Implication of Candida parapsilosis FKS1 and FKS2 mutations in reduced echinocandin susceptibility
We evaluated FKS1 and FKS2 mutations in Candida parapsilosis bloodstream isolates and correlated them with the echinocandin MIC values determined by guidelines in CLSI document M27-A3 and the YeastOne panel. All mutations detected were outside hot spot (HS) regions. The F1386S mutation detected in a...
| Autores: | , , , , |
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| Tipo de recurso: | artículo |
| Estado: | Versión publicada |
| Fecha de publicación: | 2015 |
| País: | España |
| Institución: | Institut d’Investigació Biomèdica Sant Pau (IIB Sant Pau) |
| Repositorio: | r-IIB SANT PAU. Repositorio Institucional de Producción Científica del Instituto de Investigación Biomédica Sant Pau |
| OAI Identifier: | oai:iibsantpau.fundanetsuite.com:p10613 |
| Acceso en línea: | https://iibsantpau.fundanetsuite.com/Publicaciones/ProdCientif/PublicacionFrw.aspx?id=10613 https://europepmc.org/articles/pmc4432215 |
| Access Level: | acceso abierto |
| Palabra clave: | anidulafungin caspofungin echinocandin micafungin antifungal agent fungal protein antifungal susceptibility Article Candida parapsilosis FKS1 gene FKS2 gene fungal gene genetic engineering IC50 minimum inhibitory concentration mutation nonhuman point mutation practice guideline priority journal Saccharomyces cerevisiae antifungal resistance Candida drug effects genetics Antifungal Agents Drug Resistance, Fungal Echinocandins Fungal Proteins Mutation |
| Sumario: | We evaluated FKS1 and FKS2 mutations in Candida parapsilosis bloodstream isolates and correlated them with the echinocandin MIC values determined by guidelines in CLSI document M27-A3 and the YeastOne panel. All mutations detected were outside hot spot (HS) regions. The F1386S mutation detected in an isolate that was resistant by the YeastOne panel but not by the M27-A3 guidelines might be implicated in echinocandin resistance. Further studies are needed to confirm the implication of the F1386S mutation and to elucidate the capability of the M27-A3 guidelines to detect echinocandin resistance. © Copyright 2015 American Society for Microbiology. All Rights Reserved. |
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