Lifetime bipolar disorder comorbidity and related clinical characteristics in patients with primary obsessive compulsive disorder: a report from the International College of Obsessive-Compulsive Spectrum Disorders (ICOCS)

Introduction. Bipolar disorder (BD) and obsessive compulsive disorder (OCD) are prevalent, comorbid, and disabling conditions, often characterized by early onset and chronic course. When comorbid, OCD and BD can determine a more pernicious course of illness, posing therapeutic challenges for clinici...

Descripción completa

Detalles Bibliográficos
Autores: Dell'Osso, Bernardo, Vismara, Matteo, Benatti, Beatrice, Cirnigliaro, Giovanna, Grancini, Benedetta, Fineberg, Naomi A., Van Ameringen, Michael, Hollander, Eric, 1957-, Stein, Dan J., Menchón Magriñá, José Manuel, Rodriguez, Carolyn I., Nicolini, Humberto, Lanzagorta, Nuria, Pallanti, Stefano, Grassi, Giacomo, Lochner, Christine, Marazziti, Donatella, Hranov, Georgi, Karamustafalioglu, Oguz, Hranov, Luchezar, Zohar, Joseph
Tipo de recurso: artículo
Estado:Versión aceptada para publicación
Fecha de publicación:2020
País:España
Institución:Universidad de Barcelona
Repositorio:Dipòsit Digital de la UB
OAI Identifier:oai:diposit.ub.edu:2445/171947
Acceso en línea:https://hdl.handle.net/2445/171947
Access Level:acceso abierto
Palabra clave:Trastorn bipolar
Neurosi obsessiva
Comorbiditat
Manic-depressive illness
Obsessive-compulsive disorder
Comorbidity
Descripción
Sumario:Introduction. Bipolar disorder (BD) and obsessive compulsive disorder (OCD) are prevalent, comorbid, and disabling conditions, often characterized by early onset and chronic course. When comorbid, OCD and BD can determine a more pernicious course of illness, posing therapeutic challenges for clinicians. Available reports on prevalence and clinical characteristics of comorbidity between BD and OCD showed mixed results, likely depending on the primary diagnosis of analyzed samples. Methods. We assessed prevalence and clinical characteristics of BD comorbidity in a large international sample of patients with primary OCD (n = 401), through the International College of Obsessive-Compulsive Spectrum Disorders (ICOCS) snapshot database, by comparing OCD subjects with vs without BD comorbidity. Results. Among primary OCD patients, 6.2% showed comorbidity with BD. OCD patients with vs without BD comorbidity more frequently had a previous hospitalization (p < 0.001) and current augmentation therapies (p < 0.001). They also showed greater severity of OCD (p < 0.001), as measured by the Yale-Brown Obsessive Compulsive Scale (Y-BOCS). Conclusion. These findings from a large international sample indicate that approximately 1 out of 16 patients with primary OCD may additionally have BD comorbidity along with other specific clinical characteristics, including more frequent previous hospitalizations, more complex therapeutic regimens, and a greater severity of OCD. Prospective international studies are needed to confirm our findings.

Similares en LA Referencia