Oxytocin prevents the increase of cocaine-related responses produced by social defeat

The neuropeptide oxytocin (OXT) plays a critical role in the regulation of social and emotional behaviors. OXT plays a role in stress response and in drug reward, but to date no studies have evaluated its implication in the long-lasting increase of the motivational effects of cocaine induced by repe...

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Detalles Bibliográficos
Autores: Ferrer-Pérez, Carmen, Castro-Zavala, Adriana, Luján Pérez, Miguel Ángel, 1991-, Filarowska, Joanna, Ballestín, Raúl, Miñarro, José, Valverde Granados, Olga, Rodríguez-Arias, Marta
Tipo de recurso: artículo
Estado:Versión aceptada para publicación
Fecha de publicación:2019
País:España
Institución:Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)
Repositorio:Recercat. Dipósit de la Recerca de Catalunya
OAI Identifier:oai:recercat.cat:10230/41833
Acceso en línea:http://hdl.handle.net/10230/41833
http://dx.doi.org/10.1016/j.neuropharm.2018.11.011
Access Level:acceso abierto
Palabra clave:BDNF
Cocaine
Conditioned place preference
Oxytocin
Self-administration
Social defeat
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spelling Oxytocin prevents the increase of cocaine-related responses produced by social defeatFerrer-Pérez, CarmenCastro-Zavala, AdrianaLuján Pérez, Miguel Ángel, 1991-Filarowska, JoannaBallestín, RaúlMiñarro, JoséValverde Granados, OlgaRodríguez-Arias, MartaBDNFCocaineConditioned place preferenceOxytocinSelf-administrationSocial defeatThe neuropeptide oxytocin (OXT) plays a critical role in the regulation of social and emotional behaviors. OXT plays a role in stress response and in drug reward, but to date no studies have evaluated its implication in the long-lasting increase of the motivational effects of cocaine induced by repeated social defeat (RSD). During the social defeat procedure, 1 mg/kg of OXT was administered 30 min before each episode of RSD. Three weeks after the last defeat, the effects of cocaine on the conditioned place preference (CPP), locomotor sensitization and the self-administration (SA) paradigms were evaluated. The influence of OXT on the levels of BDNF in the prefrontal cortex (PFC), striatum and hippocampus was also measured. Our results confirm that raising the levels of OXT during social defeat stress can block the long-lasting effects of this type of stress. OXT counteracts the anxiety induced by social defeat and modifies BDNF levels in all the structures we have studied. Moreover, OXT prevents RSD-induced increases in the motivational effects of cocaine. Administration of OXT before each social defeat blocked the social defeat-induced increment in the conditioned rewarding effects of cocaine in the CPP, favored the extinction of cocaine-associated memories in both the CPP and SA, and decreased reinstatement of cocaine-seeking behavior in the SA. In conclusion, the long-lasting effects of RSD are counteracted by administering OXT prior to stress, and changes in BDNF expression may underlie these protective effects.This work was supported by the Ministerio de Economía y Competitividad, Dirección General de Investigación, [grant numbers PSI2014-51847-R and PSI 2017-83023-R]; Spanish Ministry of Economy, Innovation and Competiveness (SAF2016-75347-R). Instituto de Salud Carlos III, Red de Trastornos Adictivos (RTA) [grant numbers RETICS RD06/0001/1006; RD12/0028/0005; and RD/16/0017/0010] and Unión Europea, Fondos FEDER “A way to build Europe”. The Department of Experimental and Health Sciences (UPF) is an “Unidad de Excelencia María de Maeztu” funded by the MINECO (Ref. MDM2014-0370). A.C-Z received CONACYT grant from the Government of Mexico. M.A.L. and C.F.P received FPU grant from the Spanish Ministry of Economy, Innovation and Competiveness (15/02492 and 14/02279).Elsevier20192019info:eu-repo/semantics/articleinfo:eu-repo/semantics/acceptedVersionapplication/pdfapplication/pdfhttp://hdl.handle.net/10230/41833http://dx.doi.org/10.1016/j.neuropharm.2018.11.011reponame:Recercat. Dipósit de la Recerca de Catalunyainstname:Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)Inglésinfo:eu-repo/grantAgreement/ES/1PE/PSI2014-51847-Rinfo:eu-repo/grantAgreement/ES/2PE/PSI2017-83023-Rinfo:eu-repo/grantAgreement/ES/1PE/SAF2016-75347-R© Elsevier http://dx.doi.org/10.1016/j.neuropharm.2018.11.011info:eu-repo/semantics/openAccessoai:recercat.cat:10230/418332026-05-29T05:05:01Z
dc.title.none.fl_str_mv Oxytocin prevents the increase of cocaine-related responses produced by social defeat
title Oxytocin prevents the increase of cocaine-related responses produced by social defeat
spellingShingle Oxytocin prevents the increase of cocaine-related responses produced by social defeat
Ferrer-Pérez, Carmen
BDNF
Cocaine
Conditioned place preference
Oxytocin
Self-administration
Social defeat
title_short Oxytocin prevents the increase of cocaine-related responses produced by social defeat
title_full Oxytocin prevents the increase of cocaine-related responses produced by social defeat
title_fullStr Oxytocin prevents the increase of cocaine-related responses produced by social defeat
title_full_unstemmed Oxytocin prevents the increase of cocaine-related responses produced by social defeat
title_sort Oxytocin prevents the increase of cocaine-related responses produced by social defeat
dc.creator.none.fl_str_mv Ferrer-Pérez, Carmen
Castro-Zavala, Adriana
Luján Pérez, Miguel Ángel, 1991-
Filarowska, Joanna
Ballestín, Raúl
Miñarro, José
Valverde Granados, Olga
Rodríguez-Arias, Marta
author Ferrer-Pérez, Carmen
author_facet Ferrer-Pérez, Carmen
Castro-Zavala, Adriana
Luján Pérez, Miguel Ángel, 1991-
Filarowska, Joanna
Ballestín, Raúl
Miñarro, José
Valverde Granados, Olga
Rodríguez-Arias, Marta
author_role author
author2 Castro-Zavala, Adriana
Luján Pérez, Miguel Ángel, 1991-
Filarowska, Joanna
Ballestín, Raúl
Miñarro, José
Valverde Granados, Olga
Rodríguez-Arias, Marta
author2_role author
author
author
author
author
author
author
dc.subject.none.fl_str_mv BDNF
Cocaine
Conditioned place preference
Oxytocin
Self-administration
Social defeat
topic BDNF
Cocaine
Conditioned place preference
Oxytocin
Self-administration
Social defeat
description The neuropeptide oxytocin (OXT) plays a critical role in the regulation of social and emotional behaviors. OXT plays a role in stress response and in drug reward, but to date no studies have evaluated its implication in the long-lasting increase of the motivational effects of cocaine induced by repeated social defeat (RSD). During the social defeat procedure, 1 mg/kg of OXT was administered 30 min before each episode of RSD. Three weeks after the last defeat, the effects of cocaine on the conditioned place preference (CPP), locomotor sensitization and the self-administration (SA) paradigms were evaluated. The influence of OXT on the levels of BDNF in the prefrontal cortex (PFC), striatum and hippocampus was also measured. Our results confirm that raising the levels of OXT during social defeat stress can block the long-lasting effects of this type of stress. OXT counteracts the anxiety induced by social defeat and modifies BDNF levels in all the structures we have studied. Moreover, OXT prevents RSD-induced increases in the motivational effects of cocaine. Administration of OXT before each social defeat blocked the social defeat-induced increment in the conditioned rewarding effects of cocaine in the CPP, favored the extinction of cocaine-associated memories in both the CPP and SA, and decreased reinstatement of cocaine-seeking behavior in the SA. In conclusion, the long-lasting effects of RSD are counteracted by administering OXT prior to stress, and changes in BDNF expression may underlie these protective effects.
publishDate 2019
dc.date.none.fl_str_mv 2019
2019
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/acceptedVersion
format article
status_str acceptedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/10230/41833
http://dx.doi.org/10.1016/j.neuropharm.2018.11.011
url http://hdl.handle.net/10230/41833
http://dx.doi.org/10.1016/j.neuropharm.2018.11.011
dc.language.none.fl_str_mv Inglés
language_invalid_str_mv Inglés
dc.relation.none.fl_str_mv info:eu-repo/grantAgreement/ES/1PE/PSI2014-51847-R
info:eu-repo/grantAgreement/ES/2PE/PSI2017-83023-R
info:eu-repo/grantAgreement/ES/1PE/SAF2016-75347-R
dc.rights.none.fl_str_mv © Elsevier http://dx.doi.org/10.1016/j.neuropharm.2018.11.011
info:eu-repo/semantics/openAccess
rights_invalid_str_mv © Elsevier http://dx.doi.org/10.1016/j.neuropharm.2018.11.011
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
application/pdf
dc.publisher.none.fl_str_mv Elsevier
publisher.none.fl_str_mv Elsevier
dc.source.none.fl_str_mv reponame:Recercat. Dipósit de la Recerca de Catalunya
instname:Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)
instname_str Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)
reponame_str Recercat. Dipósit de la Recerca de Catalunya
collection Recercat. Dipósit de la Recerca de Catalunya
repository.name.fl_str_mv
repository.mail.fl_str_mv
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