Revealing the specificity of human H1 influenza A viruses to complex N-glycans

11 p.-5 fig.-1 schem.-1 graph. abst.

Detalles Bibliográficos
Autores: Canales, Ángeles, Sastre, Javier, Orduña, José M., Spruit, Cindy M., Pérez-Castells, Javier, Domínguez, Gema, Bouwman, Kim M., Van der Woude, Roosmarijn, Cañada, F. Javier, Nycholat, Corwin M., Paulson, James C., Boons, Geert-Jan, Jiménez-Barbero, Jesús, De Vries, Robert P.
Tipo de recurso: artículo
Estado:Versión publicada
Fecha de publicación:2023
País:España
Institución:Consejo Superior de Investigaciones Científicas (CSIC)
Repositorio:DIGITAL.CSIC. Repositorio Institucional del CSIC
OAI Identifier:oai:digital.csic.es:10261/296859
Acceso en línea:http://hdl.handle.net/10261/296859
Access Level:acceso abierto
Palabra clave:Influenza virus
N-glycan
Recognition
Glycan array
NMR
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network_name_str España
repository_id_str
dc.title.none.fl_str_mv Revealing the specificity of human H1 influenza A viruses to complex N-glycans
title Revealing the specificity of human H1 influenza A viruses to complex N-glycans
spellingShingle Revealing the specificity of human H1 influenza A viruses to complex N-glycans
Canales, Ángeles
Influenza virus
N-glycan
Recognition
Glycan array
NMR
title_short Revealing the specificity of human H1 influenza A viruses to complex N-glycans
title_full Revealing the specificity of human H1 influenza A viruses to complex N-glycans
title_fullStr Revealing the specificity of human H1 influenza A viruses to complex N-glycans
title_full_unstemmed Revealing the specificity of human H1 influenza A viruses to complex N-glycans
title_sort Revealing the specificity of human H1 influenza A viruses to complex N-glycans
dc.creator.none.fl_str_mv Canales, Ángeles
Sastre, Javier
Orduña, José M.
Spruit, Cindy M.
Pérez-Castells, Javier
Domínguez, Gema
Bouwman, Kim M.
Van der Woude, Roosmarijn
Cañada, F. Javier
Nycholat, Corwin M.
Paulson, James C.
Boons, Geert-Jan
Jiménez-Barbero, Jesús
De Vries, Robert P.
author Canales, Ángeles
author_facet Canales, Ángeles
Sastre, Javier
Orduña, José M.
Spruit, Cindy M.
Pérez-Castells, Javier
Domínguez, Gema
Bouwman, Kim M.
Van der Woude, Roosmarijn
Cañada, F. Javier
Nycholat, Corwin M.
Paulson, James C.
Boons, Geert-Jan
Jiménez-Barbero, Jesús
De Vries, Robert P.
author_role author
author2 Sastre, Javier
Orduña, José M.
Spruit, Cindy M.
Pérez-Castells, Javier
Domínguez, Gema
Bouwman, Kim M.
Van der Woude, Roosmarijn
Cañada, F. Javier
Nycholat, Corwin M.
Paulson, James C.
Boons, Geert-Jan
Jiménez-Barbero, Jesús
De Vries, Robert P.
author2_role author
author
author
author
author
author
author
author
author
author
author
author
author
dc.contributor.none.fl_str_mv European Commission
Royal Netherlands Academy of Arts and Sciences
Netherlands Organization for Scientific Research
Ministerio de Ciencia e Innovación (España)
Agencia Estatal de Investigación (España)
Instituto de Salud Carlos III
Canales, A. [0000-0003-0542-3080]
Sastre, Javier [0000-0002-1217-1558]
Orduña, José M. [0000-0003-4955-4998]
Spruit, Cindy M. [0000-0001-6570-7910]
Pérez-Castells, Javier [0000-0002-7256-0723]
Domínguez, Gema [0000-0001-7204-0341]
Bouwman, Kim M. [0000-0003-1794-6735]
Van der Woude, Roosmarijn [0000-0003-2151-5604]
Cañada, F. Javier [0000-0003-4462-1469]
Nycholat, Corwin M. [0000-0001-5943-5357]
Paulson, James C. [0000-0003-4589-5322]
Boons, Geert-Jan [0000-0003-3111-5954]
Jiménez-Barbero, Jesús [0000-0001-5421-8513]
De Vries, Robert P. [0000-0002-1586-4464]
Consejo Superior de Investigaciones Científicas [https://ror.org/02gfc7t72]
dc.subject.none.fl_str_mv Influenza virus
N-glycan
Recognition
Glycan array
NMR
topic Influenza virus
N-glycan
Recognition
Glycan array
NMR
description 11 p.-5 fig.-1 schem.-1 graph. abst.
publishDate 2023
dc.date.none.fl_str_mv 2023
2023
2023
dc.type.none.fl_str_mv info:eu-repo/semantics/article
http://purl.org/coar/resource_type/c_6501
Publisher's version
info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/10261/296859
url http://hdl.handle.net/10261/296859
dc.language.none.fl_str_mv Inglés
language_invalid_str_mv Inglés
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info:eu-repo/grantAgreement/EC/H2020/802780
info:eu-repo/grantAgreement/AEI/Plan Estatal de Investigación Científica y Técnica y de Innovación 2017-2020/PID2019-105237GB-I00
info:eu-repo/grantAgreement/AEI/Plan Estatal de Investigación Científica y Técnica y de Innovación 2017-2020/RTI2018-095588-B-I00
info:eu-repo/grantAgreement/EC/H2020/788143
info:eu-repo/grantAgreement/AEI/Plan Estatal de Investigación Científica y Técnica y de Innovación 2017-2020/RTI2018-094751-B-C21
info:eu-repo/grantAgreement/AEI/Plan Estatal de Investigación Científica y Técnica y de Innovación 2017-2020/RTI2018-094751-B-C22
https://doi.org/10.1021/jacsau.2c00664
Sí
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.publisher.none.fl_str_mv American Chemical Society
publisher.none.fl_str_mv American Chemical Society
dc.source.none.fl_str_mv reponame:DIGITAL.CSIC. Repositorio Institucional del CSIC
instname:Consejo Superior de Investigaciones Científicas (CSIC)
instname_str Consejo Superior de Investigaciones Científicas (CSIC)
reponame_str DIGITAL.CSIC. Repositorio Institucional del CSIC
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spelling Revealing the specificity of human H1 influenza A viruses to complex N-glycansCanales, ÁngelesSastre, JavierOrduña, José M.Spruit, Cindy M.Pérez-Castells, JavierDomínguez, GemaBouwman, Kim M.Van der Woude, RoosmarijnCañada, F. JavierNycholat, Corwin M.Paulson, James C.Boons, Geert-JanJiménez-Barbero, JesúsDe Vries, Robert P.Influenza virusN-glycanRecognitionGlycan arrayNMR11 p.-5 fig.-1 schem.-1 graph. abst.Influenza virus infection remains a threat to human health since viral hemagglutinins are constantly drifting, escaping infection and vaccine-induced antibody responses. Viral hemagglutinins from different viruses display variability in glycan recognition. In this context, recent H3N2 viruses have specificity for α2,6 sialylated branched N-glycans with at least three N-acetyllactosamine units (tri-LacNAc). In this work, we combined glycan arrays and tissue binding analyses with nuclear magnetic resonance experiments to characterize the glycan specificity of a family of H1 variants, including the one responsible for the 2009 pandemic outbreak. We also analyzed one engineered H6N1 mutant to understand if the preference for tri-LacNAc motifs could be a general trend in human-type receptor-adapted viruses. In addition, we developed a new NMR approach to perform competition experiments between glycans with similar compositions and different lengths. Our results point out that pandemic H1 viruses differ from previous seasonal H1 viruses by a strict preference for a minimum of di-LacNAc structural motifs.R.P.d.V. is a recipient of an ERC Starting grant from the European Commission (802780) and a Beijerinck Premium of the Royal Dutch Academy of Sciences. The glycan array setup was supported by the Netherlands Organization for Scientific Research (NWO, TOP-PUNT 718.015.003 to G.-J.P.H.B.). Dr. Lin Liu (CCRC) and Dr. Margreet A. Wolfert (Utrecht University) developed, printed, and validated the glycan microarray. We would like to thank Nikoloz Nemanichvili for technical assistance. A.C. acknowledges funding from Agencia Estatal de Investigación “Spanish Ministry of Science and Innovation” (MICINN) project PID2019-105237GB-I00. J.P.C. acknowledges funding by the Spanish MICINN, grant no. RTI2018-095588-B-I00 (co-funded by the European Regional Development Fund/European Social Fund, “Investing in your future”). JJB also thanks funding by the European Research Council (RECGLYCANMR, Advanced grant no. 788143), the Agencia Estatal de Investigación (Spain) for grants RTI2018-094751-B-C21 and C22 and PDI2021-1237810B–C21 and C22, and CIBERES, an initiative of the Instituto de Salud Carlos III (ISCIII), Madrid, Spain.Peer reviewedAmerican Chemical SocietyEuropean CommissionRoyal Netherlands Academy of Arts and SciencesNetherlands Organization for Scientific ResearchMinisterio de Ciencia e Innovación (España)Agencia Estatal de Investigación (España)Instituto de Salud Carlos IIICanales, A. [0000-0003-0542-3080]Sastre, Javier [0000-0002-1217-1558]Orduña, José M. [0000-0003-4955-4998]Spruit, Cindy M. [0000-0001-6570-7910]Pérez-Castells, Javier [0000-0002-7256-0723]Domínguez, Gema [0000-0001-7204-0341]Bouwman, Kim M. [0000-0003-1794-6735]Van der Woude, Roosmarijn [0000-0003-2151-5604]Cañada, F. Javier [0000-0003-4462-1469]Nycholat, Corwin M. [0000-0001-5943-5357]Paulson, James C. [0000-0003-4589-5322]Boons, Geert-Jan [0000-0003-3111-5954]Jiménez-Barbero, Jesús [0000-0001-5421-8513]De Vries, Robert P. [0000-0002-1586-4464]Consejo Superior de Investigaciones Científicas [https://ror.org/02gfc7t72]202320232023info:eu-repo/semantics/articlehttp://purl.org/coar/resource_type/c_6501Publisher's versioninfo:eu-repo/semantics/publishedVersionhttp://hdl.handle.net/10261/296859reponame:DIGITAL.CSIC. Repositorio Institucional del CSICinstname:Consejo Superior de Investigaciones Científicas (CSIC)Inglés#PLACEHOLDER_PARENT_METADATA_VALUE##PLACEHOLDER_PARENT_METADATA_VALUE##PLACEHOLDER_PARENT_METADATA_VALUE##PLACEHOLDER_PARENT_METADATA_VALUE##PLACEHOLDER_PARENT_METADATA_VALUE##PLACEHOLDER_PARENT_METADATA_VALUE#info:eu-repo/grantAgreement/EC/H2020/802780info:eu-repo/grantAgreement/AEI/Plan Estatal de Investigación Científica y Técnica y de Innovación 2017-2020/PID2019-105237GB-I00info:eu-repo/grantAgreement/AEI/Plan Estatal de Investigación Científica y Técnica y de Innovación 2017-2020/RTI2018-095588-B-I00info:eu-repo/grantAgreement/EC/H2020/788143info:eu-repo/grantAgreement/AEI/Plan Estatal de Investigación Científica y Técnica y de Innovación 2017-2020/RTI2018-094751-B-C21info:eu-repo/grantAgreement/AEI/Plan Estatal de Investigación Científica y Técnica y de Innovación 2017-2020/RTI2018-094751-B-C22https://doi.org/10.1021/jacsau.2c00664Síinfo:eu-repo/semantics/openAccessoai:digital.csic.es:10261/2968592026-05-22T06:33:51Z
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