Local Prefrontal Cortex TMS-Induced Reactivity Is Related to Working Memory and Reasoning in Middle-Aged Adults
Introduction: The prefrontal cortex (PFC) plays a crucial role in cognition, particularly in executive functions. Cortical reactivity measured with Transcranial Magnetic Stimulation combined with Electroencephalography (TMS-EEG) is altered in pathological conditions, and it may also be a marker of c...
| Autores: | , , , , , , , , , , , , , |
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| Tipo de recurso: | artículo |
| Estado: | Versión publicada |
| Fecha de publicación: | 2022 |
| País: | España |
| Institución: | Universidad de Barcelona |
| Repositorio: | Dipòsit Digital de la UB |
| OAI Identifier: | oai:diposit.ub.edu:2445/192212 |
| Acceso en línea: | https://hdl.handle.net/2445/192212 |
| Access Level: | acceso abierto |
| Palabra clave: | Cervell Electroencefalografia Cognició Brain Electroencephalography Cognition |
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Local Prefrontal Cortex TMS-Induced Reactivity Is Related to Working Memory and Reasoning in Middle-Aged AdultsRedondo-Camós, MaríaCattaneo, GabrielePerellón Alfonso, RubenAlviarez Schulze, VanessaMorris, Timothy PeterSolana Sánchez, JavierEspaña-Irla, gorettiDelgado Gallén, SelmaPachón García, CatherineAlbu, SergiuZetterberg, HenrikTormos, José MaríaPascual Leone, Álvaro, 1961-Bartrés Faz, DavidCervellElectroencefalografiaCognicióBrainElectroencephalographyCognitionIntroduction: The prefrontal cortex (PFC) plays a crucial role in cognition, particularly in executive functions. Cortical reactivity measured with Transcranial Magnetic Stimulation combined with Electroencephalography (TMS-EEG) is altered in pathological conditions, and it may also be a marker of cognitive status in middle-aged adults. In this study, we investigated the associations between cognitive measures and TMS evoked EEG reactivity and explored whether the effects of this relationship were related to neurofilament light chain levels (NfL), a marker of neuroaxonal damage. Methods: Fifty two healthy middle-aged adults (41-65 years) from the Barcelona Brain Health Initiative cohort underwent TMS-EEG, a comprehensive neuropsychological assessment, and a blood test for NfL levels. Global and Local Mean-Field Power (GMFP/LMFP), two measures of cortical reactivity, were quantified after left prefrontal cortex (L-PFC) stimulation, and cognition was set as the outcome of the regression analysis. The left inferior parietal lobe (L-IPL) was used as a control stimulation condition. Results: Local reactivity was significantly associated with working memory and reasoning only after L-PFC stimulation. No associations were found between NfL and cognition. These specific associations were independent of the status of neuroaxonal damage indexed by the NfL biomarker and remained after adjusting for age, biological sex, and education. Conclusion: Our results demonstrate that TMS evoked EEG reactivity at the L-PFC, but not the L-IPL, is related to the cognitive status of middle-aged individuals and independent of NfL levels, and may become a valuable biomarker of frontal lobe-associated cognitive function. Keywords: Electroencephalography; TMS-EEG; cognition; cortical reactivity; prefrontal cortex (PFC); transcranial magnetic stimulation (TMS).Frontiers Media2022info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionapplication/pdfhttps://hdl.handle.net/2445/192212Articles publicats en revistes (Medicina)reponame:Dipòsit Digital de la UBinstname:Universidad de BarcelonaInglésReproducció del document publicat a: https://doi.org/10.3389/fpsyg.2022.813444Frontiers in Psychology, 2022https://doi.org/10.3389/fpsyg.2022.813444cc-by (c) Redondo-Camós, María et al., 2022https://creativecommons.org/licenses/by/4.0/info:eu-repo/semantics/openAccessoai:diposit.ub.edu:2445/1922122026-05-27T06:46:51Z |
| dc.title.none.fl_str_mv |
Local Prefrontal Cortex TMS-Induced Reactivity Is Related to Working Memory and Reasoning in Middle-Aged Adults |
| title |
Local Prefrontal Cortex TMS-Induced Reactivity Is Related to Working Memory and Reasoning in Middle-Aged Adults |
| spellingShingle |
Local Prefrontal Cortex TMS-Induced Reactivity Is Related to Working Memory and Reasoning in Middle-Aged Adults Redondo-Camós, María Cervell Electroencefalografia Cognició Brain Electroencephalography Cognition |
| title_short |
Local Prefrontal Cortex TMS-Induced Reactivity Is Related to Working Memory and Reasoning in Middle-Aged Adults |
| title_full |
Local Prefrontal Cortex TMS-Induced Reactivity Is Related to Working Memory and Reasoning in Middle-Aged Adults |
| title_fullStr |
Local Prefrontal Cortex TMS-Induced Reactivity Is Related to Working Memory and Reasoning in Middle-Aged Adults |
| title_full_unstemmed |
Local Prefrontal Cortex TMS-Induced Reactivity Is Related to Working Memory and Reasoning in Middle-Aged Adults |
| title_sort |
Local Prefrontal Cortex TMS-Induced Reactivity Is Related to Working Memory and Reasoning in Middle-Aged Adults |
| dc.creator.none.fl_str_mv |
Redondo-Camós, María Cattaneo, Gabriele Perellón Alfonso, Ruben Alviarez Schulze, Vanessa Morris, Timothy Peter Solana Sánchez, Javier España-Irla, goretti Delgado Gallén, Selma Pachón García, Catherine Albu, Sergiu Zetterberg, Henrik Tormos, José María Pascual Leone, Álvaro, 1961- Bartrés Faz, David |
| author |
Redondo-Camós, María |
| author_facet |
Redondo-Camós, María Cattaneo, Gabriele Perellón Alfonso, Ruben Alviarez Schulze, Vanessa Morris, Timothy Peter Solana Sánchez, Javier España-Irla, goretti Delgado Gallén, Selma Pachón García, Catherine Albu, Sergiu Zetterberg, Henrik Tormos, José María Pascual Leone, Álvaro, 1961- Bartrés Faz, David |
| author_role |
author |
| author2 |
Cattaneo, Gabriele Perellón Alfonso, Ruben Alviarez Schulze, Vanessa Morris, Timothy Peter Solana Sánchez, Javier España-Irla, goretti Delgado Gallén, Selma Pachón García, Catherine Albu, Sergiu Zetterberg, Henrik Tormos, José María Pascual Leone, Álvaro, 1961- Bartrés Faz, David |
| author2_role |
author author author author author author author author author author author author author |
| dc.subject.none.fl_str_mv |
Cervell Electroencefalografia Cognició Brain Electroencephalography Cognition |
| topic |
Cervell Electroencefalografia Cognició Brain Electroencephalography Cognition |
| description |
Introduction: The prefrontal cortex (PFC) plays a crucial role in cognition, particularly in executive functions. Cortical reactivity measured with Transcranial Magnetic Stimulation combined with Electroencephalography (TMS-EEG) is altered in pathological conditions, and it may also be a marker of cognitive status in middle-aged adults. In this study, we investigated the associations between cognitive measures and TMS evoked EEG reactivity and explored whether the effects of this relationship were related to neurofilament light chain levels (NfL), a marker of neuroaxonal damage. Methods: Fifty two healthy middle-aged adults (41-65 years) from the Barcelona Brain Health Initiative cohort underwent TMS-EEG, a comprehensive neuropsychological assessment, and a blood test for NfL levels. Global and Local Mean-Field Power (GMFP/LMFP), two measures of cortical reactivity, were quantified after left prefrontal cortex (L-PFC) stimulation, and cognition was set as the outcome of the regression analysis. The left inferior parietal lobe (L-IPL) was used as a control stimulation condition. Results: Local reactivity was significantly associated with working memory and reasoning only after L-PFC stimulation. No associations were found between NfL and cognition. These specific associations were independent of the status of neuroaxonal damage indexed by the NfL biomarker and remained after adjusting for age, biological sex, and education. Conclusion: Our results demonstrate that TMS evoked EEG reactivity at the L-PFC, but not the L-IPL, is related to the cognitive status of middle-aged individuals and independent of NfL levels, and may become a valuable biomarker of frontal lobe-associated cognitive function. Keywords: Electroencephalography; TMS-EEG; cognition; cortical reactivity; prefrontal cortex (PFC); transcranial magnetic stimulation (TMS). |
| publishDate |
2022 |
| dc.date.none.fl_str_mv |
2022 |
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info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion |
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article |
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publishedVersion |
| dc.identifier.none.fl_str_mv |
https://hdl.handle.net/2445/192212 |
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https://hdl.handle.net/2445/192212 |
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Inglés |
| language_invalid_str_mv |
Inglés |
| dc.relation.none.fl_str_mv |
Reproducció del document publicat a: https://doi.org/10.3389/fpsyg.2022.813444 Frontiers in Psychology, 2022 https://doi.org/10.3389/fpsyg.2022.813444 |
| dc.rights.none.fl_str_mv |
cc-by (c) Redondo-Camós, María et al., 2022 https://creativecommons.org/licenses/by/4.0/ info:eu-repo/semantics/openAccess |
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cc-by (c) Redondo-Camós, María et al., 2022 https://creativecommons.org/licenses/by/4.0/ |
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openAccess |
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application/pdf |
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Frontiers Media |
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Frontiers Media |
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Articles publicats en revistes (Medicina) reponame:Dipòsit Digital de la UB instname:Universidad de Barcelona |
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Universidad de Barcelona |
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Dipòsit Digital de la UB |
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Dipòsit Digital de la UB |
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