Revisiting the Metabolic Capabilities of Bifidobacterium longum susbp. longum and Bifidobacterium longum subsp. infantis from a Glycoside Hydrolase Perspective

© 2020 by the authors.

Detalles Bibliográficos
Autores: Blanco González, Guillermo, Ruíz García, Lorena, Tamés, Hector, Ruas-Madiedo, Patricia, Fdez-Riverola, Florentino, Sánchez García, Borja, Lourenço, Anália, Margolles Barros, Abelardo
Tipo de recurso: artículo
Estado:Versión publicada
Fecha de publicación:2020
País:España
Institución:Consejo Superior de Investigaciones Científicas (CSIC)
Repositorio:DIGITAL.CSIC. Repositorio Institucional del CSIC
OAI Identifier:oai:digital.csic.es:10261/212540
Acceso en línea:http://hdl.handle.net/10261/212540
Access Level:acceso abierto
Palabra clave:Bifidobacterium
Longum
Infantis
Carbohydrates
Glycoside hydrolases
Computational screening
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repository_id_str
dc.title.none.fl_str_mv Revisiting the Metabolic Capabilities of Bifidobacterium longum susbp. longum and Bifidobacterium longum subsp. infantis from a Glycoside Hydrolase Perspective
title Revisiting the Metabolic Capabilities of Bifidobacterium longum susbp. longum and Bifidobacterium longum subsp. infantis from a Glycoside Hydrolase Perspective
spellingShingle Revisiting the Metabolic Capabilities of Bifidobacterium longum susbp. longum and Bifidobacterium longum subsp. infantis from a Glycoside Hydrolase Perspective
Blanco González, Guillermo
Bifidobacterium
Longum
Infantis
Carbohydrates
Glycoside hydrolases
Computational screening
title_short Revisiting the Metabolic Capabilities of Bifidobacterium longum susbp. longum and Bifidobacterium longum subsp. infantis from a Glycoside Hydrolase Perspective
title_full Revisiting the Metabolic Capabilities of Bifidobacterium longum susbp. longum and Bifidobacterium longum subsp. infantis from a Glycoside Hydrolase Perspective
title_fullStr Revisiting the Metabolic Capabilities of Bifidobacterium longum susbp. longum and Bifidobacterium longum subsp. infantis from a Glycoside Hydrolase Perspective
title_full_unstemmed Revisiting the Metabolic Capabilities of Bifidobacterium longum susbp. longum and Bifidobacterium longum subsp. infantis from a Glycoside Hydrolase Perspective
title_sort Revisiting the Metabolic Capabilities of Bifidobacterium longum susbp. longum and Bifidobacterium longum subsp. infantis from a Glycoside Hydrolase Perspective
dc.creator.none.fl_str_mv Blanco González, Guillermo
Ruíz García, Lorena
Tamés, Hector
Ruas-Madiedo, Patricia
Fdez-Riverola, Florentino
Sánchez García, Borja
Lourenço, Anália
Margolles Barros, Abelardo
author Blanco González, Guillermo
author_facet Blanco González, Guillermo
Ruíz García, Lorena
Tamés, Hector
Ruas-Madiedo, Patricia
Fdez-Riverola, Florentino
Sánchez García, Borja
Lourenço, Anália
Margolles Barros, Abelardo
author_role author
author2 Ruíz García, Lorena
Tamés, Hector
Ruas-Madiedo, Patricia
Fdez-Riverola, Florentino
Sánchez García, Borja
Lourenço, Anália
Margolles Barros, Abelardo
author2_role author
author
author
author
author
author
author
dc.contributor.none.fl_str_mv Ministerio de Economía y Competitividad (España)
Ministerio de Ciencia, Innovación y Universidades (España)
Agencia Estatal de Investigación (España)
Principado de Asturias
Xunta de Galicia
European Commission
Fundação para a Ciência e a Tecnologia (Portugal)
Consejo Superior de Investigaciones Científicas [https://ror.org/02gfc7t72]
dc.subject.none.fl_str_mv Bifidobacterium
Longum
Infantis
Carbohydrates
Glycoside hydrolases
Computational screening
topic Bifidobacterium
Longum
Infantis
Carbohydrates
Glycoside hydrolases
Computational screening
description © 2020 by the authors.
publishDate 2020
dc.date.none.fl_str_mv 2020
2020
2020
2020
dc.type.none.fl_str_mv info:eu-repo/semantics/article
http://purl.org/coar/resource_type/c_6501
Publisher's version
info:eu-repo/semantics/publishedVersion
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status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/10261/212540
url http://hdl.handle.net/10261/212540
dc.language.none.fl_str_mv Inglés
language_invalid_str_mv Inglés
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info:eu-repo/grantAgreement/MINECO/Plan Estatal de Investigación Científica y Técnica y de Innovación 2013-2016/AGL2016-78311-R
info:eu-repo/grantAgreement/AEI/Plan Estatal de Investigación Científica y Técnica y de Innovación 2017-2020/RTI2018-095021-J-I00
RTI2018-095021-J-I00/AEI/10.13039/501100011033
https://doi.org/10.3390/microorganisms8050723
Sí
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.publisher.none.fl_str_mv Multidisciplinary Digital Publishing Institute
publisher.none.fl_str_mv Multidisciplinary Digital Publishing Institute
dc.source.none.fl_str_mv reponame:DIGITAL.CSIC. Repositorio Institucional del CSIC
instname:Consejo Superior de Investigaciones Científicas (CSIC)
instname_str Consejo Superior de Investigaciones Científicas (CSIC)
reponame_str DIGITAL.CSIC. Repositorio Institucional del CSIC
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spelling Revisiting the Metabolic Capabilities of Bifidobacterium longum susbp. longum and Bifidobacterium longum subsp. infantis from a Glycoside Hydrolase PerspectiveBlanco González, GuillermoRuíz García, LorenaTamés, HectorRuas-Madiedo, PatriciaFdez-Riverola, FlorentinoSánchez García, BorjaLourenço, AnáliaMargolles Barros, AbelardoBifidobacteriumLongumInfantisCarbohydratesGlycoside hydrolasesComputational screening© 2020 by the authors.Bifidobacteria are among the most abundant microorganisms inhabiting the intestine of humans and many animals. Within the genus Bifidobacterium, several beneficial effects have been attributed to strains belonging to the subspecies Bifidobacterium longum subsp. longum and Bifidobacterium longum subsp. infantis, which are often found in infants and adults. The increasing numbers of sequenced genomes belonging to these two subspecies, and the availability of novel computational tools focused on predicting glycolytic abilities, with the aim of understanding the capabilities of degrading specific carbohydrates, allowed us to depict the potential glycoside hydrolases (GH) of these bacteria, with a focus on those GH profiles that differ in the two subspecies. We performed an in silico examination of 188 sequenced B. longum genomes and depicted the commonly present and strain-specific GHs and GH families among representatives of this species. Additionally, GH profiling, genome-based and 16S rRNA-based clustering analyses showed that the subspecies assignment of some strains does not properly match with their genetic background. Furthermore, the analysis of the potential GH component allowed the distinction of clear GH patterns. Some of the GH activities, and their link with the two subspecies under study, are further discussed. Overall, our in silico analysis poses some questions about the suitability of considering the GH activities of B. longum subsp. longum and B. longum subsp. infantis to gain insight into the characterization and classification of these two subspecies with probiotic interest.The research included in the present work was funded by the grants AGL2016-78311-R (funded by AEI/FEDER, UE), RTI2018-095021-J-I00 (funded by MCIU/AEI/FEDER, UE), and IDI/2018/000236 (funded by PCTI Gobierno del Principado de Asturias/FEDER, UE). This study was supported by the Consellería de Educación, Universidades e Formación Profesional (Xunta de Galicia) under the scope of the strategic funding of ED431C2018/55-GRC Competitive Reference Group, the “Centro singular de investigación de Galicia” (accreditation 2019-2022) and the European Union (European Regional Development Fund—ERDF)-Ref. ED431G2019/06, and the Portuguese Foundation for Science and Technology (FCT) under the scope of the strategic funding of UIDB/04469/2020 unit and BioTecNorte operation (NORTE-01-0145-FEDER-000004) funded by the European Regional Development Fund under the scope of Norte2020—Programa Operacional Regional do Norte.Peer reviewedMultidisciplinary Digital Publishing InstituteMinisterio de Economía y Competitividad (España)Ministerio de Ciencia, Innovación y Universidades (España)Agencia Estatal de Investigación (España)Principado de AsturiasXunta de GaliciaEuropean CommissionFundação para a Ciência e a Tecnologia (Portugal)Consejo Superior de Investigaciones Científicas [https://ror.org/02gfc7t72]2020202020202020info:eu-repo/semantics/articlehttp://purl.org/coar/resource_type/c_6501Publisher's versioninfo:eu-repo/semantics/publishedVersionhttp://hdl.handle.net/10261/212540reponame:DIGITAL.CSIC. Repositorio Institucional del CSICinstname:Consejo Superior de Investigaciones Científicas (CSIC)Inglés#PLACEHOLDER_PARENT_METADATA_VALUE##PLACEHOLDER_PARENT_METADATA_VALUE##PLACEHOLDER_PARENT_METADATA_VALUE#info:eu-repo/grantAgreement/MINECO/Plan Estatal de Investigación Científica y Técnica y de Innovación 2013-2016/AGL2016-78311-Rinfo:eu-repo/grantAgreement/AEI/Plan Estatal de Investigación Científica y Técnica y de Innovación 2017-2020/RTI2018-095021-J-I00RTI2018-095021-J-I00/AEI/10.13039/501100011033https://doi.org/10.3390/microorganisms8050723Síinfo:eu-repo/semantics/openAccessoai:digital.csic.es:10261/2125402026-05-22T06:33:51Z
score 15.812429

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