Effects of Mindfulness and Exercise on Growth Factors, Inflammation, and Stress Markers in Chronic Stroke: The MindFit Project Randomized Clinical Trial
Atenció Plena; Exercici Físic; Ictus Crònic
| Autores: | , , , , , , , , , , , , |
|---|---|
| Tipo de recurso: | artículo |
| Estado: | Versión publicada |
| Fecha de publicación: | 2025 |
| País: | España |
| Institución: | Consejo Superior de Investigaciones Científicas (CSIC) |
| Repositorio: | Scientia. Dipòsit d'Informació Digital del Departament de Salut |
| OAI Identifier: | oai:scientiasalut.gencat.cat:11351/14156 |
| Acceso en línea: | http://hdl.handle.net/11351/14156 |
| Access Level: | acceso abierto |
| Palabra clave: | Atenció plena Exercici Isquèmia cerebral PSYCHIATRY AND PSYCHOLOGY::Psychological Phenomena::Mental Processes::Mindfulness PHENOMENA AND PROCESSES::Musculoskeletal and Neural Physiological Phenomena::Musculoskeletal Physiological Phenomena::Movement::Motor Activity::Exercise DISEASES::Nervous System Diseases::Central Nervous System Diseases::Brain Diseases::Cerebrovascular Disorders::Stroke PSIQUIATRÍA Y PSICOLOGÍA::fenómenos psicológicos::procesos mentales::atención plena FENÓMENOS Y PROCESOS::fenómenos fisiológicos nerviosos y musculoesqueléticos::fenómenos fisiológicos musculoesqueléticos::movimiento::actividad motora::ejercicio físico ENFERMEDADES::enfermedades del sistema nervioso::enfermedades del sistema nervioso central::enfermedades cerebrales::trastornos cerebrovasculares::accidente cerebrovascular |
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Effects of Mindfulness and Exercise on Growth Factors, Inflammation, and Stress Markers in Chronic Stroke: The MindFit Project Randomized Clinical Trial |
| title |
Effects of Mindfulness and Exercise on Growth Factors, Inflammation, and Stress Markers in Chronic Stroke: The MindFit Project Randomized Clinical Trial |
| spellingShingle |
Effects of Mindfulness and Exercise on Growth Factors, Inflammation, and Stress Markers in Chronic Stroke: The MindFit Project Randomized Clinical Trial Ariza, Mar Atenció plena Exercici Isquèmia cerebral PSYCHIATRY AND PSYCHOLOGY::Psychological Phenomena::Mental Processes::Mindfulness PHENOMENA AND PROCESSES::Musculoskeletal and Neural Physiological Phenomena::Musculoskeletal Physiological Phenomena::Movement::Motor Activity::Exercise DISEASES::Nervous System Diseases::Central Nervous System Diseases::Brain Diseases::Cerebrovascular Disorders::Stroke PSIQUIATRÍA Y PSICOLOGÍA::fenómenos psicológicos::procesos mentales::atención plena FENÓMENOS Y PROCESOS::fenómenos fisiológicos nerviosos y musculoesqueléticos::fenómenos fisiológicos musculoesqueléticos::movimiento::actividad motora::ejercicio físico ENFERMEDADES::enfermedades del sistema nervioso::enfermedades del sistema nervioso central::enfermedades cerebrales::trastornos cerebrovasculares::accidente cerebrovascular |
| title_short |
Effects of Mindfulness and Exercise on Growth Factors, Inflammation, and Stress Markers in Chronic Stroke: The MindFit Project Randomized Clinical Trial |
| title_full |
Effects of Mindfulness and Exercise on Growth Factors, Inflammation, and Stress Markers in Chronic Stroke: The MindFit Project Randomized Clinical Trial |
| title_fullStr |
Effects of Mindfulness and Exercise on Growth Factors, Inflammation, and Stress Markers in Chronic Stroke: The MindFit Project Randomized Clinical Trial |
| title_full_unstemmed |
Effects of Mindfulness and Exercise on Growth Factors, Inflammation, and Stress Markers in Chronic Stroke: The MindFit Project Randomized Clinical Trial |
| title_sort |
Effects of Mindfulness and Exercise on Growth Factors, Inflammation, and Stress Markers in Chronic Stroke: The MindFit Project Randomized Clinical Trial |
| dc.creator.none.fl_str_mv |
Ariza, Mar Agudelo Sánchez , Daniela Boldó, Maria Peters, Sarah Dacosta Aguayo, Rosalia Via, Marc Clemente, Imma Garcia-Molina, Alberto Dura Mata, Maria Jose Mataro, Maria Bermudo-Gallaguet, Adrià Camins-Vila, Neus Torán-Monserrat, Pere |
| author |
Ariza, Mar |
| author_facet |
Ariza, Mar Agudelo Sánchez , Daniela Boldó, Maria Peters, Sarah Dacosta Aguayo, Rosalia Via, Marc Clemente, Imma Garcia-Molina, Alberto Dura Mata, Maria Jose Mataro, Maria Bermudo-Gallaguet, Adrià Camins-Vila, Neus Torán-Monserrat, Pere |
| author_role |
author |
| author2 |
Agudelo Sánchez , Daniela Boldó, Maria Peters, Sarah Dacosta Aguayo, Rosalia Via, Marc Clemente, Imma Garcia-Molina, Alberto Dura Mata, Maria Jose Mataro, Maria Bermudo-Gallaguet, Adrià Camins-Vila, Neus Torán-Monserrat, Pere |
| author2_role |
author author author author author author author author author author author author |
| dc.contributor.none.fl_str_mv |
[Bermudo-Gallaguet A, Via M, Clemente IC, Mataró M] Departament de Psicologia Clínica i Psicobiologia, Facultat de psicologia, Universitat de Barcelona, Barcelona, Spain. Institut de Neurociències, Universitat de Barcelona, Barcelona, Spain. Institut de Recerca Sant Joan de Déu, Hospital Sant Joan de Déu, Esplugues de Llobregat, Spain. [Ariza M, Agudelo D, Peters S] Departament de Psicologia Clínica i Psicobiologia, Facultat de psicologia, Universitat de Barcelona, Barcelona, Spain. [Camins-Vila N] Institut Nacional d’Educació Física de Catalunya (INEFC), Universitat de Barcelona, Barcelona, Spain. [Boldó M, Durà Mata MJ] Servei de Rehabilitació, Hospital Universitari Germans Trias i Pujol, Campus Can Ruti, Badalona, Spain. Institut de Recerca Germans Trias i Pujol (IGTP), Campus Can Ruti, Badalona, Spain. [Dacosta-Aguayo R] Institut de Recerca Germans Trias i Pujol (IGTP), Campus Can Ruti, Badalona, Spain. Unitat de Suport a la Recerca Metropolitana Nord, Fundació Institut Universitari per a la Recerca a l’Atenció Primària de Salut Jordi Gol i Gurina, Mataró, Spain. [García-Molina A] Institut de Recerca Germans Trias i Pujol (IGTP), Campus Can Ruti, Badalona, Spain. Institut Guttmann, Universitat Autònoma de Barcelona, Bellaterra, Spain. [Torán-Montserrat P] Institut de Recerca Germans Trias i Pujol (IGTP), Campus Can Ruti, Badalona, Spain. Unitat de Suport a la Recerca Metropolitana Nord, Fundació Institut Universitari per a la Recerca a l’Atenció Primària de Salut Jordi Gol i Gurina, Mataró, Spain. Grup de recerca Multidisciplinar en Salut i Societat (GREMSAS),Mataró, Spain. Department of Medicine, Faculty of Medicine, Universitat de Girona, Girona, Spain Departament de Salut |
| dc.subject.none.fl_str_mv |
Atenció plena Exercici Isquèmia cerebral PSYCHIATRY AND PSYCHOLOGY::Psychological Phenomena::Mental Processes::Mindfulness PHENOMENA AND PROCESSES::Musculoskeletal and Neural Physiological Phenomena::Musculoskeletal Physiological Phenomena::Movement::Motor Activity::Exercise DISEASES::Nervous System Diseases::Central Nervous System Diseases::Brain Diseases::Cerebrovascular Disorders::Stroke PSIQUIATRÍA Y PSICOLOGÍA::fenómenos psicológicos::procesos mentales::atención plena FENÓMENOS Y PROCESOS::fenómenos fisiológicos nerviosos y musculoesqueléticos::fenómenos fisiológicos musculoesqueléticos::movimiento::actividad motora::ejercicio físico ENFERMEDADES::enfermedades del sistema nervioso::enfermedades del sistema nervioso central::enfermedades cerebrales::trastornos cerebrovasculares::accidente cerebrovascular |
| topic |
Atenció plena Exercici Isquèmia cerebral PSYCHIATRY AND PSYCHOLOGY::Psychological Phenomena::Mental Processes::Mindfulness PHENOMENA AND PROCESSES::Musculoskeletal and Neural Physiological Phenomena::Musculoskeletal Physiological Phenomena::Movement::Motor Activity::Exercise DISEASES::Nervous System Diseases::Central Nervous System Diseases::Brain Diseases::Cerebrovascular Disorders::Stroke PSIQUIATRÍA Y PSICOLOGÍA::fenómenos psicológicos::procesos mentales::atención plena FENÓMENOS Y PROCESOS::fenómenos fisiológicos nerviosos y musculoesqueléticos::fenómenos fisiológicos musculoesqueléticos::movimiento::actividad motora::ejercicio físico ENFERMEDADES::enfermedades del sistema nervioso::enfermedades del sistema nervioso central::enfermedades cerebrales::trastornos cerebrovasculares::accidente cerebrovascular |
| description |
Atenció Plena; Exercici Físic; Ictus Crònic |
| publishDate |
2025 |
| dc.date.none.fl_str_mv |
2025 2025 2025 |
| dc.type.none.fl_str_mv |
info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion |
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article |
| status_str |
publishedVersion |
| dc.identifier.none.fl_str_mv |
http://hdl.handle.net/11351/14156 |
| url |
http://hdl.handle.net/11351/14156 |
| dc.language.none.fl_str_mv |
Inglés |
| language_invalid_str_mv |
Inglés |
| dc.relation.none.fl_str_mv |
Journal of clinical medicine;14(8) https://www.doi.org/10.3390/jcm14082580 |
| dc.rights.none.fl_str_mv |
Attribution-NonCommercial 4.0 International Attribution-NonCommercial-NoDerivatives 4.0 International http://creativecommons.org/licenses/by-nc-nd/4.0/ info:eu-repo/semantics/openAccess |
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Attribution-NonCommercial 4.0 International Attribution-NonCommercial-NoDerivatives 4.0 International http://creativecommons.org/licenses/by-nc-nd/4.0/ |
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openAccess |
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application/pdf |
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J Clin Med |
| publisher.none.fl_str_mv |
J Clin Med |
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Scientia reponame:Scientia. Dipòsit d'Informació Digital del Departament de Salut instname:Consejo Superior de Investigaciones Científicas (CSIC) |
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Consejo Superior de Investigaciones Científicas (CSIC) |
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Scientia. Dipòsit d'Informació Digital del Departament de Salut |
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Scientia. Dipòsit d'Informació Digital del Departament de Salut |
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1869411040389758976 |
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Effects of Mindfulness and Exercise on Growth Factors, Inflammation, and Stress Markers in Chronic Stroke: The MindFit Project Randomized Clinical TrialAriza, MarAgudelo Sánchez , Daniela Boldó, MariaPeters, SarahDacosta Aguayo, RosaliaVia, MarcClemente, ImmaGarcia-Molina, AlbertoDura Mata, Maria JoseMataro, MariaBermudo-Gallaguet, AdriàCamins-Vila, NeusTorán-Monserrat, PereAtenció plenaExerciciIsquèmia cerebralPSYCHIATRY AND PSYCHOLOGY::Psychological Phenomena::Mental Processes::MindfulnessPHENOMENA AND PROCESSES::Musculoskeletal and Neural Physiological Phenomena::Musculoskeletal Physiological Phenomena::Movement::Motor Activity::ExerciseDISEASES::Nervous System Diseases::Central Nervous System Diseases::Brain Diseases::Cerebrovascular Disorders::StrokePSIQUIATRÍA Y PSICOLOGÍA::fenómenos psicológicos::procesos mentales::atención plenaFENÓMENOS Y PROCESOS::fenómenos fisiológicos nerviosos y musculoesqueléticos::fenómenos fisiológicos musculoesqueléticos::movimiento::actividad motora::ejercicio físicoENFERMEDADES::enfermedades del sistema nervioso::enfermedades del sistema nervioso central::enfermedades cerebrales::trastornos cerebrovasculares::accidente cerebrovascularAtenció Plena; Exercici Físic; Ictus CrònicMindfulness; Physical Exercise; Chronic StrokeAtención Plena; Ejercicio Físico; Ictus CrónicoStroke often leads to persistent cognitive and emotional impairments, which rehabilitation may mitigate. However, the biological mechanisms underlying such improvements remain unclear. This study investigated whether supplementing computerized cognitive training (CCT) with mindfulness-based stress reduction (MBSR) or physical exercise (PE) modulated biomarkers of neuroplasticity, inflammation, andstress in patients with chronic stroke compared to CCTalone. Wealsoexploredwhether biomarker changes mediated or correlated with behavioral improvements. Methods: In a three-arm, single-blind, randomized controlled trial (NCT04759950), 141 patients with chronic stroke were randomized (1:1:1) to MBSR+CCT, PE+CCT, or CCT-only for 12 weeks. Plasma levels of brain-derived neurotrophic factor (BDNF), insulin-like growth factor-1 (IGF-1), vascular endothelial growth factor (VEGF), C-reactive protein (CRP), interleukin-6 (IL-6), and cortisol were measured at baseline and post-intervention. Cognitive, mental health, mindfulness, and fitness outcomes were also assessed. Between- and within-group changes were analyzed using ANCOVA and paired t-tests. Per-protocol and complete-case analyses were conducted. Results: Among the 109 participants with ≥80% adherence, the only significant between-group difference was for VEGF: it remained stable in the MBSR+CCTgroupbut declined in PE+CCT and CCT-only. Within-group analyses showed significant decreases in cortisol in MBSR+CCT and PE+CCT, while IGF-1 levels declined across all groups. In contrast, BDNF, IL-6, and CRP did not show significant changes, and biomarker changes were not significantly associated with behavioral improvements. Complete-case analysis (n = 126) yielded similar findings. Conclusions: Our findings suggest that combining MBSR or PE with CCT may modulate certain biological processes relevant to stroke recovery. MBSR may help maintain VEGF levels, which could support vascular health, while MBSR and PE may contribute to lowering cortisol levels. However, since no clear association with behavioral improvements was found, further research is needed to determine the clinical relevance of these biomarker changes in stroke recovery.ThisresearchwasfundedbytheFundacióLaMaratódeTV3[grantnumber201717.30.31.32]. Additional support was provided to MM through the ICREA under the ICREA Academia program. AB-G received a pre-doctoral fellowship [grant number FPU18/04344].J Clin Med[Bermudo-Gallaguet A, Via M, Clemente IC, Mataró M] Departament de Psicologia Clínica i Psicobiologia, Facultat de psicologia, Universitat de Barcelona, Barcelona, Spain. Institut de Neurociències, Universitat de Barcelona, Barcelona, Spain. Institut de Recerca Sant Joan de Déu, Hospital Sant Joan de Déu, Esplugues de Llobregat, Spain. [Ariza M, Agudelo D, Peters S] Departament de Psicologia Clínica i Psicobiologia, Facultat de psicologia, Universitat de Barcelona, Barcelona, Spain. [Camins-Vila N] Institut Nacional d’Educació Física de Catalunya (INEFC), Universitat de Barcelona, Barcelona, Spain. [Boldó M, Durà Mata MJ] Servei de Rehabilitació, Hospital Universitari Germans Trias i Pujol, Campus Can Ruti, Badalona, Spain. Institut de Recerca Germans Trias i Pujol (IGTP), Campus Can Ruti, Badalona, Spain. [Dacosta-Aguayo R] Institut de Recerca Germans Trias i Pujol (IGTP), Campus Can Ruti, Badalona, Spain. Unitat de Suport a la Recerca Metropolitana Nord, Fundació Institut Universitari per a la Recerca a l’Atenció Primària de Salut Jordi Gol i Gurina, Mataró, Spain. [García-Molina A] Institut de Recerca Germans Trias i Pujol (IGTP), Campus Can Ruti, Badalona, Spain. Institut Guttmann, Universitat Autònoma de Barcelona, Bellaterra, Spain. [Torán-Montserrat P] Institut de Recerca Germans Trias i Pujol (IGTP), Campus Can Ruti, Badalona, Spain. Unitat de Suport a la Recerca Metropolitana Nord, Fundació Institut Universitari per a la Recerca a l’Atenció Primària de Salut Jordi Gol i Gurina, Mataró, Spain. Grup de recerca Multidisciplinar en Salut i Societat (GREMSAS),Mataró, Spain. Department of Medicine, Faculty of Medicine, Universitat de Girona, Girona, SpainDepartament de Salut202520252025info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionapplication/pdfhttp://hdl.handle.net/11351/14156Scientiareponame:Scientia. Dipòsit d'Informació Digital del Departament de Salutinstname:Consejo Superior de Investigaciones Científicas (CSIC)InglésJournal of clinical medicine;14(8)https://www.doi.org/10.3390/jcm14082580Attribution-NonCommercial 4.0 InternationalAttribution-NonCommercial-NoDerivatives 4.0 Internationalhttp://creativecommons.org/licenses/by-nc-nd/4.0/info:eu-repo/semantics/openAccessoai:scientiasalut.gencat.cat:11351/141562026-06-12T09:38:37Z |
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