Vaccinated Patients Admitted in ICU with Severe Pneumonia Due to SARS-CoV-2: A Multicenter Pilot Study

Background: The aim of this study was to analyze the percentage of patients admitted to the ICU having received the vaccine against COVID-19, to describe the clinical profile of vaccinated patients admitted to the ICU, and to assess the humoral immune response to vaccination. Methods: In this multic...

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Autores: Estella, Ángel, Cantón Bulnes, María Luisa, Muñoz, Laura, Rodriguez Higueras, Isabel, Recuerda Núñez, María, Tejero Aranguren, Julia, Zaya, Benito, Garnacho Montero, José, Group Of Infectious Diseases Of The Andalusian Society Of Intensive Care And Coronary Units Samiuc
Tipo de recurso: artículo
Estado:Versión publicada
Fecha de publicación:2021
País:España
Institución:Universidad de Sevilla (US)
Repositorio:idUS. Depósito de Investigación de la Universidad de Sevilla
OAI Identifier:oai:idus.us.es:11441/173000
Acceso en línea:https://hdl.handle.net/11441/173000
https://doi.org/10.3390/jpm11111086
Access Level:acceso abierto
Palabra clave:SARS-CoV-2
Severe pneumonia
Acute respiratory distress syndrome
Vaccine
ICU
Delta variant SARS-CoV-2
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spelling Vaccinated Patients Admitted in ICU with Severe Pneumonia Due to SARS-CoV-2: A Multicenter Pilot StudyEstella, ÁngelCantón Bulnes, María LuisaMuñoz, LauraRodriguez Higueras, IsabelRecuerda Núñez, MaríaTejero Aranguren, JuliaZaya, BenitoGarnacho Montero, JoséGroup Of Infectious Diseases Of The Andalusian Society Of Intensive Care And Coronary Units SamiucSARS-CoV-2Severe pneumoniaAcute respiratory distress syndromeVaccineICUDelta variant SARS-CoV-2Background: The aim of this study was to analyze the percentage of patients admitted to the ICU having received the vaccine against COVID-19, to describe the clinical profile of vaccinated patients admitted to the ICU, and to assess the humoral immune response to vaccination. Methods: In this multicenter prospective descriptive cohort study, consecutive critically ill patients with confirmed SARS-CoV-2 pneumonia who received at least one dose of the SARS-CoV-2 vaccine were included. The time of study was from 1 July to 10 August of 2021. Results: Of the 94 consecutive patients from seven Andalusian ICUs admitted during the time of study, 50 (53.2%) received at least one dose of anti SARS-CoV-2 vaccine. No patient was admitted having previously had SARS-CoV-2 infection. The B.1.617.2 (Delta) variant was the most frequently identified, in 80.76% of cases. Patients with a complete vaccination with non-optimal antibody levels were immunocompromised. Fifteen patients were admitted to the ICU with Acute Respiratory Distress Syndrome (ARDS) without having completed their vaccination; the clinical profile was younger and with less comorbidities compared to patients with full vaccination. There were no differences in severity of ARDS. Conclusions: Most of the patients who were admitted to the ICU having received a dose of the vaccine were not optimally vaccinated; fully vaccinated patients who did not obtain optimal serum antibody levels were patients considered immunocompromised.MDPIMedicina2021info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionapplication/pdfapplication/pdfhttps://hdl.handle.net/11441/173000https://doi.org/10.3390/jpm11111086reponame:idUS. Depósito de Investigación de la Universidad de Sevillainstname:Universidad de Sevilla (US)InglésJournal of personalized medicine, 11 (11), 1086.https://www.mdpi.com/2075-4426/11/11/1086info:eu-repo/semantics/openAccessoai:idus.us.es:11441/1730002026-06-17T12:51:07Z
dc.title.none.fl_str_mv Vaccinated Patients Admitted in ICU with Severe Pneumonia Due to SARS-CoV-2: A Multicenter Pilot Study
title Vaccinated Patients Admitted in ICU with Severe Pneumonia Due to SARS-CoV-2: A Multicenter Pilot Study
spellingShingle Vaccinated Patients Admitted in ICU with Severe Pneumonia Due to SARS-CoV-2: A Multicenter Pilot Study
Estella, Ángel
SARS-CoV-2
Severe pneumonia
Acute respiratory distress syndrome
Vaccine
ICU
Delta variant SARS-CoV-2
title_short Vaccinated Patients Admitted in ICU with Severe Pneumonia Due to SARS-CoV-2: A Multicenter Pilot Study
title_full Vaccinated Patients Admitted in ICU with Severe Pneumonia Due to SARS-CoV-2: A Multicenter Pilot Study
title_fullStr Vaccinated Patients Admitted in ICU with Severe Pneumonia Due to SARS-CoV-2: A Multicenter Pilot Study
title_full_unstemmed Vaccinated Patients Admitted in ICU with Severe Pneumonia Due to SARS-CoV-2: A Multicenter Pilot Study
title_sort Vaccinated Patients Admitted in ICU with Severe Pneumonia Due to SARS-CoV-2: A Multicenter Pilot Study
dc.creator.none.fl_str_mv Estella, Ángel
Cantón Bulnes, María Luisa
Muñoz, Laura
Rodriguez Higueras, Isabel
Recuerda Núñez, María
Tejero Aranguren, Julia
Zaya, Benito
Garnacho Montero, José
Group Of Infectious Diseases Of The Andalusian Society Of Intensive Care And Coronary Units Samiuc
author Estella, Ángel
author_facet Estella, Ángel
Cantón Bulnes, María Luisa
Muñoz, Laura
Rodriguez Higueras, Isabel
Recuerda Núñez, María
Tejero Aranguren, Julia
Zaya, Benito
Garnacho Montero, José
Group Of Infectious Diseases Of The Andalusian Society Of Intensive Care And Coronary Units Samiuc
author_role author
author2 Cantón Bulnes, María Luisa
Muñoz, Laura
Rodriguez Higueras, Isabel
Recuerda Núñez, María
Tejero Aranguren, Julia
Zaya, Benito
Garnacho Montero, José
Group Of Infectious Diseases Of The Andalusian Society Of Intensive Care And Coronary Units Samiuc
author2_role author
author
author
author
author
author
author
author
dc.contributor.none.fl_str_mv Medicina
dc.subject.none.fl_str_mv SARS-CoV-2
Severe pneumonia
Acute respiratory distress syndrome
Vaccine
ICU
Delta variant SARS-CoV-2
topic SARS-CoV-2
Severe pneumonia
Acute respiratory distress syndrome
Vaccine
ICU
Delta variant SARS-CoV-2
description Background: The aim of this study was to analyze the percentage of patients admitted to the ICU having received the vaccine against COVID-19, to describe the clinical profile of vaccinated patients admitted to the ICU, and to assess the humoral immune response to vaccination. Methods: In this multicenter prospective descriptive cohort study, consecutive critically ill patients with confirmed SARS-CoV-2 pneumonia who received at least one dose of the SARS-CoV-2 vaccine were included. The time of study was from 1 July to 10 August of 2021. Results: Of the 94 consecutive patients from seven Andalusian ICUs admitted during the time of study, 50 (53.2%) received at least one dose of anti SARS-CoV-2 vaccine. No patient was admitted having previously had SARS-CoV-2 infection. The B.1.617.2 (Delta) variant was the most frequently identified, in 80.76% of cases. Patients with a complete vaccination with non-optimal antibody levels were immunocompromised. Fifteen patients were admitted to the ICU with Acute Respiratory Distress Syndrome (ARDS) without having completed their vaccination; the clinical profile was younger and with less comorbidities compared to patients with full vaccination. There were no differences in severity of ARDS. Conclusions: Most of the patients who were admitted to the ICU having received a dose of the vaccine were not optimally vaccinated; fully vaccinated patients who did not obtain optimal serum antibody levels were patients considered immunocompromised.
publishDate 2021
dc.date.none.fl_str_mv 2021
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv https://hdl.handle.net/11441/173000
https://doi.org/10.3390/jpm11111086
url https://hdl.handle.net/11441/173000
https://doi.org/10.3390/jpm11111086
dc.language.none.fl_str_mv Inglés
language_invalid_str_mv Inglés
dc.relation.none.fl_str_mv Journal of personalized medicine, 11 (11), 1086.
https://www.mdpi.com/2075-4426/11/11/1086
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
application/pdf
dc.publisher.none.fl_str_mv MDPI
publisher.none.fl_str_mv MDPI
dc.source.none.fl_str_mv reponame:idUS. Depósito de Investigación de la Universidad de Sevilla
instname:Universidad de Sevilla (US)
instname_str Universidad de Sevilla (US)
reponame_str idUS. Depósito de Investigación de la Universidad de Sevilla
collection idUS. Depósito de Investigación de la Universidad de Sevilla
repository.name.fl_str_mv
repository.mail.fl_str_mv
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