superior de Investigaciones Científicas [https://ror.org/02gfc7t72]2020202020202020info:eu-repo/semantics/articlehttp://purl.org/coar/resource_type/c_6501Publisher's versioninfo:eu-repo/semantics/publishedVersionhttp://hdl.handle.net/10261/207701reponame:DIGITAL.CSIC. Repositorio Institucional del CSICinstname:Consejo Superior de Investigaciones Científicas (CSIC)Inglés#PLACEHOLDER_PARENT_METADATA_VALUE##PLACEHOLDER_PARENT_METADATA_VALUE#info:eu-repo/grantAgreement/AEI/Plan Estatal de Investigación Científica y Técnica y de Innovación 2017-2020/BFU2017-82754-RBFU2017-82754-R/AEI/10.13039/501100011033https://doi.org/10.3390/ijms21072479Síinfo:eu-repo/semantics/openAccessoai:digital.csic.es:10261/2077012026-05-22T06:33:51Z
dc.title.none.fl_str_mv The Contribution of Astrocyte Autophagy to Systemic Metabolism
title The Contribution of Astrocyte Autophagy to Systemic Metabolism
spellingShingle The Contribution of Astrocyte Autophagy to Systemic Metabolism
Ortiz-Rodriguez, Ana
Astrocytes
Autophagy
Hypothalamus
Metabolism
Obesity
title_short The Contribution of Astrocyte Autophagy to Systemic Metabolism
title_full The Contribution of Astrocyte Autophagy to Systemic Metabolism
title_fullStr The Contribution of Astrocyte Autophagy to Systemic Metabolism
title_full_unstemmed The Contribution of Astrocyte Autophagy to Systemic Metabolism
title_sort The Contribution of Astrocyte Autophagy to Systemic Metabolism
dc.creator.none.fl_str_mv Ortiz-Rodriguez, Ana
Arévalo, María Ángeles
author Ortiz-Rodriguez, Ana
author_facet Ortiz-Rodriguez, Ana
Arévalo, María Ángeles
author_role author
author2 Arévalo, María Ángeles
author2_role author
dc.contributor.none.fl_str_mv Ministerio de Ciencia, Innovación y Universidades (España)
Agencia Estatal de Investigación (España)
Consejo Superior de Investigaciones Científicas [https://ror.org/02gfc7t72]
dc.subject.none.fl_str_mv Astrocytes
Autophagy
Hypothalamus
Metabolism
Obesity
topic Astrocytes
Autophagy
Hypothalamus
Metabolism
Obesity
description © 2020 by the authors.
publishDate 2020
dc.date.none.fl_str_mv 2020
2020
2020
2020
dc.type.none.fl_str_mv info:eu-repo/semantics/article
http://purl.org/coar/resource_type/c_6501
Publisher's version
info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/10261/207701
url http://hdl.handle.net/10261/207701
dc.language.none.fl_str_mv Inglés
language_invalid_str_mv Inglés
dc.relation.none.fl_str_mv #PLACEHOLDER_PARENT_METADATA_VALUE#
#PLACEHOLDER_PARENT_METADATA_VALUE#
info:eu-repo/grantAgreement/AEI/Plan Estatal de Investigación Científica y Técnica y de Innovación 2017-2020/BFU2017-82754-R
BFU2017-82754-R/AEI/10.13039/501100011033
https://doi.org/10.3390/ijms21072479
Sí
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.publisher.none.fl_str_mv Multidisciplinary Digital Publishing Institute
publisher.none.fl_str_mv Multidisciplinary Digital Publishing Institute
dc.source.none.fl_str_mv reponame:DIGITAL.CSIC. Repositorio Institucional del CSIC
instname:Consejo Superior de Investigaciones Científicas (CSIC)
instname_str Consejo Superior de Investigaciones Científicas (CSIC)
reponame_str DIGITAL.CSIC. Repositorio Institucional del CSIC
collection DIGITAL.CSIC. Repositorio Institucional del CSIC
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