Hypersensitivity reactions to non-steroidal anti-inflammatory drugs and tolerance to alternative drugs

Introduction: Hypersensitivity reactions to non-steroidal anti-inflammatory drugs (NSAIDs) are the most common reactions to drugs. The prevalence varies from 0.6 to 5.7% in general population, but there are no data available in children. The aim of this study is to determine the frequency of patient...

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Autores: Calvo Campoverde K, Giner-Muñoz MT, Martínez Valdez L, Rojas Volquez M, Lozano Blasco J, Machinena A, Plaza AM
Tipo de documento: artigo
Estado:Versão publicada
Data de publicação:2016
País:España
Recursos:Fundació Sant Joan de Déu
Repositório:r-FSJD. Repositorio Institucional de Producción Científica de la Fundació Sant Joan de Déu
OAI Identifier:oai:fsjd.fundanetsuite.com:p12504
Acesso em linha:https://fsjd.fundanetsuite.com/Publicaciones/ProdCientif/PublicacionFrw.aspx?id=12504
Access Level:Acceso aberto
Palavra-chave:Hypersensitivity to non-steroidal anti-inflammatory drugs
Alternative drugs
Selective hypersensitivity
Multiple hypersensitivity
Drug provocation test
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spelling Hypersensitivity reactions to non-steroidal anti-inflammatory drugs and tolerance to alternative drugsCalvo Campoverde KGiner-Muñoz MTMartínez Valdez LRojas Volquez MLozano Blasco JMachinena APlaza AMHypersensitivity to non-steroidal anti-inflammatory drugsAlternative drugsSelective hypersensitivityMultiple hypersensitivityDrug provocation testIntroduction: Hypersensitivity reactions to non-steroidal anti-inflammatory drugs (NSAIDs) are the most common reactions to drugs. The prevalence varies from 0.6 to 5.7% in general population, but there are no data available in children. The aim of this study is to determine the frequency of patients diagnosed with hypersensitivity to NSAIDs, and describe their clinical characteristics, type of hypersensitivity, and tolerance to alternative drugs. Methods: Retrospective study was conducted on children with suspected hypersensitivity to NSAIDs from January 2012 to December 2013. The diagnosis was confirmed by oral drug provocation test (DPT) to the drug involved in the group with a history of one episode, while in the group with a history of more than one episode with the same drug the diagnosis was based on clinical data. Subsequently, a DPT with acetylsalicylic acid (ASA) was done in order to classify hypersensitivity into selective or multiple. In those cases with a positive result, a DPT was performed with alternative drugs. Results: Out of a total of 93 children studied, 26 were diagnosed with hypersensitivity to NSAIDs: 7 confirmed by oral DPT, and 19 based on clinical data. Multiple hypersensitivity was diagnosed in 50% of patients. Ibuprofen was involved in all reactions. The most common clinical manifestation was angioedema (44%). Acetaminophen was the best tolerated alternative drug. Conclusions: More than one quarter (28%) of the population studied was diagnosed with hypersensitivity to NSAIDs, and 50% had multiple hypersensitivity. Acetaminophen is a safe alternative in children with hypersensitivity to NSAIDs. Meloxicam may be an alternative in cases that do not tolerate acetaminophen. (C) 2015 Asociacion Espanola de Pediatria. Published by Elsevier Espana, S.L.U. All rights reserved.EDICIONES DOYMA S A2016info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttps://fsjd.fundanetsuite.com/Publicaciones/ProdCientif/PublicacionFrw.aspx?id=12504ANALES DE PEDIATRIAISSN: 16954033ISSNe: 16959531reponame:r-FSJD. Repositorio Institucional de Producción Científica de la Fundació Sant Joan de Déuinstname:Fundació Sant Joan de DéuEspañolinfo:eu-repo/semantics/openAccessoai:fsjd.fundanetsuite.com:p125042026-05-27T12:37:41Z
dc.title.none.fl_str_mv Hypersensitivity reactions to non-steroidal anti-inflammatory drugs and tolerance to alternative drugs
title Hypersensitivity reactions to non-steroidal anti-inflammatory drugs and tolerance to alternative drugs
spellingShingle Hypersensitivity reactions to non-steroidal anti-inflammatory drugs and tolerance to alternative drugs
Calvo Campoverde K
Hypersensitivity to non-steroidal anti-inflammatory drugs
Alternative drugs
Selective hypersensitivity
Multiple hypersensitivity
Drug provocation test
title_short Hypersensitivity reactions to non-steroidal anti-inflammatory drugs and tolerance to alternative drugs
title_full Hypersensitivity reactions to non-steroidal anti-inflammatory drugs and tolerance to alternative drugs
title_fullStr Hypersensitivity reactions to non-steroidal anti-inflammatory drugs and tolerance to alternative drugs
title_full_unstemmed Hypersensitivity reactions to non-steroidal anti-inflammatory drugs and tolerance to alternative drugs
title_sort Hypersensitivity reactions to non-steroidal anti-inflammatory drugs and tolerance to alternative drugs
dc.creator.none.fl_str_mv Calvo Campoverde K
Giner-Muñoz MT
Martínez Valdez L
Rojas Volquez M
Lozano Blasco J
Machinena A
Plaza AM
author Calvo Campoverde K
author_facet Calvo Campoverde K
Giner-Muñoz MT
Martínez Valdez L
Rojas Volquez M
Lozano Blasco J
Machinena A
Plaza AM
author_role author
author2 Giner-Muñoz MT
Martínez Valdez L
Rojas Volquez M
Lozano Blasco J
Machinena A
Plaza AM
author2_role author
author
author
author
author
author
dc.subject.none.fl_str_mv Hypersensitivity to non-steroidal anti-inflammatory drugs
Alternative drugs
Selective hypersensitivity
Multiple hypersensitivity
Drug provocation test
topic Hypersensitivity to non-steroidal anti-inflammatory drugs
Alternative drugs
Selective hypersensitivity
Multiple hypersensitivity
Drug provocation test
description Introduction: Hypersensitivity reactions to non-steroidal anti-inflammatory drugs (NSAIDs) are the most common reactions to drugs. The prevalence varies from 0.6 to 5.7% in general population, but there are no data available in children. The aim of this study is to determine the frequency of patients diagnosed with hypersensitivity to NSAIDs, and describe their clinical characteristics, type of hypersensitivity, and tolerance to alternative drugs. Methods: Retrospective study was conducted on children with suspected hypersensitivity to NSAIDs from January 2012 to December 2013. The diagnosis was confirmed by oral drug provocation test (DPT) to the drug involved in the group with a history of one episode, while in the group with a history of more than one episode with the same drug the diagnosis was based on clinical data. Subsequently, a DPT with acetylsalicylic acid (ASA) was done in order to classify hypersensitivity into selective or multiple. In those cases with a positive result, a DPT was performed with alternative drugs. Results: Out of a total of 93 children studied, 26 were diagnosed with hypersensitivity to NSAIDs: 7 confirmed by oral DPT, and 19 based on clinical data. Multiple hypersensitivity was diagnosed in 50% of patients. Ibuprofen was involved in all reactions. The most common clinical manifestation was angioedema (44%). Acetaminophen was the best tolerated alternative drug. Conclusions: More than one quarter (28%) of the population studied was diagnosed with hypersensitivity to NSAIDs, and 50% had multiple hypersensitivity. Acetaminophen is a safe alternative in children with hypersensitivity to NSAIDs. Meloxicam may be an alternative in cases that do not tolerate acetaminophen. (C) 2015 Asociacion Espanola de Pediatria. Published by Elsevier Espana, S.L.U. All rights reserved.
publishDate 2016
dc.date.none.fl_str_mv 2016
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv https://fsjd.fundanetsuite.com/Publicaciones/ProdCientif/PublicacionFrw.aspx?id=12504
url https://fsjd.fundanetsuite.com/Publicaciones/ProdCientif/PublicacionFrw.aspx?id=12504
dc.language.none.fl_str_mv Español
language_invalid_str_mv Español
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.publisher.none.fl_str_mv EDICIONES DOYMA S A
publisher.none.fl_str_mv EDICIONES DOYMA S A
dc.source.none.fl_str_mv ANALES DE PEDIATRIA
ISSN: 16954033
ISSNe: 16959531
reponame:r-FSJD. Repositorio Institucional de Producción Científica de la Fundació Sant Joan de Déu
instname:Fundació Sant Joan de Déu
instname_str Fundació Sant Joan de Déu
reponame_str r-FSJD. Repositorio Institucional de Producción Científica de la Fundació Sant Joan de Déu
collection r-FSJD. Repositorio Institucional de Producción Científica de la Fundació Sant Joan de Déu
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