Quality of life impact of hypoglossal nerve stimulation with inspire (R) device in patients with obstructive sleep apnea intolerant to continuous positive airway pressure therapy

Patients with obstructive sleep apnea (OSA) that do not tolerate/accept continuous positive airway pressure (CPAP) are candidates for surgical alternatives. Hypoglossal nerve stimulation (HNS) through the implantation of the Inspire (R) device constitutes a minimally invasive operative option. The m...

Descripción completa

Detalles Bibliográficos
Autores: Baptista-Jardin, P.M. (Peter Michael)|||/items/66ecbc41-d708-4b43-a527-b733813d5195, Di-Frisco-Ramírez, I.M. (Isberling Madeleine)|||/items/21c13471-dc26-4e42-b72a-fcd5dc8df298, Urrestarazu-Bolumburu, E. (Elena)|||/items/be7fd807-8726-4879-9e1e-3cf201af34f2, Alcalde, J. (Juan)|||/items/95d24e99-9ac3-41f7-9b55-4f6220bfbd23, Alegre-Esteban, M. (Manuel)|||/items/37771b48-4024-4472-9a17-cb6e2ac13579, Sánchez-Olivieri, I. (Isabel)|||/items/b78ccf63-c278-442f-b5cd-7997c26ed917, O’Connor-Reina, C. (Carlos)|||/items/5f02abf5-9355-4cf9-868a-f6eb1df7b4d7, Plaza, G. (Guillermo)|||/items/769de495-2430-40c5-b0c0-9739120b7868
Tipo de recurso: artículo
Fecha de publicación:2022
País:España
Institución:Universidad de Navarra
Repositorio:Dadun. Depósito Académico Digital de la Universidad de Navarra
Idioma:inglés
OAI Identifier:oai:dadun.unav.edu:10171/66026
Acceso en línea:https://hdl.handle.net/10171/66026
Access Level:acceso abierto
Palabra clave:Área de Medicina Clínica y Epidemiología
Quality of life
Obstructive sleep apnea
Hypoglossal nerve stimulation
Minimally invasive surgical technique
EuroQol-5D-5L
Descripción
Sumario:Patients with obstructive sleep apnea (OSA) that do not tolerate/accept continuous positive airway pressure (CPAP) are candidates for surgical alternatives. Hypoglossal nerve stimulation (HNS) through the implantation of the Inspire (R) device constitutes a minimally invasive operative option. The main objective of this study is to estimate, under real-world clinical practice conditions, the 3-month impact on the quality of life (IQoL) of the HNS in patients with moderate/severe OSA who do not tolerate or accept CPAP, compared to patients who did not receive HNS. As a baseline, the unadjusted EuroQol utility index was 0.764 (SD:0.190) in the intervention group (IGr) and 0.733 (SD:0.205) in the control group (CGr); three months later, the indexes were 0.935 (SD: 0.101) and 0.727 (SD:0.200), respectively. The positive impact on quality of life was estimated to be +0.177 (95% CI: 0.044-0.310; p = 0.010). All dimensions in the IGr improved compared to CGr, especially for usual activities (p < 0.001) and anxiety/depression (p > 0.001). At the end of the follow-up, there was no significant difference in the quality of life between the general Spanish population and the IGr (difference: 0.012; CI95%: -0.03 to -0.057; p = 0.0578) for the same age range; however, there was a difference concerning the CGr (difference: -0.196; CI95%: -0.257 to -0.135; p < 0.001). In conclusion, patients with moderate/severe OSA implanted with the Inspire (R) device showed a positive IQoL.

Similares en LA Referencia