Neuroprotective effects of dexamethasone in a neuromelanin-driven parkinson’s disease model

Parkinson's disease (PD) is characterized by the progressive loss of dopaminergic neurons in the substantia nigra that primarily affects movement control. Neuroinflammation plays a pivotal role in driving the disease's progression. The persistent inflammatory state in the brain exacerbates...

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Autores: Garcia-Gomara, M. (M.)|||/items/bca88074-28f4-4ebc-946a-ab25108d3124, Juan-Palencia, A. (A.)|||/items/c674f0f3-09f3-4c6a-b548-8a451ec80625, Alfaro, M. (Maite)|||/items/e2960df2-a8d9-4612-b779-896e91b176b6, Cuadrado-Tejedor, M. (Mar)|||/items/8e19b277-1821-4ae8-9617-975de11dbdd1, Garcia-Osta, A. (Ana)|||/items/6a828922-d55a-4aca-9dec-ccfb2a7380f8
Tipo de recurso: artículo
Fecha de publicación:2024
País:España
Institución:Universidad de Navarra
Repositorio:Dadun. Depósito Académico Digital de la Universidad de Navarra
Idioma:inglés
OAI Identifier:oai:dadun.unav.edu:10171/116204
Acceso en línea:https://hdl.handle.net/10171/116204
Access Level:acceso abierto
Palabra clave:Corticoids
Dexamethasone
Neuroinflammation
Neuromelanin
Parkinson’s disease
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spelling Neuroprotective effects of dexamethasone in a neuromelanin-driven parkinson’s disease modelGarcia-Gomara, M. (M.)|||/items/bca88074-28f4-4ebc-946a-ab25108d3124Juan-Palencia, A. (A.)|||/items/c674f0f3-09f3-4c6a-b548-8a451ec80625Alfaro, M. (Maite)|||/items/e2960df2-a8d9-4612-b779-896e91b176b6Cuadrado-Tejedor, M. (Mar)|||/items/8e19b277-1821-4ae8-9617-975de11dbdd1Garcia-Osta, A. (Ana)|||/items/6a828922-d55a-4aca-9dec-ccfb2a7380f8CorticoidsDexamethasoneNeuroinflammationNeuromelaninParkinson’s diseaseParkinson's disease (PD) is characterized by the progressive loss of dopaminergic neurons in the substantia nigra that primarily affects movement control. Neuroinflammation plays a pivotal role in driving the disease's progression. The persistent inflammatory state in the brain exacerbates neuronal damage, creating a cycle that perpetuates the neurodegenerative process. Glucocorticoids, such as dexamethasone, have potent anti-inflammatory properties and have been studied for their neuroprotective potential in different neurodegenerative diseases. However, their specific impact on PD remains unclear. This study aimed to evaluate the impact of dexamethasone on a neuromelanin (NM)-driven model of PD. We demonstrated that dexamethasone administration significantly improved motor function and preserved dopaminergic neuron compared to untreated controls in our study. These neuroprotective effects were mediated, at least in part, by suppressing reactive microglia and reducing the infiltration of peripheral immune cells into the brain. Our findings underscore the potential therapeutic benefits of dexamethasone in mitigating neuroinflammation and maintaining neuronal integrity in a NM-driven model of PD. These results advocate for further investigation into glucocorticoid-based therapies as adjunctive treatments for PD, particularly in scenarios where neuroinflammation contributes prominently to disease progression.Springer NatureDadun. Depósito Académico Digital Universidad de Navarra20242024-01-0120242024-01-01journal articlehttp://purl.org/coar/resource_type/c_6501info:eu-repo/semantics/articleapplication/pdfhttps://hdl.handle.net/10171/116204reponame:Dadun. Depósito Académico Digital de la Universidad de Navarrainstname:Universidad de NavarraInglésengopen accesshttp://purl.org/coar/access_right/c_abf2info:eu-repo/semantics/openAccessoai:dadun.unav.edu:10171/1162042026-06-21T12:47:57Z
dc.title.none.fl_str_mv Neuroprotective effects of dexamethasone in a neuromelanin-driven parkinson’s disease model
title Neuroprotective effects of dexamethasone in a neuromelanin-driven parkinson’s disease model
spellingShingle Neuroprotective effects of dexamethasone in a neuromelanin-driven parkinson’s disease model
Garcia-Gomara, M. (M.)|||/items/bca88074-28f4-4ebc-946a-ab25108d3124
Corticoids
Dexamethasone
Neuroinflammation
Neuromelanin
Parkinson’s disease
title_short Neuroprotective effects of dexamethasone in a neuromelanin-driven parkinson’s disease model
title_full Neuroprotective effects of dexamethasone in a neuromelanin-driven parkinson’s disease model
title_fullStr Neuroprotective effects of dexamethasone in a neuromelanin-driven parkinson’s disease model
title_full_unstemmed Neuroprotective effects of dexamethasone in a neuromelanin-driven parkinson’s disease model
title_sort Neuroprotective effects of dexamethasone in a neuromelanin-driven parkinson’s disease model
dc.creator.none.fl_str_mv Garcia-Gomara, M. (M.)|||/items/bca88074-28f4-4ebc-946a-ab25108d3124
Juan-Palencia, A. (A.)|||/items/c674f0f3-09f3-4c6a-b548-8a451ec80625
Alfaro, M. (Maite)|||/items/e2960df2-a8d9-4612-b779-896e91b176b6
Cuadrado-Tejedor, M. (Mar)|||/items/8e19b277-1821-4ae8-9617-975de11dbdd1
Garcia-Osta, A. (Ana)|||/items/6a828922-d55a-4aca-9dec-ccfb2a7380f8
author Garcia-Gomara, M. (M.)|||/items/bca88074-28f4-4ebc-946a-ab25108d3124
author_facet Garcia-Gomara, M. (M.)|||/items/bca88074-28f4-4ebc-946a-ab25108d3124
Juan-Palencia, A. (A.)|||/items/c674f0f3-09f3-4c6a-b548-8a451ec80625
Alfaro, M. (Maite)|||/items/e2960df2-a8d9-4612-b779-896e91b176b6
Cuadrado-Tejedor, M. (Mar)|||/items/8e19b277-1821-4ae8-9617-975de11dbdd1
Garcia-Osta, A. (Ana)|||/items/6a828922-d55a-4aca-9dec-ccfb2a7380f8
author_role author
author2 Juan-Palencia, A. (A.)|||/items/c674f0f3-09f3-4c6a-b548-8a451ec80625
Alfaro, M. (Maite)|||/items/e2960df2-a8d9-4612-b779-896e91b176b6
Cuadrado-Tejedor, M. (Mar)|||/items/8e19b277-1821-4ae8-9617-975de11dbdd1
Garcia-Osta, A. (Ana)|||/items/6a828922-d55a-4aca-9dec-ccfb2a7380f8
author2_role author
author
author
author
dc.contributor.none.fl_str_mv Dadun. Depósito Académico Digital Universidad de Navarra
dc.subject.none.fl_str_mv Corticoids
Dexamethasone
Neuroinflammation
Neuromelanin
Parkinson’s disease
topic Corticoids
Dexamethasone
Neuroinflammation
Neuromelanin
Parkinson’s disease
description Parkinson's disease (PD) is characterized by the progressive loss of dopaminergic neurons in the substantia nigra that primarily affects movement control. Neuroinflammation plays a pivotal role in driving the disease's progression. The persistent inflammatory state in the brain exacerbates neuronal damage, creating a cycle that perpetuates the neurodegenerative process. Glucocorticoids, such as dexamethasone, have potent anti-inflammatory properties and have been studied for their neuroprotective potential in different neurodegenerative diseases. However, their specific impact on PD remains unclear. This study aimed to evaluate the impact of dexamethasone on a neuromelanin (NM)-driven model of PD. We demonstrated that dexamethasone administration significantly improved motor function and preserved dopaminergic neuron compared to untreated controls in our study. These neuroprotective effects were mediated, at least in part, by suppressing reactive microglia and reducing the infiltration of peripheral immune cells into the brain. Our findings underscore the potential therapeutic benefits of dexamethasone in mitigating neuroinflammation and maintaining neuronal integrity in a NM-driven model of PD. These results advocate for further investigation into glucocorticoid-based therapies as adjunctive treatments for PD, particularly in scenarios where neuroinflammation contributes prominently to disease progression.
publishDate 2024
dc.date.none.fl_str_mv 2024
2024-01-01
2024
2024-01-01
dc.type.none.fl_str_mv journal article
http://purl.org/coar/resource_type/c_6501
dc.type.openaire.fl_str_mv info:eu-repo/semantics/article
format article
dc.identifier.none.fl_str_mv https://hdl.handle.net/10171/116204
url https://hdl.handle.net/10171/116204
dc.language.none.fl_str_mv Inglés
eng
language_invalid_str_mv Inglés
language eng
dc.rights.none.fl_str_mv open access
http://purl.org/coar/access_right/c_abf2
dc.rights.openaire.fl_str_mv info:eu-repo/semantics/openAccess
rights_invalid_str_mv open access
http://purl.org/coar/access_right/c_abf2
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv Springer Nature
publisher.none.fl_str_mv Springer Nature
dc.source.none.fl_str_mv reponame:Dadun. Depósito Académico Digital de la Universidad de Navarra
instname:Universidad de Navarra
instname_str Universidad de Navarra
reponame_str Dadun. Depósito Académico Digital de la Universidad de Navarra
collection Dadun. Depósito Académico Digital de la Universidad de Navarra
repository.name.fl_str_mv
repository.mail.fl_str_mv
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