Demographic and clinical profile of idiopathic pulmonary fibrosis patients in Spain
Little is known on the characteristics of patients diagnosed with idiopathic pulmonary fibrosis (IPF) in Spain. We aimed to characterize the demographic and clinical profile of IPF patients included in the IPF National Registry of the Spanish Respiratory Society (SEPAR). This is a prospective, obser...
| Autores: | , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , |
|---|---|
| Tipo de recurso: | artículo |
| Fecha de publicación: | 2019 |
| País: | España |
| Institución: | Universitat Autònoma de Barcelona |
| Repositorio: | Dipòsit Digital de Documents de la UAB |
| Idioma: | inglés |
| OAI Identifier: | oai:ddd.uab.cat:285821 |
| Acceso en línea: | https://ddd.uab.cat/record/285821 https://dx.doi.org/urn:doi:10.1186/s12931-019-1084-0 |
| Access Level: | acceso abierto |
| Palabra clave: | Anti-fibrotic treatment Idiopathic pulmonary fibrosis National registry SEPAR Spain |
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Demographic and clinical profile of idiopathic pulmonary fibrosis patients in SpainThe SEPAR National RegistryFernández-Fabrellas, EstrellaMolina Molina, Maria|||0000-0002-1852-1723Soriano, Joan B.|||0000-0001-9740-2994Rodríguez Portal, José AntonioAncochea, Julio|||0000-0001-7451-4133Valenzuela, Claudia|||0000-0002-0856-6290Xaubet, AntoniAburto, Myriam|||0000-0001-8644-1015Alfageme, Inmaculada|||0000-0002-5106-1669Bollo de Miguel, ElenaCano, EstebanCasanova Espinosa, ÁlvaroCastillo, Diego|||0000-0002-4862-3595Figuerola Mendal, J.A.García Sevila, Raquel|||0000-0002-4218-793XGaudó Navarro, Javier I.Gómez-Carrera, LuisSaez González, Jesus MiguelHerrera Lara, SusanaLaporta Hernández, RosalíaMarín González, M.Nieto Barbero, AsunciónPortillo, Karina|||0000-0002-7804-1051Romero, Ana DoloresSánchez Simón-Talero, RafaelaSancho Chust, José N.|||0000-0002-3028-0715Sellares, JacoboSoler-Sempere, Maria J.|||0000-0002-6607-2037Sauleda, Jaume|||0000-0002-9806-3370Tomás López, LauraVillanueva, Manuel Angel|||0000-0003-3256-9579Anti-fibrotic treatmentIdiopathic pulmonary fibrosisNational registrySEPARSpainLittle is known on the characteristics of patients diagnosed with idiopathic pulmonary fibrosis (IPF) in Spain. We aimed to characterize the demographic and clinical profile of IPF patients included in the IPF National Registry of the Spanish Respiratory Society (SEPAR). This is a prospective, observational, multicentre and nationwide study that involved 608 IPF patients included in the SEPAR IPF Registry up to June 27th, 2017, and who received any treatment for their disease. IPF patients were predominantly males, ex-smokers, and aged in their 70s, similar to other registries. Upon inclusion, mean ± SD predicted forced vital capacity was 77.6% ± 19.4, diffusing capacity for carbon monoxide was 48.5% ± 17.7, and the 6-min walk distance was 423.5 m ± 110.4. The diagnosis was mainly established on results from the high-resolution computed tomography in the proper clinical context (55.0% of patients), while 21.2% of patients required invasive procedures (surgical lung biopsy) for definitive diagnosis. Anti-fibrotic treatment was prescribed in 69.4% of cases, 51.5% pirfenidone and 17.9% nintedanib, overall with a good safety profile. The SEPAR IPF Registry should help to further characterize current characteristics and future trends of IPF patients in Spain and compare/pool them with other registries and cohorts.Universitat Autònoma de Barcelona 22019-01-0120192019-01-01Articlehttp://purl.org/coar/resource_type/c_6501VoRhttp://purl.org/coar/version/c_970fb48d4fbd8a85info:eu-repo/semantics/articleapplication/pdfhttps://ddd.uab.cat/record/285821https://dx.doi.org/urn:doi:10.1186/s12931-019-1084-0reponame:Dipòsit Digital de Documents de la UABinstname:Universitat Autònoma de BarcelonaInglésengopen accesshttp://purl.org/coar/access_right/c_abf2Aquest document està subjecte a una llicència d'ús Creative Commons. Es permet la reproducció total o parcial, la distribució, la comunicació pública de l'obra i la creació d'obres derivades, fins i tot amb finalitats comercials, sempre i quan es reconegui l'autoria de l'obra original.https://creativecommons.org/licenses/by/4.0/info:eu-repo/semantics/openAccessoai:ddd.uab.cat:2858212026-06-06T12:50:31Z |
| dc.title.none.fl_str_mv |
Demographic and clinical profile of idiopathic pulmonary fibrosis patients in Spain The SEPAR National Registry |
| title |
Demographic and clinical profile of idiopathic pulmonary fibrosis patients in Spain |
| spellingShingle |
Demographic and clinical profile of idiopathic pulmonary fibrosis patients in Spain Fernández-Fabrellas, Estrella Anti-fibrotic treatment Idiopathic pulmonary fibrosis National registry SEPAR Spain |
| title_short |
Demographic and clinical profile of idiopathic pulmonary fibrosis patients in Spain |
| title_full |
Demographic and clinical profile of idiopathic pulmonary fibrosis patients in Spain |
| title_fullStr |
Demographic and clinical profile of idiopathic pulmonary fibrosis patients in Spain |
| title_full_unstemmed |
Demographic and clinical profile of idiopathic pulmonary fibrosis patients in Spain |
| title_sort |
Demographic and clinical profile of idiopathic pulmonary fibrosis patients in Spain |
| dc.creator.none.fl_str_mv |
Fernández-Fabrellas, Estrella Molina Molina, Maria|||0000-0002-1852-1723 Soriano, Joan B.|||0000-0001-9740-2994 Rodríguez Portal, José Antonio Ancochea, Julio|||0000-0001-7451-4133 Valenzuela, Claudia|||0000-0002-0856-6290 Xaubet, Antoni Aburto, Myriam|||0000-0001-8644-1015 Alfageme, Inmaculada|||0000-0002-5106-1669 Bollo de Miguel, Elena Cano, Esteban Casanova Espinosa, Álvaro Castillo, Diego|||0000-0002-4862-3595 Figuerola Mendal, J.A. García Sevila, Raquel|||0000-0002-4218-793X Gaudó Navarro, Javier I. Gómez-Carrera, Luis Saez González, Jesus Miguel Herrera Lara, Susana Laporta Hernández, Rosalía Marín González, M. Nieto Barbero, Asunción Portillo, Karina|||0000-0002-7804-1051 Romero, Ana Dolores Sánchez Simón-Talero, Rafaela Sancho Chust, José N.|||0000-0002-3028-0715 Sellares, Jacobo Soler-Sempere, Maria J.|||0000-0002-6607-2037 Sauleda, Jaume|||0000-0002-9806-3370 Tomás López, Laura Villanueva, Manuel Angel|||0000-0003-3256-9579 |
| author |
Fernández-Fabrellas, Estrella |
| author_facet |
Fernández-Fabrellas, Estrella Molina Molina, Maria|||0000-0002-1852-1723 Soriano, Joan B.|||0000-0001-9740-2994 Rodríguez Portal, José Antonio Ancochea, Julio|||0000-0001-7451-4133 Valenzuela, Claudia|||0000-0002-0856-6290 Xaubet, Antoni Aburto, Myriam|||0000-0001-8644-1015 Alfageme, Inmaculada|||0000-0002-5106-1669 Bollo de Miguel, Elena Cano, Esteban Casanova Espinosa, Álvaro Castillo, Diego|||0000-0002-4862-3595 Figuerola Mendal, J.A. García Sevila, Raquel|||0000-0002-4218-793X Gaudó Navarro, Javier I. Gómez-Carrera, Luis Saez González, Jesus Miguel Herrera Lara, Susana Laporta Hernández, Rosalía Marín González, M. Nieto Barbero, Asunción Portillo, Karina|||0000-0002-7804-1051 Romero, Ana Dolores Sánchez Simón-Talero, Rafaela Sancho Chust, José N.|||0000-0002-3028-0715 Sellares, Jacobo Soler-Sempere, Maria J.|||0000-0002-6607-2037 Sauleda, Jaume|||0000-0002-9806-3370 Tomás López, Laura Villanueva, Manuel Angel|||0000-0003-3256-9579 |
| author_role |
author |
| author2 |
Molina Molina, Maria|||0000-0002-1852-1723 Soriano, Joan B.|||0000-0001-9740-2994 Rodríguez Portal, José Antonio Ancochea, Julio|||0000-0001-7451-4133 Valenzuela, Claudia|||0000-0002-0856-6290 Xaubet, Antoni Aburto, Myriam|||0000-0001-8644-1015 Alfageme, Inmaculada|||0000-0002-5106-1669 Bollo de Miguel, Elena Cano, Esteban Casanova Espinosa, Álvaro Castillo, Diego|||0000-0002-4862-3595 Figuerola Mendal, J.A. García Sevila, Raquel|||0000-0002-4218-793X Gaudó Navarro, Javier I. Gómez-Carrera, Luis Saez González, Jesus Miguel Herrera Lara, Susana Laporta Hernández, Rosalía Marín González, M. Nieto Barbero, Asunción Portillo, Karina|||0000-0002-7804-1051 Romero, Ana Dolores Sánchez Simón-Talero, Rafaela Sancho Chust, José N.|||0000-0002-3028-0715 Sellares, Jacobo Soler-Sempere, Maria J.|||0000-0002-6607-2037 Sauleda, Jaume|||0000-0002-9806-3370 Tomás López, Laura Villanueva, Manuel Angel|||0000-0003-3256-9579 |
| author2_role |
author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author |
| dc.contributor.none.fl_str_mv |
Universitat Autònoma de Barcelona |
| dc.subject.none.fl_str_mv |
Anti-fibrotic treatment Idiopathic pulmonary fibrosis National registry SEPAR Spain |
| topic |
Anti-fibrotic treatment Idiopathic pulmonary fibrosis National registry SEPAR Spain |
| description |
Little is known on the characteristics of patients diagnosed with idiopathic pulmonary fibrosis (IPF) in Spain. We aimed to characterize the demographic and clinical profile of IPF patients included in the IPF National Registry of the Spanish Respiratory Society (SEPAR). This is a prospective, observational, multicentre and nationwide study that involved 608 IPF patients included in the SEPAR IPF Registry up to June 27th, 2017, and who received any treatment for their disease. IPF patients were predominantly males, ex-smokers, and aged in their 70s, similar to other registries. Upon inclusion, mean ± SD predicted forced vital capacity was 77.6% ± 19.4, diffusing capacity for carbon monoxide was 48.5% ± 17.7, and the 6-min walk distance was 423.5 m ± 110.4. The diagnosis was mainly established on results from the high-resolution computed tomography in the proper clinical context (55.0% of patients), while 21.2% of patients required invasive procedures (surgical lung biopsy) for definitive diagnosis. Anti-fibrotic treatment was prescribed in 69.4% of cases, 51.5% pirfenidone and 17.9% nintedanib, overall with a good safety profile. The SEPAR IPF Registry should help to further characterize current characteristics and future trends of IPF patients in Spain and compare/pool them with other registries and cohorts. |
| publishDate |
2019 |
| dc.date.none.fl_str_mv |
2 2019-01-01 2019 2019-01-01 |
| dc.type.none.fl_str_mv |
Article http://purl.org/coar/resource_type/c_6501 VoR http://purl.org/coar/version/c_970fb48d4fbd8a85 |
| dc.type.openaire.fl_str_mv |
info:eu-repo/semantics/article |
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article |
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https://ddd.uab.cat/record/285821 https://dx.doi.org/urn:doi:10.1186/s12931-019-1084-0 |
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https://ddd.uab.cat/record/285821 https://dx.doi.org/urn:doi:10.1186/s12931-019-1084-0 |
| dc.language.none.fl_str_mv |
Inglés eng |
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Inglés |
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eng |
| dc.rights.none.fl_str_mv |
open access http://purl.org/coar/access_right/c_abf2 https://creativecommons.org/licenses/by/4.0/ |
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info:eu-repo/semantics/openAccess |
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open access http://purl.org/coar/access_right/c_abf2 https://creativecommons.org/licenses/by/4.0/ |
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openAccess |
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application/pdf |
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reponame:Dipòsit Digital de Documents de la UAB instname:Universitat Autònoma de Barcelona |
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Universitat Autònoma de Barcelona |
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