Albocycline Is the Main Bioactive Antifungal Compound Produced by Streptomyces sp. OR6 against Verticillium dahliae

[EN] Verticillium wilt is a soil-borne fungal disease that affects olive trees (Olea europaea) and poses a serious threat to their cultivation. The causal agent of this disease is Verticillium dahliae, a pathogen that is difficult to control with conventional methods. Therefore, there is a need to e...

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Detalhes bibliográficos
Autores: Calvo Peña, Carla, Cobos Román, Rebeca, Sánchez López, José María, Ibáñez Sánchez, Ana María, Rubio Coque, Juan José
Tipo de documento: artigo
Estado:Versão publicada
Data de publicação:2023
País:España
Recursos:Universidad de León
Repositório:BULERIA. Repositorio Institucional de la Universidad de León
OAI Identifier:oai:buleria.unileon.es:10612/18012
Acesso em linha:https://www.mdpi.com/2223-7747/12/20/3612
https://hdl.handle.net/10612/18012
Access Level:Acceso aberto
Palavra-chave:Biotecnología
Verticillium dahliae
Verticillium wilt
Olive
Biocontrol
Antifungal
Albocycline
2415 Biología Molecular
2403 Bioquímica
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oai_identifier_str oai:buleria.unileon.es:10612/18012
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repository_id_str
spelling Albocycline Is the Main Bioactive Antifungal Compound Produced by Streptomyces sp. OR6 against Verticillium dahliaeCalvo Peña, CarlaCobos Román, RebecaSánchez López, José MaríaIbáñez Sánchez, Ana MaríaRubio Coque, Juan JoséBiotecnologíaVerticillium dahliaeVerticillium wiltOliveBiocontrolAntifungalAlbocycline2415 Biología Molecular2403 Bioquímica[EN] Verticillium wilt is a soil-borne fungal disease that affects olive trees (Olea europaea) and poses a serious threat to their cultivation. The causal agent of this disease is Verticillium dahliae, a pathogen that is difficult to control with conventional methods. Therefore, there is a need to explore alternative strategies for the management of Verticillium wilt. In this study, we aimed to isolate and characterize actinobacteria from the rhizosphere of olive trees that could act as potential biocontrol agents against V. dahliae. We selected a Streptomyces sp. OR6 strain based on its in vitro antifungal activity and its ability to suppress the pathogen growth in soil samples. We identified the main active compound produced by this strain as albocycline, a macrolide polyketide with known antibacterial properties and some antifungal activity. Albocycline was able to efficiently suppress the germination of conidiospores. To our knowledge, this is the first report of albocycline as an effective agent against V. dahliae. Our results suggest that Streptomyces sp. OR6, or other albocycline-producing strains, could be used as a promising tool for the biological control of Verticillium wilt.SIThis research was funded by Rio Lacarón S.L. (La Garrovilla, Badajoz, Spain). Carla Calvo-Peña (EDU/601/2020) was supported by a predoctoral contract from the Junta de Castilla y León and the European Social Fund. Ana Ibañez was supported by a “Margarita Salas” modality postdoctoral grant (Reference no.: UP2021-025) through the University of León awarded by the Spanish Ministry of Universities within the Recovery, Transformation and Resilience Plan (Modernization and digitalization of the Educational System), for which funding comes from the European Recovery Instrument European Union—NextGenerationEUMDPIMicrobiologiaFacultad de Ciencias Biologicas y Ambientales2023info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttps://www.mdpi.com/2223-7747/12/20/3612https://hdl.handle.net/10612/18012reponame:BULERIA. Repositorio Institucional de la Universidad de Leóninstname:Universidad de LeónIngléshttp://creativecommons.org/licenses/by-nc-nd/4.0/info:eu-repo/semantics/openAccessoai:buleria.unileon.es:10612/180122026-06-24T12:43:27Z
dc.title.none.fl_str_mv Albocycline Is the Main Bioactive Antifungal Compound Produced by Streptomyces sp. OR6 against Verticillium dahliae
title Albocycline Is the Main Bioactive Antifungal Compound Produced by Streptomyces sp. OR6 against Verticillium dahliae
spellingShingle Albocycline Is the Main Bioactive Antifungal Compound Produced by Streptomyces sp. OR6 against Verticillium dahliae
Calvo Peña, Carla
Biotecnología
Verticillium dahliae
Verticillium wilt
Olive
Biocontrol
Antifungal
Albocycline
2415 Biología Molecular
2403 Bioquímica
title_short Albocycline Is the Main Bioactive Antifungal Compound Produced by Streptomyces sp. OR6 against Verticillium dahliae
title_full Albocycline Is the Main Bioactive Antifungal Compound Produced by Streptomyces sp. OR6 against Verticillium dahliae
title_fullStr Albocycline Is the Main Bioactive Antifungal Compound Produced by Streptomyces sp. OR6 against Verticillium dahliae
title_full_unstemmed Albocycline Is the Main Bioactive Antifungal Compound Produced by Streptomyces sp. OR6 against Verticillium dahliae
title_sort Albocycline Is the Main Bioactive Antifungal Compound Produced by Streptomyces sp. OR6 against Verticillium dahliae
dc.creator.none.fl_str_mv Calvo Peña, Carla
Cobos Román, Rebeca
Sánchez López, José María
Ibáñez Sánchez, Ana María
Rubio Coque, Juan José
author Calvo Peña, Carla
author_facet Calvo Peña, Carla
Cobos Román, Rebeca
Sánchez López, José María
Ibáñez Sánchez, Ana María
Rubio Coque, Juan José
author_role author
author2 Cobos Román, Rebeca
Sánchez López, José María
Ibáñez Sánchez, Ana María
Rubio Coque, Juan José
author2_role author
author
author
author
dc.contributor.none.fl_str_mv Microbiologia
Facultad de Ciencias Biologicas y Ambientales
dc.subject.none.fl_str_mv Biotecnología
Verticillium dahliae
Verticillium wilt
Olive
Biocontrol
Antifungal
Albocycline
2415 Biología Molecular
2403 Bioquímica
topic Biotecnología
Verticillium dahliae
Verticillium wilt
Olive
Biocontrol
Antifungal
Albocycline
2415 Biología Molecular
2403 Bioquímica
description [EN] Verticillium wilt is a soil-borne fungal disease that affects olive trees (Olea europaea) and poses a serious threat to their cultivation. The causal agent of this disease is Verticillium dahliae, a pathogen that is difficult to control with conventional methods. Therefore, there is a need to explore alternative strategies for the management of Verticillium wilt. In this study, we aimed to isolate and characterize actinobacteria from the rhizosphere of olive trees that could act as potential biocontrol agents against V. dahliae. We selected a Streptomyces sp. OR6 strain based on its in vitro antifungal activity and its ability to suppress the pathogen growth in soil samples. We identified the main active compound produced by this strain as albocycline, a macrolide polyketide with known antibacterial properties and some antifungal activity. Albocycline was able to efficiently suppress the germination of conidiospores. To our knowledge, this is the first report of albocycline as an effective agent against V. dahliae. Our results suggest that Streptomyces sp. OR6, or other albocycline-producing strains, could be used as a promising tool for the biological control of Verticillium wilt.
publishDate 2023
dc.date.none.fl_str_mv 2023
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv https://www.mdpi.com/2223-7747/12/20/3612
https://hdl.handle.net/10612/18012
url https://www.mdpi.com/2223-7747/12/20/3612
https://hdl.handle.net/10612/18012
dc.language.none.fl_str_mv Inglés
language_invalid_str_mv Inglés
dc.rights.none.fl_str_mv http://creativecommons.org/licenses/by-nc-nd/4.0/
info:eu-repo/semantics/openAccess
rights_invalid_str_mv http://creativecommons.org/licenses/by-nc-nd/4.0/
eu_rights_str_mv openAccess
dc.publisher.none.fl_str_mv MDPI
publisher.none.fl_str_mv MDPI
dc.source.none.fl_str_mv reponame:BULERIA. Repositorio Institucional de la Universidad de León
instname:Universidad de León
instname_str Universidad de León
reponame_str BULERIA. Repositorio Institucional de la Universidad de León
collection BULERIA. Repositorio Institucional de la Universidad de León
repository.name.fl_str_mv
repository.mail.fl_str_mv
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