A forensic population database in El Salvador: 58 STRs and 94 SNPs

We have genotyped the 58 STRs (27 autosomal, 24 Y-STRs and 7 X-STRs) and 94 autosomal SNPs in Illumina ForenSeq™ Primer Mix A in a sample of 248 men and 143 women from El Salvador, Central America. Regional division (Centro, Oriente, Occidente) showed in almost all cases FST values not significantly...

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Detalhes bibliográficos
Autores: Casals López, Ferran, Rasal Soteras, Raquel, Anglada Busquets, Roger, Tormo, Marc, Bonet, Núria, Rivas, Nury, Vásquez, Patricia, Calafell i Majó, Francesc
Tipo de documento: artigo
Estado:Versión aceptada para publicación
Data de publicação:2021
País:España
Recursos:Universitat Pompeu Fabra
Repositório:Repositorio Digital de la UPF
OAI Identifier:oai:repositori.upf.edu:10230/52268
Acesso em linha:http://hdl.handle.net/10230/52268
http://dx.doi.org/10.1016/j.fsigen.2021.102646
Access Level:Acceso aberto
Palavra-chave:Massive parallel sequencing
Missing persons
Repeat sequence-based alleles
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spelling A forensic population database in El Salvador: 58 STRs and 94 SNPsCasals López, FerranRasal Soteras, RaquelAnglada Busquets, RogerTormo, MarcBonet, NúriaRivas, NuryVásquez, PatriciaCalafell i Majó, FrancescMassive parallel sequencingMissing personsRepeat sequence-based allelesWe have genotyped the 58 STRs (27 autosomal, 24 Y-STRs and 7 X-STRs) and 94 autosomal SNPs in Illumina ForenSeq™ Primer Mix A in a sample of 248 men and 143 women from El Salvador, Central America. Regional division (Centro, Oriente, Occidente) showed in almost all cases FST values not significantly different from 0, and further analyses were applied only to the undivided, country-wide population. The overall random match probability (RMP) decreased from 6.79 × 10-31 in length-based genotypes in the 27 autosomal STRs to 1.47 × 10-34 in repeat-sequence based genotypes. Combining the autosomal loci in this set, RMP reaches 2.97 × 10-70. In a population genetic analysis, El Salvador showed the lowest FST values with US Hispanics both for autosomal and X-STRs; however, it was much closer to Native Americans for the latter than for the former, in accordance with the well-known gender-biased admixture that created most Latin American populations.This work was supported by the Spanish Ministry of Economy and Competitiveness and Agencia Estatal de Investigación (grant numbers CGL2016–75389-P (MINEICO/FEDER, UE), PID2019–106485GB-I00/AEI/10.13039/501100011033 (MINEICO), and “Unidad María de Maeztu” (MDM-2014–0370) to FCal; Agència de Gestió d′Ajuts Universitaris i de la Recerca (Generalitat de Catalunya, grant 2017SGR00702); Agència Catalana de Cooperació al Desenvolupament (ACCD004/17/00019 and ACCD016/18/00031); Fundación Panamericana para el Desarrollo (PADF, No. PRDHD-RFA-R-2017–009). We thank also the Ministry of Health of El Salvador, which, in 2018, allowed us to take samples at their facilities.Elsevier20222021info:eu-repo/semantics/articleinfo:eu-repo/semantics/acceptedVersionapplication/pdfapplication/pdfhttp://hdl.handle.net/10230/52268http://dx.doi.org/10.1016/j.fsigen.2021.102646reponame:Repositorio Digital de la UPFinstname:Universitat Pompeu FabraInglésForensic Sci Int Genet. 2021;57:102646info:eu-repo/grantAgreement/ES/1PE/CGL2016-75389-Pinfo:eu-repo/grantAgreement/ES/2PE/PID2019-106485GB-I00© Elsevier http://dx.doi.org/10.1016/j.fsigen.2021.102646info:eu-repo/semantics/openAccessoai:repositori.upf.edu:10230/522682026-06-12T07:21:37Z
dc.title.none.fl_str_mv A forensic population database in El Salvador: 58 STRs and 94 SNPs
title A forensic population database in El Salvador: 58 STRs and 94 SNPs
spellingShingle A forensic population database in El Salvador: 58 STRs and 94 SNPs
Casals López, Ferran
Massive parallel sequencing
Missing persons
Repeat sequence-based alleles
title_short A forensic population database in El Salvador: 58 STRs and 94 SNPs
title_full A forensic population database in El Salvador: 58 STRs and 94 SNPs
title_fullStr A forensic population database in El Salvador: 58 STRs and 94 SNPs
title_full_unstemmed A forensic population database in El Salvador: 58 STRs and 94 SNPs
title_sort A forensic population database in El Salvador: 58 STRs and 94 SNPs
dc.creator.none.fl_str_mv Casals López, Ferran
Rasal Soteras, Raquel
Anglada Busquets, Roger
Tormo, Marc
Bonet, Núria
Rivas, Nury
Vásquez, Patricia
Calafell i Majó, Francesc
author Casals López, Ferran
author_facet Casals López, Ferran
Rasal Soteras, Raquel
Anglada Busquets, Roger
Tormo, Marc
Bonet, Núria
Rivas, Nury
Vásquez, Patricia
Calafell i Majó, Francesc
author_role author
author2 Rasal Soteras, Raquel
Anglada Busquets, Roger
Tormo, Marc
Bonet, Núria
Rivas, Nury
Vásquez, Patricia
Calafell i Majó, Francesc
author2_role author
author
author
author
author
author
author
dc.subject.none.fl_str_mv Massive parallel sequencing
Missing persons
Repeat sequence-based alleles
topic Massive parallel sequencing
Missing persons
Repeat sequence-based alleles
description We have genotyped the 58 STRs (27 autosomal, 24 Y-STRs and 7 X-STRs) and 94 autosomal SNPs in Illumina ForenSeq™ Primer Mix A in a sample of 248 men and 143 women from El Salvador, Central America. Regional division (Centro, Oriente, Occidente) showed in almost all cases FST values not significantly different from 0, and further analyses were applied only to the undivided, country-wide population. The overall random match probability (RMP) decreased from 6.79 × 10-31 in length-based genotypes in the 27 autosomal STRs to 1.47 × 10-34 in repeat-sequence based genotypes. Combining the autosomal loci in this set, RMP reaches 2.97 × 10-70. In a population genetic analysis, El Salvador showed the lowest FST values with US Hispanics both for autosomal and X-STRs; however, it was much closer to Native Americans for the latter than for the former, in accordance with the well-known gender-biased admixture that created most Latin American populations.
publishDate 2021
dc.date.none.fl_str_mv 2021
2022
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/acceptedVersion
format article
status_str acceptedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/10230/52268
http://dx.doi.org/10.1016/j.fsigen.2021.102646
url http://hdl.handle.net/10230/52268
http://dx.doi.org/10.1016/j.fsigen.2021.102646
dc.language.none.fl_str_mv Inglés
language_invalid_str_mv Inglés
dc.relation.none.fl_str_mv Forensic Sci Int Genet. 2021;57:102646
info:eu-repo/grantAgreement/ES/1PE/CGL2016-75389-P
info:eu-repo/grantAgreement/ES/2PE/PID2019-106485GB-I00
dc.rights.none.fl_str_mv © Elsevier http://dx.doi.org/10.1016/j.fsigen.2021.102646
info:eu-repo/semantics/openAccess
rights_invalid_str_mv © Elsevier http://dx.doi.org/10.1016/j.fsigen.2021.102646
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
application/pdf
dc.publisher.none.fl_str_mv Elsevier
publisher.none.fl_str_mv Elsevier
dc.source.none.fl_str_mv reponame:Repositorio Digital de la UPF
instname:Universitat Pompeu Fabra
instname_str Universitat Pompeu Fabra
reponame_str Repositorio Digital de la UPF
collection Repositorio Digital de la UPF
repository.name.fl_str_mv
repository.mail.fl_str_mv
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