Analysis of histology-agnostic targets among soft tissue and bone sarcomas in the AACR GENIE database

Precision medicine; Sarcoma; Tissue-agnostic biomarker

Detalhes bibliográficos
Autores: Carmagnani Pestana, Roberto, Serrano Garcia, César
Formato: artículo
Estado:Versión publicada
Fecha de publicación:2023
País:España
Recursos:Departament de Salut de la Generalitat de Catalunya (DS)
Repositorio:Scientia. Dipòsit d'Informació Digital del Departament de Salut
OAI Identifier:oai:scientiasalut.gencat.cat:11351/9128
Acesso em linha:https://hdl.handle.net/11351/9128
Access Level:acceso abierto
Palavra-chave:Tumors de parts toves - Tractament
Marcadors tumorals
DISEASES::Neoplasms::Neoplasms by Site::Soft Tissue Neoplasms
Other subheadings::Other subheadings::Other subheadings::/drug therapy
CHEMICALS AND DRUGS::Biological Factors::Biomarkers::Biomarkers, Tumor
ENFERMEDADES::neoplasias::neoplasias por localización::neoplasias de los tejidos blandos
Otros calificadores::Otros calificadores::Otros calificadores::/farmacoterapia
COMPUESTOS QUÍMICOS Y DROGAS::factores biológicos::biomarcadores::marcadores tumorales
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network_acronym_str ES
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repository_id_str
spelling Analysis of histology-agnostic targets among soft tissue and bone sarcomas in the AACR GENIE databaseCarmagnani Pestana, RobertoSerrano Garcia, CésarTumors de parts toves - TractamentMarcadors tumoralsDISEASES::Neoplasms::Neoplasms by Site::Soft Tissue NeoplasmsOther subheadings::Other subheadings::Other subheadings::/drug therapyCHEMICALS AND DRUGS::Biological Factors::Biomarkers::Biomarkers, TumorENFERMEDADES::neoplasias::neoplasias por localización::neoplasias de los tejidos blandosOtros calificadores::Otros calificadores::Otros calificadores::/farmacoterapiaCOMPUESTOS QUÍMICOS Y DROGAS::factores biológicos::biomarcadores::marcadores tumoralesPrecision medicine; Sarcoma; Tissue-agnostic biomarkerMedicina de precisió; Sarcoma; Biomarcador agnòstic dels teixitsMedicina de precisión; Sarcoma; Biomarcador agnóstico de tejidoBackground: The development of novel therapies for patients with sarcoma is challenging due to the rarity and diversity of these mesenchymal neoplasms. Hence, histology-agnostic approvals can be of particular interest for the treatment of patients with soft tissue and bone sarcoma. Methods: We queried the American Association for Cancer Research (AACR) Project Genomics Evidence Neoplasia Information Exchange (GENIE) database Cohort v12.0-Public to investigate the prevalence of currently Food and Drug Administration (FDA)-approved and other potentially actionable histology-agnostic alterations in patients with soft tissue and bone sarcoma. Targets were identified by a literature review by the authors. Results are presented for each cohort identified in the GENIE database, namely: (1) soft tissue sarcoma (STS), (2) gastrointestinal stromal tumor (GIST), (3) bone sarcoma, (4) uterine sarcoma, and (5) breast sarcoma. Results: We identified 7,512 samples of 6,955 patients with sarcoma in the AAACR GENIE database v12.0-Public. Molecular alterations that could lead to the clinical use of a currently approved histology-agnostic therapy were identified in 2.1% of sarcomas (2.6% STS, 1.3% GIST, 1.4% bone, 2.7% uterine, and 0% breast). In addition, 2.9% of patients could be eligible for future histology-agnostic approvals. These specific mutations, fusions, and amplifications occurred in multiple histotypes in all cohorts. Discussion: Exploring a public large-scale genomic database, we identified that 5% of patients with sarcoma could be eligible for current histology-agnostic FDA-approved drugs or future potential histology-agnostic indications. These actionable alterations were present in a wide variety of histologies in soft tissue and bone sarcomas, highlighting that next-generation sequencing can be considered for patients with advanced sarcoma to guide treatment strategies.Frontiers MediaInstitut Català de la Salut[Pestana RC] Hospital Israelita Albert Einstein, São Paulo, Brazil. [Serrano C] Servei d’Oncologia Mèdica, Vall d’Hebron Hospital Universitari, Barcelona, Spain. Sarcoma Translational Research Program, Vall d’Hebron Institute of Oncology (VHIO), Barcelona, Spain. Vall d’Hebron Hospital Universitari, Barcelona, SpainVall d'Hebron Barcelona Hospital Campus202320232023info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionapplication/pdfhttps://hdl.handle.net/11351/9128Scientiareponame:Scientia. Dipòsit d'Informació Digital del Departament de Salutinstname:Departament de Salut de la Generalitat de Catalunya (DS)InglésFrontiers in Oncology;12https://doi.org/10.3389/fonc.2022.1079909Attribution 4.0 Internationalhttp://creativecommons.org/licenses/by/4.0/info:eu-repo/semantics/openAccessoai:scientiasalut.gencat.cat:11351/91282026-06-12T09:38:37Z
dc.title.none.fl_str_mv Analysis of histology-agnostic targets among soft tissue and bone sarcomas in the AACR GENIE database
title Analysis of histology-agnostic targets among soft tissue and bone sarcomas in the AACR GENIE database
spellingShingle Analysis of histology-agnostic targets among soft tissue and bone sarcomas in the AACR GENIE database
Carmagnani Pestana, Roberto
Tumors de parts toves - Tractament
Marcadors tumorals
DISEASES::Neoplasms::Neoplasms by Site::Soft Tissue Neoplasms
Other subheadings::Other subheadings::Other subheadings::/drug therapy
CHEMICALS AND DRUGS::Biological Factors::Biomarkers::Biomarkers, Tumor
ENFERMEDADES::neoplasias::neoplasias por localización::neoplasias de los tejidos blandos
Otros calificadores::Otros calificadores::Otros calificadores::/farmacoterapia
COMPUESTOS QUÍMICOS Y DROGAS::factores biológicos::biomarcadores::marcadores tumorales
title_short Analysis of histology-agnostic targets among soft tissue and bone sarcomas in the AACR GENIE database
title_full Analysis of histology-agnostic targets among soft tissue and bone sarcomas in the AACR GENIE database
title_fullStr Analysis of histology-agnostic targets among soft tissue and bone sarcomas in the AACR GENIE database
title_full_unstemmed Analysis of histology-agnostic targets among soft tissue and bone sarcomas in the AACR GENIE database
title_sort Analysis of histology-agnostic targets among soft tissue and bone sarcomas in the AACR GENIE database
dc.creator.none.fl_str_mv Carmagnani Pestana, Roberto
Serrano Garcia, César
author Carmagnani Pestana, Roberto
author_facet Carmagnani Pestana, Roberto
Serrano Garcia, César
author_role author
author2 Serrano Garcia, César
author2_role author
dc.contributor.none.fl_str_mv Institut Català de la Salut
[Pestana RC] Hospital Israelita Albert Einstein, São Paulo, Brazil. [Serrano C] Servei d’Oncologia Mèdica, Vall d’Hebron Hospital Universitari, Barcelona, Spain. Sarcoma Translational Research Program, Vall d’Hebron Institute of Oncology (VHIO), Barcelona, Spain. Vall d’Hebron Hospital Universitari, Barcelona, Spain
Vall d'Hebron Barcelona Hospital Campus
dc.subject.none.fl_str_mv Tumors de parts toves - Tractament
Marcadors tumorals
DISEASES::Neoplasms::Neoplasms by Site::Soft Tissue Neoplasms
Other subheadings::Other subheadings::Other subheadings::/drug therapy
CHEMICALS AND DRUGS::Biological Factors::Biomarkers::Biomarkers, Tumor
ENFERMEDADES::neoplasias::neoplasias por localización::neoplasias de los tejidos blandos
Otros calificadores::Otros calificadores::Otros calificadores::/farmacoterapia
COMPUESTOS QUÍMICOS Y DROGAS::factores biológicos::biomarcadores::marcadores tumorales
topic Tumors de parts toves - Tractament
Marcadors tumorals
DISEASES::Neoplasms::Neoplasms by Site::Soft Tissue Neoplasms
Other subheadings::Other subheadings::Other subheadings::/drug therapy
CHEMICALS AND DRUGS::Biological Factors::Biomarkers::Biomarkers, Tumor
ENFERMEDADES::neoplasias::neoplasias por localización::neoplasias de los tejidos blandos
Otros calificadores::Otros calificadores::Otros calificadores::/farmacoterapia
COMPUESTOS QUÍMICOS Y DROGAS::factores biológicos::biomarcadores::marcadores tumorales
description Precision medicine; Sarcoma; Tissue-agnostic biomarker
publishDate 2023
dc.date.none.fl_str_mv 2023
2023
2023
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv https://hdl.handle.net/11351/9128
url https://hdl.handle.net/11351/9128
dc.language.none.fl_str_mv Inglés
language_invalid_str_mv Inglés
dc.relation.none.fl_str_mv Frontiers in Oncology;12
https://doi.org/10.3389/fonc.2022.1079909
dc.rights.none.fl_str_mv Attribution 4.0 International
http://creativecommons.org/licenses/by/4.0/
info:eu-repo/semantics/openAccess
rights_invalid_str_mv Attribution 4.0 International
http://creativecommons.org/licenses/by/4.0/
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv Frontiers Media
publisher.none.fl_str_mv Frontiers Media
dc.source.none.fl_str_mv Scientia
reponame:Scientia. Dipòsit d'Informació Digital del Departament de Salut
instname:Departament de Salut de la Generalitat de Catalunya (DS)
instname_str Departament de Salut de la Generalitat de Catalunya (DS)
reponame_str Scientia. Dipòsit d'Informació Digital del Departament de Salut
collection Scientia. Dipòsit d'Informació Digital del Departament de Salut
repository.name.fl_str_mv
repository.mail.fl_str_mv
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score 15.811543

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