Slow-wave activity homeostasis in the somatosensory cortex after spinal cord injury

The cortical reorganization after spinal cord injury (SCI) involves a series of physiological changes that drive the expansion of the intact cortical area to the deafferented cortical area. These changes have always been studied under a stimulus-response paradigm, which demonstrates that the deaffer...

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Autor: Aguilar Lepe, Juan de los Reyes
Tipo de recurso: artículo
Fecha de publicación:2019
País:España
Institución:Universidad de Castilla-La Mancha
Repositorio:RUIdeRA. Repositorio Institucional de la UCLM
OAI Identifier:oai:ruidera.uclm.es:10578/41342
Acceso en línea:http://10.1016/j.expneurol.2019.113035
https://hdl.handle.net/10578/41342
Access Level:acceso abierto
Palabra clave:Acute and chronic spinal cord injury
Cortical excitability
In vivo neurophysiology
Neural homeostasis
Slow-wave activity
Somatosensory cortex
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spelling Slow-wave activity homeostasis in the somatosensory cortex after spinal cord injuryAguilar Lepe, Juan de los ReyesAcute and chronic spinal cord injuryCortical excitabilityIn vivo neurophysiologyNeural homeostasisSlow-wave activitySomatosensory cortexThe cortical reorganization after spinal cord injury (SCI) involves a series of physiological changes that drive the expansion of the intact cortical area to the deafferented cortical area. These changes have always been studied under a stimulus-response paradigm, which demonstrates that the deafferented cortex becomes more responsive to stimulation of body regions above the level of the lesion. However, less is known about how permanent large-scale deafferentation affects spontaneous activity in the somatosensory cortex, an important physiological feature related to the processing of peripheral inputs and perception. Here we studied the spontaneous activity at two sites of the somatosensory cortex, corresponding to forepaw and hindpaw, and at three different time points after SCI: acute SCI, one week post-SCI and chronic SCI (1–3 months after injury). Electrophysiological recordings from anesthetized rats were obtained in conditions of slow-wave activity in order to compare features of the neural populations in periods of cortical up-states. Our data demonstrate that acute SCI reduces the excitability of cortical neurons during up-states in both the forepaw and the hindpaw cortex. One week after SCI, the properties of cortical neurons were similar to those under control conditions, indicating a homeostatic plasticity. Finally, chronic SCI increased neural activity during up-states, while reduced up-state frequency in the cortex. We conclude that SCI induces different homeostatic changes in cortical slow-wave depending on the time after lesion. This temporal evolution of spontaneous activity could help better understand the cortical plasticity associated with acute or chronic SCI.Academic Press Inc.202520252019info:eu-repo/semantics/articleapplication/pdfapplication/pdfhttp://10.1016/j.expneurol.2019.113035https://hdl.handle.net/10578/41342reponame:RUIdeRA. Repositorio Institucional de la UCLMinstname:Universidad de Castilla-La ManchaInglésinfo:eu-repo/semantics/openAccessoai:ruidera.uclm.es:10578/413422026-05-27T07:36:41Z
dc.title.none.fl_str_mv Slow-wave activity homeostasis in the somatosensory cortex after spinal cord injury
title Slow-wave activity homeostasis in the somatosensory cortex after spinal cord injury
spellingShingle Slow-wave activity homeostasis in the somatosensory cortex after spinal cord injury
Aguilar Lepe, Juan de los Reyes
Acute and chronic spinal cord injury
Cortical excitability
In vivo neurophysiology
Neural homeostasis
Slow-wave activity
Somatosensory cortex
title_short Slow-wave activity homeostasis in the somatosensory cortex after spinal cord injury
title_full Slow-wave activity homeostasis in the somatosensory cortex after spinal cord injury
title_fullStr Slow-wave activity homeostasis in the somatosensory cortex after spinal cord injury
title_full_unstemmed Slow-wave activity homeostasis in the somatosensory cortex after spinal cord injury
title_sort Slow-wave activity homeostasis in the somatosensory cortex after spinal cord injury
dc.creator.none.fl_str_mv Aguilar Lepe, Juan de los Reyes
author Aguilar Lepe, Juan de los Reyes
author_facet Aguilar Lepe, Juan de los Reyes
author_role author
dc.subject.none.fl_str_mv Acute and chronic spinal cord injury
Cortical excitability
In vivo neurophysiology
Neural homeostasis
Slow-wave activity
Somatosensory cortex
topic Acute and chronic spinal cord injury
Cortical excitability
In vivo neurophysiology
Neural homeostasis
Slow-wave activity
Somatosensory cortex
description The cortical reorganization after spinal cord injury (SCI) involves a series of physiological changes that drive the expansion of the intact cortical area to the deafferented cortical area. These changes have always been studied under a stimulus-response paradigm, which demonstrates that the deafferented cortex becomes more responsive to stimulation of body regions above the level of the lesion. However, less is known about how permanent large-scale deafferentation affects spontaneous activity in the somatosensory cortex, an important physiological feature related to the processing of peripheral inputs and perception. Here we studied the spontaneous activity at two sites of the somatosensory cortex, corresponding to forepaw and hindpaw, and at three different time points after SCI: acute SCI, one week post-SCI and chronic SCI (1–3 months after injury). Electrophysiological recordings from anesthetized rats were obtained in conditions of slow-wave activity in order to compare features of the neural populations in periods of cortical up-states. Our data demonstrate that acute SCI reduces the excitability of cortical neurons during up-states in both the forepaw and the hindpaw cortex. One week after SCI, the properties of cortical neurons were similar to those under control conditions, indicating a homeostatic plasticity. Finally, chronic SCI increased neural activity during up-states, while reduced up-state frequency in the cortex. We conclude that SCI induces different homeostatic changes in cortical slow-wave depending on the time after lesion. This temporal evolution of spontaneous activity could help better understand the cortical plasticity associated with acute or chronic SCI.
publishDate 2019
dc.date.none.fl_str_mv 2019
2025
2025
dc.type.none.fl_str_mv info:eu-repo/semantics/article
format article
dc.identifier.none.fl_str_mv http://10.1016/j.expneurol.2019.113035
https://hdl.handle.net/10578/41342
url http://10.1016/j.expneurol.2019.113035
https://hdl.handle.net/10578/41342
dc.language.none.fl_str_mv Inglés
language_invalid_str_mv Inglés
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
application/pdf
dc.publisher.none.fl_str_mv Academic Press Inc.
publisher.none.fl_str_mv Academic Press Inc.
dc.source.none.fl_str_mv reponame:RUIdeRA. Repositorio Institucional de la UCLM
instname:Universidad de Castilla-La Mancha
instname_str Universidad de Castilla-La Mancha
reponame_str RUIdeRA. Repositorio Institucional de la UCLM
collection RUIdeRA. Repositorio Institucional de la UCLM
repository.name.fl_str_mv
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