Management Of Tizanidine Withdrawal Syndrome: A Case Report

Most drugs that act on the central nervous system (CNS) require dose titration to avoid withdrawal syndrome. Tizanidine withdrawal syndrome is caused by adrenergic discharge due to its alpha(2)-agonist mechanism and is characterized by hypertension, reflex tachycardia, hypertonicity, and anxiety. Al...

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Autores: Suarez Lledó, A., Padullés Zamora, Ariadna, Lozano, T., Cobo Sacristán, Sara, Colls González, Montserrat, Jódar Masanés, Ramón José
Tipo de recurso: artículo
Estado:Versión publicada
Fecha de publicación:2018
País:España
Institución:Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)
Repositorio:Recercat. Dipósit de la Recerca de Catalunya
OAI Identifier:oai:recercat.cat:2445/124013
Acceso en línea:https://hdl.handle.net/2445/124013
Access Level:acceso abierto
Palabra clave:Síndrome d'abstinència
Hipertensió
Drug withdrawal symptoms
Hypertension
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spelling Management Of Tizanidine Withdrawal Syndrome: A Case ReportSuarez Lledó, A.Padullés Zamora, AriadnaLozano, T.Cobo Sacristán, SaraColls González, MontserratJódar Masanés, Ramón JoséSíndrome d'abstinènciaHipertensióDrug withdrawal symptomsHypertensionMost drugs that act on the central nervous system (CNS) require dose titration to avoid withdrawal syndrome. Tizanidine withdrawal syndrome is caused by adrenergic discharge due to its alpha(2)-agonist mechanism and is characterized by hypertension, reflex tachycardia, hypertonicity, and anxiety. Although tizanidine withdrawal syndrome is mentioned as a potential side effect of cessation, it is not common and there have been few reports. We present the case of a 31-year-old woman with tizanidine withdrawal syndrome after discontinuing medication prescribed for a muscle contracture (tizanidine). She showed high adrenergic activity with nausea, vomiting, generalized tremor, dysthermia, hypertension, and tachycardia. Symptoms were reversed and successful reweaning was achieved by restarting tizanidine followed by slow downward titration. Withdrawal syndrome should be considered when drugs targeting the CNS are suddenly stopped. Weaning regimens should be closely monitored for acute withdrawal reactions.Sage Publications2018201820182018info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersion3 p.application/pdfhttps://hdl.handle.net/2445/124013Articles publicats en revistes (Institut d'lnvestigació Biomèdica de Bellvitge (IDIBELL))reponame:Recercat. Dipósit de la Recerca de Catalunyainstname:Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)InglésReproducció del document publicat a: http://dx.doi.org/10.1177/1179547618758022Clinical Medicine Insights: Case Reports, 2018, vol. 11http://dx.doi.org/10.1177/1179547618758022cc by-nc (c) Sage, 2018http://creativecommons.org/licenses/by-nc/3.0/es/info:eu-repo/semantics/openAccessoai:recercat.cat:2445/1240132026-05-29T05:05:01Z
dc.title.none.fl_str_mv Management Of Tizanidine Withdrawal Syndrome: A Case Report
title Management Of Tizanidine Withdrawal Syndrome: A Case Report
spellingShingle Management Of Tizanidine Withdrawal Syndrome: A Case Report
Suarez Lledó, A.
Síndrome d'abstinència
Hipertensió
Drug withdrawal symptoms
Hypertension
title_short Management Of Tizanidine Withdrawal Syndrome: A Case Report
title_full Management Of Tizanidine Withdrawal Syndrome: A Case Report
title_fullStr Management Of Tizanidine Withdrawal Syndrome: A Case Report
title_full_unstemmed Management Of Tizanidine Withdrawal Syndrome: A Case Report
title_sort Management Of Tizanidine Withdrawal Syndrome: A Case Report
dc.creator.none.fl_str_mv Suarez Lledó, A.
Padullés Zamora, Ariadna
Lozano, T.
Cobo Sacristán, Sara
Colls González, Montserrat
Jódar Masanés, Ramón José
author Suarez Lledó, A.
author_facet Suarez Lledó, A.
Padullés Zamora, Ariadna
Lozano, T.
Cobo Sacristán, Sara
Colls González, Montserrat
Jódar Masanés, Ramón José
author_role author
author2 Padullés Zamora, Ariadna
Lozano, T.
Cobo Sacristán, Sara
Colls González, Montserrat
Jódar Masanés, Ramón José
author2_role author
author
author
author
author
dc.subject.none.fl_str_mv Síndrome d'abstinència
Hipertensió
Drug withdrawal symptoms
Hypertension
topic Síndrome d'abstinència
Hipertensió
Drug withdrawal symptoms
Hypertension
description Most drugs that act on the central nervous system (CNS) require dose titration to avoid withdrawal syndrome. Tizanidine withdrawal syndrome is caused by adrenergic discharge due to its alpha(2)-agonist mechanism and is characterized by hypertension, reflex tachycardia, hypertonicity, and anxiety. Although tizanidine withdrawal syndrome is mentioned as a potential side effect of cessation, it is not common and there have been few reports. We present the case of a 31-year-old woman with tizanidine withdrawal syndrome after discontinuing medication prescribed for a muscle contracture (tizanidine). She showed high adrenergic activity with nausea, vomiting, generalized tremor, dysthermia, hypertension, and tachycardia. Symptoms were reversed and successful reweaning was achieved by restarting tizanidine followed by slow downward titration. Withdrawal syndrome should be considered when drugs targeting the CNS are suddenly stopped. Weaning regimens should be closely monitored for acute withdrawal reactions.
publishDate 2018
dc.date.none.fl_str_mv 2018
2018
2018
2018
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv https://hdl.handle.net/2445/124013
url https://hdl.handle.net/2445/124013
dc.language.none.fl_str_mv Inglés
language_invalid_str_mv Inglés
dc.relation.none.fl_str_mv Reproducció del document publicat a: http://dx.doi.org/10.1177/1179547618758022
Clinical Medicine Insights: Case Reports, 2018, vol. 11
http://dx.doi.org/10.1177/1179547618758022
dc.rights.none.fl_str_mv cc by-nc (c) Sage, 2018
http://creativecommons.org/licenses/by-nc/3.0/es/
info:eu-repo/semantics/openAccess
rights_invalid_str_mv cc by-nc (c) Sage, 2018
http://creativecommons.org/licenses/by-nc/3.0/es/
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv 3 p.
application/pdf
dc.publisher.none.fl_str_mv Sage Publications
publisher.none.fl_str_mv Sage Publications
dc.source.none.fl_str_mv Articles publicats en revistes (Institut d'lnvestigació Biomèdica de Bellvitge (IDIBELL))
reponame:Recercat. Dipósit de la Recerca de Catalunya
instname:Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)
instname_str Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)
reponame_str Recercat. Dipósit de la Recerca de Catalunya
collection Recercat. Dipósit de la Recerca de Catalunya
repository.name.fl_str_mv
repository.mail.fl_str_mv
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