Impact of maternal Bifidobacterium breve M-16V and scGOS/lcFOS supplementation during pregnancy and lactation on the maternal immune system and milk composition

Maternal synbiotic supplementation during pregnancy and lactation can significantly influence the immune system. Prebiotics and probiotics have a positive impact on the immune system by preventing or ameliorating among others intestinal disorders. This study focused on the immunomodulatory effects o...

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Autores: Sáez Fuertes, Laura, Kapravelou, Garyfallia, Grases Pintó, Blanca, Massot Cladera, Malen, Bernabeu Lorenzo, Manuel, Knipping, K., Garssen, J., Bourdet-Sicard, Raphaëlle, Castell, Margarida, Rodríguez Lagunas, María José, Collado, Maria Carmen, Pérez-Cano, Francisco J.
Tipo de recurso: artículo
Estado:Versión publicada
Fecha de publicación:2024
País:España
Institución:Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)
Repositorio:Recercat. Dipósit de la Recerca de Catalunya
OAI Identifier:oai:recercat.cat:2445/221904
Acceso en línea:https://hdl.handle.net/2445/221904
Access Level:acceso abierto
Palabra clave:Embaràs
Probiòtics
Alletament
Pregnancy
Probiotics
Breastfeeding
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spelling Impact of maternal Bifidobacterium breve M-16V and scGOS/lcFOS supplementation during pregnancy and lactation on the maternal immune system and milk compositionSáez Fuertes, LauraKapravelou, GaryfalliaGrases Pintó, BlancaMassot Cladera, MalenBernabeu Lorenzo, ManuelKnipping, K.Garssen, J.Bourdet-Sicard, RaphaëlleCastell, MargaridaRodríguez Lagunas, María JoséCollado, Maria CarmenPérez-Cano, Francisco J.EmbaràsProbiòticsAlletamentPregnancyProbioticsBreastfeedingMaternal synbiotic supplementation during pregnancy and lactation can significantly influence the immune system. Prebiotics and probiotics have a positive impact on the immune system by preventing or ameliorating among others intestinal disorders. This study focused on the immunomodulatory effects of B. breve M-16V and short chain galacto-oligosaccharides (scGOS)/long chain fructo-oligosachairdes (lcFOS), including systemic and mucosal compartments and milk composition. Methods: Lewis rats were orally administered with the synbiotic or vehicle during pregnancy (21 days) and lactation (21 days). At the weaning day, small intestine (SI), mammary gland (MG), adipose tissue, milk, mesenteric lymph nodes (MLN), salivary gland (SG), feces and cecal content were collected from the mothers. Results: The immunoglobulinome profile showed increased IgG2c in plasma and milk, as well as elevated sIgA in feces at weaning. The supplementation improved lipid metabolism through enhanced brown adipose tissue activity and reinforced the intestinal barrier by increasing the expression of Muc3, Cldn4, and Ocln. The higher production of short chain fatty acids in the cecum and increased Bifidobacterium counts suggest a potential positive impact on the gastrointestinal tract. Discussion: These findings indicate that maternal synbiotic supplementation during gestation and lactation improves their immunological status and improved milk composition. Keywords: Bifidobacterium breve M-16V; breastfeeding; long chain fructo-oligosachairdes (lcFOS); pregnancy; short chain galacto-oligosaccharides (scGOS).Frontiers Media2025202520242025info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersion19 p.application/pdfapplication/pdfhttps://hdl.handle.net/2445/221904Articles publicats en revistes (Bioquímica i Fisiologia)reponame:Recercat. Dipósit de la Recerca de Catalunyainstname:Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)InglésReproducció del document publicat a: https://doi.org/10.3389/fimmu.2024.1418594Frontiers in Immunology, 2024, vol. 15https://doi.org/10.3389/fimmu.2024.1418594cc-by (c) Sáez-Fuertes, L. et al., 2024http://creativecommons.org/licenses/by/4.0/info:eu-repo/semantics/openAccessoai:recercat.cat:2445/2219042026-05-29T05:05:01Z
dc.title.none.fl_str_mv Impact of maternal Bifidobacterium breve M-16V and scGOS/lcFOS supplementation during pregnancy and lactation on the maternal immune system and milk composition
title Impact of maternal Bifidobacterium breve M-16V and scGOS/lcFOS supplementation during pregnancy and lactation on the maternal immune system and milk composition
spellingShingle Impact of maternal Bifidobacterium breve M-16V and scGOS/lcFOS supplementation during pregnancy and lactation on the maternal immune system and milk composition
Sáez Fuertes, Laura
Embaràs
Probiòtics
Alletament
Pregnancy
Probiotics
Breastfeeding
title_short Impact of maternal Bifidobacterium breve M-16V and scGOS/lcFOS supplementation during pregnancy and lactation on the maternal immune system and milk composition
title_full Impact of maternal Bifidobacterium breve M-16V and scGOS/lcFOS supplementation during pregnancy and lactation on the maternal immune system and milk composition
title_fullStr Impact of maternal Bifidobacterium breve M-16V and scGOS/lcFOS supplementation during pregnancy and lactation on the maternal immune system and milk composition
title_full_unstemmed Impact of maternal Bifidobacterium breve M-16V and scGOS/lcFOS supplementation during pregnancy and lactation on the maternal immune system and milk composition
title_sort Impact of maternal Bifidobacterium breve M-16V and scGOS/lcFOS supplementation during pregnancy and lactation on the maternal immune system and milk composition
dc.creator.none.fl_str_mv Sáez Fuertes, Laura
Kapravelou, Garyfallia
Grases Pintó, Blanca
Massot Cladera, Malen
Bernabeu Lorenzo, Manuel
Knipping, K.
Garssen, J.
Bourdet-Sicard, Raphaëlle
Castell, Margarida
Rodríguez Lagunas, María José
Collado, Maria Carmen
Pérez-Cano, Francisco J.
author Sáez Fuertes, Laura
author_facet Sáez Fuertes, Laura
Kapravelou, Garyfallia
Grases Pintó, Blanca
Massot Cladera, Malen
Bernabeu Lorenzo, Manuel
Knipping, K.
Garssen, J.
Bourdet-Sicard, Raphaëlle
Castell, Margarida
Rodríguez Lagunas, María José
Collado, Maria Carmen
Pérez-Cano, Francisco J.
author_role author
author2 Kapravelou, Garyfallia
Grases Pintó, Blanca
Massot Cladera, Malen
Bernabeu Lorenzo, Manuel
Knipping, K.
Garssen, J.
Bourdet-Sicard, Raphaëlle
Castell, Margarida
Rodríguez Lagunas, María José
Collado, Maria Carmen
Pérez-Cano, Francisco J.
author2_role author
author
author
author
author
author
author
author
author
author
author
dc.subject.none.fl_str_mv Embaràs
Probiòtics
Alletament
Pregnancy
Probiotics
Breastfeeding
topic Embaràs
Probiòtics
Alletament
Pregnancy
Probiotics
Breastfeeding
description Maternal synbiotic supplementation during pregnancy and lactation can significantly influence the immune system. Prebiotics and probiotics have a positive impact on the immune system by preventing or ameliorating among others intestinal disorders. This study focused on the immunomodulatory effects of B. breve M-16V and short chain galacto-oligosaccharides (scGOS)/long chain fructo-oligosachairdes (lcFOS), including systemic and mucosal compartments and milk composition. Methods: Lewis rats were orally administered with the synbiotic or vehicle during pregnancy (21 days) and lactation (21 days). At the weaning day, small intestine (SI), mammary gland (MG), adipose tissue, milk, mesenteric lymph nodes (MLN), salivary gland (SG), feces and cecal content were collected from the mothers. Results: The immunoglobulinome profile showed increased IgG2c in plasma and milk, as well as elevated sIgA in feces at weaning. The supplementation improved lipid metabolism through enhanced brown adipose tissue activity and reinforced the intestinal barrier by increasing the expression of Muc3, Cldn4, and Ocln. The higher production of short chain fatty acids in the cecum and increased Bifidobacterium counts suggest a potential positive impact on the gastrointestinal tract. Discussion: These findings indicate that maternal synbiotic supplementation during gestation and lactation improves their immunological status and improved milk composition. Keywords: Bifidobacterium breve M-16V; breastfeeding; long chain fructo-oligosachairdes (lcFOS); pregnancy; short chain galacto-oligosaccharides (scGOS).
publishDate 2024
dc.date.none.fl_str_mv 2024
2025
2025
2025
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv https://hdl.handle.net/2445/221904
url https://hdl.handle.net/2445/221904
dc.language.none.fl_str_mv Inglés
language_invalid_str_mv Inglés
dc.relation.none.fl_str_mv Reproducció del document publicat a: https://doi.org/10.3389/fimmu.2024.1418594
Frontiers in Immunology, 2024, vol. 15
https://doi.org/10.3389/fimmu.2024.1418594
dc.rights.none.fl_str_mv cc-by (c) Sáez-Fuertes, L. et al., 2024
http://creativecommons.org/licenses/by/4.0/
info:eu-repo/semantics/openAccess
rights_invalid_str_mv cc-by (c) Sáez-Fuertes, L. et al., 2024
http://creativecommons.org/licenses/by/4.0/
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv 19 p.
application/pdf
application/pdf
dc.publisher.none.fl_str_mv Frontiers Media
publisher.none.fl_str_mv Frontiers Media
dc.source.none.fl_str_mv Articles publicats en revistes (Bioquímica i Fisiologia)
reponame:Recercat. Dipósit de la Recerca de Catalunya
instname:Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)
instname_str Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)
reponame_str Recercat. Dipósit de la Recerca de Catalunya
collection Recercat. Dipósit de la Recerca de Catalunya
repository.name.fl_str_mv
repository.mail.fl_str_mv
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score 15,811543

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