Halide-Free Heterocyclic Divergence from Carbon Dioxide Enabled by a Binary Lewis Acid/Base CatalystClick to copy article link
A catalytic, halide-free process has been developed that builds on the use of a combination of a binary Al-based Lewis acid complex/base catalyst to access bicyclic, carbon dioxide-derived heterocycles in a selective and divergent approach. More specifically, strongly basic amines, such as DBU, faci...
| Autores: | , , , |
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| Tipo de recurso: | artículo |
| Fecha de publicación: | 2026 |
| País: | España |
| Institución: | Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya) |
| Repositorio: | Recercat. Dipósit de la Recerca de Catalunya |
| OAI Identifier: | oai:dnet:recercat____::beeadfe25213cf4cdbf0df3ba51ac620 |
| Acceso en línea: | https://hdl.handle.net/2072/489572 https://doi.org/10.1021/acscatal.6c02207 |
| Access Level: | acceso abierto |
| Palabra clave: | Química 54 |
| Sumario: | A catalytic, halide-free process has been developed that builds on the use of a combination of a binary Al-based Lewis acid complex/base catalyst to access bicyclic, carbon dioxide-derived heterocycles in a selective and divergent approach. More specifically, strongly basic amines, such as DBU, facilitate a sequence that features the initial formation of a bicyclic methylene-bridged seven-membered structure followed by a hemicarbonate-assisted rearrangement affording a thermodynamically more stable bicyclic, five-membered heterocyclic product. The presence of a less basic amine like DIPEA results in the predominant isolation of a relatively stable bicyclic, seven-membered cyclic carbonate. Our work shows the potential of dual Al/base catalytic activation of cyclic epoxy alcohols while exploring a larger chemical and structural space for CO2 conversion originating from a single precursor. |
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