Pretransplant CMV-Specific T-Cell Immunity But Not Dose of Antithymocyte Globulin Is Associated With Recovery of Specific Immunity After Kidney Transplantation

Background: This is a prospective, multicenter, observational study in cytomegalovirus (CMV)-seropositive kidney transplant recipients with pretransplant CMV-specific cell-mediated immunity (CMV-CMI) receiving antithymocyte globulin (ATG). We aimed to investigate posttransplant CMV-CMI over time and...

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Autores: Páez Vega, Aurora, Cantisán, Sara, Agüera, María Luisa, Suñer, Marta, Facundo, Carmen, Yuste, Jose R., Fernández Ruiz, Mario, Montejo, Miguel, Redondo Pachón, Dolores, López Oliva, María O., Fernández Rodríguez, Ana, Fariñas Álvarez, María del Carmen, Hernández, Domingo, Len, Óscar, Muñoz, Patricia, Valle Arroyo, Jorge, Rodelo Haad, Cristian, Cordero, Elisa, Torre Cisneros, Elisa
Tipo de recurso: artículo
Fecha de publicación:2020
País:España
Institución:Universidad de Cantabria (UC)
Repositorio:UCrea Repositorio Abierto de la Universidad de Cantabria
Idioma:inglés
OAI Identifier:oai:repositorio.unican.es:10902/24486
Acceso en línea:http://hdl.handle.net/10902/24486
Access Level:acceso abierto
Palabra clave:Cytomegalovirus infection
Kidney transplant
Kinetics of CMV-specific cell-mediated immunity
QuantiFERONCMV assay
Antithymocyte globulin
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spelling Pretransplant CMV-Specific T-Cell Immunity But Not Dose of Antithymocyte Globulin Is Associated With Recovery of Specific Immunity After Kidney TransplantationPáez Vega, AuroraCantisán, SaraAgüera, María LuisaSuñer, MartaFacundo, CarmenYuste, Jose R.Fernández Ruiz, MarioMontejo, MiguelRedondo Pachón, DoloresLópez Oliva, María O.Fernández Rodríguez, AnaFariñas Álvarez, María del CarmenHernández, DomingoLen, ÓscarMuñoz, PatriciaValle Arroyo, JorgeRodelo Haad, CristianCordero, ElisaTorre Cisneros, ElisaCytomegalovirus infectionKidney transplantKinetics of CMV-specific cell-mediated immunityQuantiFERONCMV assayAntithymocyte globulinBackground: This is a prospective, multicenter, observational study in cytomegalovirus (CMV)-seropositive kidney transplant recipients with pretransplant CMV-specific cell-mediated immunity (CMV-CMI) receiving antithymocyte globulin (ATG). We aimed to investigate posttransplant CMV-CMI over time and the impact of the dose-dependent ATG. Methods: CMV-CMI was assessed at days +30, +45, +60, and +90 after transplantation with the QuantiFERON-CMV assay. A reactive result (interferon-? [IFN-?] ? 0.2 IU/mL) indicated a positive CMV-CMI. Results: A total of 78 positive CMV-CMI patients were enrolled in the study, of which 59.5% had a positive CMV-CMI at day +30 and 82.7% at day +90. Multivariate logistic regression analysis showed that ATG dose was not associated with positive CMV-CMI at any point. However, pretransplant IFN-? level (>12 IU/mL vs ?12 IU/mL) was associated with positive CMV-CMI at day +30 (odds ratio, 12.9; 95% confidence interval, 3.1-53.3; P < .001). In addition, all the patients who did not recover CMV-CMI at day +90 had a pretransplant IFN-? level ?12 IU/mL. Conclusions: More than half of CMV-seropositive kidney transplant recipients receiving ATG recover (or maintain) CMV-CMI by the first month after transplantation. The pretransplant IFN-? level, but not the ATG dose, shows a strong association with the kinetics of this recovery.This work was supported by the Fundación Progreso y Salud, Consejería de Salud y Familias, Junta de Andalucía (grant number PI-0294-2014); Spanish Ministry of Science and Innovation, Instituto de Salud Carlos III (grant number CP 18/00073 to M. F. R.); Plan Nacional de I+D+i 2013–2016 and Instituto de Salud Carlos III, Subdirección General de Redes y Centros de Investigación Cooperativa, Ministerio de Ciencia e Innovación, Spanish Network for Research in Infectious Diseases (grant numbers REIPI RD16/0016/0002, RD16/0016/0003, RD16/0016/0007, RD16/0016/0008, RD16/0016/0009 and RD16/0016/0012); cofinanced by European Development Regional Fund “A way to achieve Europe,” Operative Program Intelligent Growth 2014- 2020; Spanish Network for Research in Renal Diseases (grant numbers RD16/0009/0006, RD16/0009/0008, RD16/0009/0013, RD16/0009/0014, RD16/0009/0019, RD16/0009/0034); Centro de Investigación Biomédica en Red Enfermedades Respiratorias (grant number CB06/06/0058); and Spanish Group for the Study of Infection in Transplantation and the Immunocompromised Host of the Spanish Society of Infectious Diseases and Clinical MicrobiologyOxford University PressUniversidad de Cantabria20202020-01-01journal articlehttp://purl.org/coar/resource_type/c_6501NAhttp://purl.org/coar/version/c_be7fb7dd8ff6fe43info:eu-repo/semantics/articlehttp://hdl.handle.net/10902/24486J Infect Dis . 2021 Apr 8;223(7):1205-1213reponame:UCrea Repositorio Abierto de la Universidad de Cantabriainstname:Universidad de Cantabria (UC)Inglésengopen accesshttp://purl.org/coar/access_right/c_abf2info:eu-repo/semantics/openAccessoai:repositorio.unican.es:10902/244862026-06-02T12:39:31Z
dc.title.none.fl_str_mv Pretransplant CMV-Specific T-Cell Immunity But Not Dose of Antithymocyte Globulin Is Associated With Recovery of Specific Immunity After Kidney Transplantation
title Pretransplant CMV-Specific T-Cell Immunity But Not Dose of Antithymocyte Globulin Is Associated With Recovery of Specific Immunity After Kidney Transplantation
spellingShingle Pretransplant CMV-Specific T-Cell Immunity But Not Dose of Antithymocyte Globulin Is Associated With Recovery of Specific Immunity After Kidney Transplantation
Páez Vega, Aurora
Cytomegalovirus infection
Kidney transplant
Kinetics of CMV-specific cell-mediated immunity
QuantiFERONCMV assay
Antithymocyte globulin
title_short Pretransplant CMV-Specific T-Cell Immunity But Not Dose of Antithymocyte Globulin Is Associated With Recovery of Specific Immunity After Kidney Transplantation
title_full Pretransplant CMV-Specific T-Cell Immunity But Not Dose of Antithymocyte Globulin Is Associated With Recovery of Specific Immunity After Kidney Transplantation
title_fullStr Pretransplant CMV-Specific T-Cell Immunity But Not Dose of Antithymocyte Globulin Is Associated With Recovery of Specific Immunity After Kidney Transplantation
title_full_unstemmed Pretransplant CMV-Specific T-Cell Immunity But Not Dose of Antithymocyte Globulin Is Associated With Recovery of Specific Immunity After Kidney Transplantation
title_sort Pretransplant CMV-Specific T-Cell Immunity But Not Dose of Antithymocyte Globulin Is Associated With Recovery of Specific Immunity After Kidney Transplantation
dc.creator.none.fl_str_mv Páez Vega, Aurora
Cantisán, Sara
Agüera, María Luisa
Suñer, Marta
Facundo, Carmen
Yuste, Jose R.
Fernández Ruiz, Mario
Montejo, Miguel
Redondo Pachón, Dolores
López Oliva, María O.
Fernández Rodríguez, Ana
Fariñas Álvarez, María del Carmen
Hernández, Domingo
Len, Óscar
Muñoz, Patricia
Valle Arroyo, Jorge
Rodelo Haad, Cristian
Cordero, Elisa
Torre Cisneros, Elisa
author Páez Vega, Aurora
author_facet Páez Vega, Aurora
Cantisán, Sara
Agüera, María Luisa
Suñer, Marta
Facundo, Carmen
Yuste, Jose R.
Fernández Ruiz, Mario
Montejo, Miguel
Redondo Pachón, Dolores
López Oliva, María O.
Fernández Rodríguez, Ana
Fariñas Álvarez, María del Carmen
Hernández, Domingo
Len, Óscar
Muñoz, Patricia
Valle Arroyo, Jorge
Rodelo Haad, Cristian
Cordero, Elisa
Torre Cisneros, Elisa
author_role author
author2 Cantisán, Sara
Agüera, María Luisa
Suñer, Marta
Facundo, Carmen
Yuste, Jose R.
Fernández Ruiz, Mario
Montejo, Miguel
Redondo Pachón, Dolores
López Oliva, María O.
Fernández Rodríguez, Ana
Fariñas Álvarez, María del Carmen
Hernández, Domingo
Len, Óscar
Muñoz, Patricia
Valle Arroyo, Jorge
Rodelo Haad, Cristian
Cordero, Elisa
Torre Cisneros, Elisa
author2_role author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
dc.contributor.none.fl_str_mv Universidad de Cantabria
dc.subject.none.fl_str_mv Cytomegalovirus infection
Kidney transplant
Kinetics of CMV-specific cell-mediated immunity
QuantiFERONCMV assay
Antithymocyte globulin
topic Cytomegalovirus infection
Kidney transplant
Kinetics of CMV-specific cell-mediated immunity
QuantiFERONCMV assay
Antithymocyte globulin
description Background: This is a prospective, multicenter, observational study in cytomegalovirus (CMV)-seropositive kidney transplant recipients with pretransplant CMV-specific cell-mediated immunity (CMV-CMI) receiving antithymocyte globulin (ATG). We aimed to investigate posttransplant CMV-CMI over time and the impact of the dose-dependent ATG. Methods: CMV-CMI was assessed at days +30, +45, +60, and +90 after transplantation with the QuantiFERON-CMV assay. A reactive result (interferon-? [IFN-?] ? 0.2 IU/mL) indicated a positive CMV-CMI. Results: A total of 78 positive CMV-CMI patients were enrolled in the study, of which 59.5% had a positive CMV-CMI at day +30 and 82.7% at day +90. Multivariate logistic regression analysis showed that ATG dose was not associated with positive CMV-CMI at any point. However, pretransplant IFN-? level (>12 IU/mL vs ?12 IU/mL) was associated with positive CMV-CMI at day +30 (odds ratio, 12.9; 95% confidence interval, 3.1-53.3; P < .001). In addition, all the patients who did not recover CMV-CMI at day +90 had a pretransplant IFN-? level ?12 IU/mL. Conclusions: More than half of CMV-seropositive kidney transplant recipients receiving ATG recover (or maintain) CMV-CMI by the first month after transplantation. The pretransplant IFN-? level, but not the ATG dose, shows a strong association with the kinetics of this recovery.
publishDate 2020
dc.date.none.fl_str_mv 2020
2020-01-01
dc.type.none.fl_str_mv journal article
http://purl.org/coar/resource_type/c_6501
NA
http://purl.org/coar/version/c_be7fb7dd8ff6fe43
dc.type.openaire.fl_str_mv info:eu-repo/semantics/article
format article
dc.identifier.none.fl_str_mv http://hdl.handle.net/10902/24486
url http://hdl.handle.net/10902/24486
dc.language.none.fl_str_mv Inglés
eng
language_invalid_str_mv Inglés
language eng
dc.rights.none.fl_str_mv open access
http://purl.org/coar/access_right/c_abf2
dc.rights.openaire.fl_str_mv info:eu-repo/semantics/openAccess
rights_invalid_str_mv open access
http://purl.org/coar/access_right/c_abf2
eu_rights_str_mv openAccess
dc.publisher.none.fl_str_mv Oxford University Press
publisher.none.fl_str_mv Oxford University Press
dc.source.none.fl_str_mv J Infect Dis . 2021 Apr 8;223(7):1205-1213
reponame:UCrea Repositorio Abierto de la Universidad de Cantabria
instname:Universidad de Cantabria (UC)
instname_str Universidad de Cantabria (UC)
reponame_str UCrea Repositorio Abierto de la Universidad de Cantabria
collection UCrea Repositorio Abierto de la Universidad de Cantabria
repository.name.fl_str_mv
repository.mail.fl_str_mv
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score 15,300719

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