Implications of Iron Deficiency in STEMI Patients and in a Murine Model of Myocardial Infarction

In patients with a first anterior ST-segment elevation myocardial infarction treated with primary percutaneous coronary intervention, iron deficiency (ID) was associated with larger infarcts, more extensive microvascular obstruction, and higher frequency of adverse left ventricular remodeling as ass...

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Detalles Bibliográficos
Autores: Inserte, Javier|||0000-0003-2283-3591, Barrabés, José A.|||0000-0001-7062-6277, Aluja, David|||0000-0002-0448-9419, Otaegui, Imanol|||0000-0001-6594-3139, Bañeras, Jordi|||0000-0002-7395-0862, Castellote, Laura, Sánchez, Ana, Rodríguez Palomares, José F.|||0000-0002-7229-9780, Pineda, Victor|||0000-0002-2227-0867, Miró-Casas, Elisabet|||0000-0002-2058-5961, Milà Pascual, Laia|||0009-0007-4932-657X, Lidón, Rosa María|||0000-0001-7008-2716, Sambola, Antonia, Valente, Filipa|||0000-0002-5569-3292, Rafecas, Agnès, Ruiz Meana, Marisol|||0000-0002-4067-4638, Rodríguez Sinovas, Antonio|||0000-0003-2930-8773, Benito Villabriga, Begoña|||0000-0002-8668-1251, Buera Surribas, Irene|||0000-0001-6110-2367, Delgado-Tomás, Sara, Beneitez Pastor, David|||0000-0002-6541-6600, Ferreira-Gonzalez, Ignacio|||0000-0002-1208-5561
Tipo de recurso: artículo
Fecha de publicación:2021
País:España
Institución:Universitat Autònoma de Barcelona
Repositorio:Dipòsit Digital de Documents de la UAB
Idioma:inglés
OAI Identifier:oai:ddd.uab.cat:248873
Acceso en línea:https://ddd.uab.cat/record/248873
https://dx.doi.org/urn:doi:10.1016/j.jacbts.2021.05.004
Access Level:acceso abierto
Palabra clave:Acute myocardial infarction
Endothelial nitric oxide synthase
Iron deficiency
Myocardial reperfusion
Soluble guanylate cyclase
CK-MB, creatine kinase-myocardial band
CMR, cardiac magnetic resonance
Enos, endothelial nitric oxide synthase
HSP90, heat-shock protein 90
ID, iron deficiency
Inos, inducible nitric oxide synthase
LV, left ventricular
MVO, microvascular obstruction
PKG, protein kinase G
Sgc, soluble guanylyl cyclase
STEMI, ST-segment elevation acute myocardial infarction
STIR, short tau inversion recovery
VASP, vasodilator-stimulated phosphoprotein
Descripción
Sumario:In patients with a first anterior ST-segment elevation myocardial infarction treated with primary percutaneous coronary intervention, iron deficiency (ID) was associated with larger infarcts, more extensive microvascular obstruction, and higher frequency of adverse left ventricular remodeling as assessed by cardiac magnetic resonance imaging. In mice, an ID diet reduced the activity of the endothelial nitric oxide synthase/soluble guanylate cyclase/protein kinase G pathway in association with oxidative/nitrosative stress and increased infarct size after transient coronary occlusion. Iron supplementation or administration of an sGC activator before ischemia prevented the effects of the ID diet in mice. Not only iron excess, but also ID, may have deleterious effects in the setting of ischemia and reperfusion.

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