Pro/anti-inflammatory disregulation in early psychosis: results from a longitudinal, case-control study

Background: Previous studies indicated a systemic deregulation of the pro-/antiinflammatory balance in subjects after 6 months of a first psychotic episode. This disruption was reexamined 12 months after diagnosis to identify potential risk/protective factors and associations with symptom severity....

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Autores: García Bueno, Borja, Bioque Alcázar, Miquel, MacDowell, Karina S., Santabárbara, Javier, Martínez Cengotitabengoa, Mónica, Moreno, Carmen (Moreno Koch), Saiz, Pilar A., Berrocoso, Esther, Gassó Astorga, Patricia, Barcones, M. Fe, González-Pinto, Ana, Parellada, Mara, Bobes García, Julio, Micó, Juan Antonio, Bernardo Arroyo, Miquel, Leza, Juan Carlos
Tipo de recurso: artículo
Estado:Versión publicada
Fecha de publicación:2015
País:España
Institución:Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)
Repositorio:Recercat. Dipósit de la Recerca de Catalunya
OAI Identifier:oai:recercat.cat:2445/112247
Acceso en línea:https://hdl.handle.net/2445/112247
Access Level:acceso abierto
Palabra clave:Psicosi
Inflamació
Antipsicòtics
Psychoses
Inflammation
Antipsychotic drugs
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spelling Pro/anti-inflammatory disregulation in early psychosis: results from a longitudinal, case-control studyGarcía Bueno, BorjaBioque Alcázar, MiquelMacDowell, Karina S.Santabárbara, JavierMartínez Cengotitabengoa, MónicaMoreno, Carmen (Moreno Koch)Saiz, Pilar A.Berrocoso, EstherGassó Astorga, PatriciaBarcones, M. FeGonzález-Pinto, AnaParellada, MaraBobes García, JulioMicó, Juan AntonioBernardo Arroyo, MiquelLeza, Juan CarlosPsicosiInflamacióAntipsicòticsPsychosesInflammationAntipsychotic drugsBackground: Previous studies indicated a systemic deregulation of the pro-/antiinflammatory balance in subjects after 6 months of a first psychotic episode. This disruption was reexamined 12 months after diagnosis to identify potential risk/protective factors and associations with symptom severity. Methods: Eighty-five subjects were followed during 12 months and the determination of the same pro-/antiinflammatory mediators was carried out in plasma and peripheral blood mononuclear cells. Multivariate logistic regression analyses were used to identify risk/protective factors. Multiple linear regression models were performed to detect the change of each biological marker during follow-up in relation to clinical characteristics and confounding factors. Results: This study suggests a more severe systemic pro-/antiinflammatory deregulation than in earlier pathological stages in first psychotic episode, because not only were intracellular components of the inflammatory response increased but also the majority of soluble elements. Nitrite plasma levels and cyclooxygenase-2 expression in peripheral blood mononuclear cells are reliable potential risk factors and 15d-prostaglandin-J2 plasma levels a protection biomarker. An interesting relationship exists between antipsychotic dose and the levels of prostaglandin-E2 (inverse) and 15d-prostaglandin-J2 (direct). An inverse relationship between the Global Assessment of Functioning scale and lipid peroxidation is also present. Conclusions: Summing up, pro-/antiinflammatory mediators can be used as risk/protection biomarkers. The inverse association between oxidative/nitrosative damage and the Global Assessment of Functioning scale, and the possibility that one of the targets of antipsychotics could be the restoration of the pro-/antiinflammatory balance support the use of antiinflammatory drugs as coadjuvant to antipsychotics.Oxford University Press2017201720152017info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersion10 p.application/pdfhttps://hdl.handle.net/2445/112247Articles publicats en revistes (Medicina)reponame:Recercat. Dipósit de la Recerca de Catalunyainstname:Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)InglésReproducció del document publicat a: https://doi.org/10.1093/ijnp/pyu037International Journal of Neuropsychopharmacology, 2015, vol. 18, num. 2, p. pyu037https://doi.org/10.1093/ijnp/pyu037cc-by-nc (c) García Bueno, Borja et al., 2015http://creativecommons.org/licenses/by-nc/3.0/esinfo:eu-repo/semantics/openAccessoai:recercat.cat:2445/1122472026-05-29T05:05:01Z
dc.title.none.fl_str_mv Pro/anti-inflammatory disregulation in early psychosis: results from a longitudinal, case-control study
title Pro/anti-inflammatory disregulation in early psychosis: results from a longitudinal, case-control study
spellingShingle Pro/anti-inflammatory disregulation in early psychosis: results from a longitudinal, case-control study
García Bueno, Borja
Psicosi
Inflamació
Antipsicòtics
Psychoses
Inflammation
Antipsychotic drugs
title_short Pro/anti-inflammatory disregulation in early psychosis: results from a longitudinal, case-control study
title_full Pro/anti-inflammatory disregulation in early psychosis: results from a longitudinal, case-control study
title_fullStr Pro/anti-inflammatory disregulation in early psychosis: results from a longitudinal, case-control study
title_full_unstemmed Pro/anti-inflammatory disregulation in early psychosis: results from a longitudinal, case-control study
title_sort Pro/anti-inflammatory disregulation in early psychosis: results from a longitudinal, case-control study
dc.creator.none.fl_str_mv García Bueno, Borja
Bioque Alcázar, Miquel
MacDowell, Karina S.
Santabárbara, Javier
Martínez Cengotitabengoa, Mónica
Moreno, Carmen (Moreno Koch)
Saiz, Pilar A.
Berrocoso, Esther
Gassó Astorga, Patricia
Barcones, M. Fe
González-Pinto, Ana
Parellada, Mara
Bobes García, Julio
Micó, Juan Antonio
Bernardo Arroyo, Miquel
Leza, Juan Carlos
author García Bueno, Borja
author_facet García Bueno, Borja
Bioque Alcázar, Miquel
MacDowell, Karina S.
Santabárbara, Javier
Martínez Cengotitabengoa, Mónica
Moreno, Carmen (Moreno Koch)
Saiz, Pilar A.
Berrocoso, Esther
Gassó Astorga, Patricia
Barcones, M. Fe
González-Pinto, Ana
Parellada, Mara
Bobes García, Julio
Micó, Juan Antonio
Bernardo Arroyo, Miquel
Leza, Juan Carlos
author_role author
author2 Bioque Alcázar, Miquel
MacDowell, Karina S.
Santabárbara, Javier
Martínez Cengotitabengoa, Mónica
Moreno, Carmen (Moreno Koch)
Saiz, Pilar A.
Berrocoso, Esther
Gassó Astorga, Patricia
Barcones, M. Fe
González-Pinto, Ana
Parellada, Mara
Bobes García, Julio
Micó, Juan Antonio
Bernardo Arroyo, Miquel
Leza, Juan Carlos
author2_role author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
dc.subject.none.fl_str_mv Psicosi
Inflamació
Antipsicòtics
Psychoses
Inflammation
Antipsychotic drugs
topic Psicosi
Inflamació
Antipsicòtics
Psychoses
Inflammation
Antipsychotic drugs
description Background: Previous studies indicated a systemic deregulation of the pro-/antiinflammatory balance in subjects after 6 months of a first psychotic episode. This disruption was reexamined 12 months after diagnosis to identify potential risk/protective factors and associations with symptom severity. Methods: Eighty-five subjects were followed during 12 months and the determination of the same pro-/antiinflammatory mediators was carried out in plasma and peripheral blood mononuclear cells. Multivariate logistic regression analyses were used to identify risk/protective factors. Multiple linear regression models were performed to detect the change of each biological marker during follow-up in relation to clinical characteristics and confounding factors. Results: This study suggests a more severe systemic pro-/antiinflammatory deregulation than in earlier pathological stages in first psychotic episode, because not only were intracellular components of the inflammatory response increased but also the majority of soluble elements. Nitrite plasma levels and cyclooxygenase-2 expression in peripheral blood mononuclear cells are reliable potential risk factors and 15d-prostaglandin-J2 plasma levels a protection biomarker. An interesting relationship exists between antipsychotic dose and the levels of prostaglandin-E2 (inverse) and 15d-prostaglandin-J2 (direct). An inverse relationship between the Global Assessment of Functioning scale and lipid peroxidation is also present. Conclusions: Summing up, pro-/antiinflammatory mediators can be used as risk/protection biomarkers. The inverse association between oxidative/nitrosative damage and the Global Assessment of Functioning scale, and the possibility that one of the targets of antipsychotics could be the restoration of the pro-/antiinflammatory balance support the use of antiinflammatory drugs as coadjuvant to antipsychotics.
publishDate 2015
dc.date.none.fl_str_mv 2015
2017
2017
2017
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv https://hdl.handle.net/2445/112247
url https://hdl.handle.net/2445/112247
dc.language.none.fl_str_mv Inglés
language_invalid_str_mv Inglés
dc.relation.none.fl_str_mv Reproducció del document publicat a: https://doi.org/10.1093/ijnp/pyu037
International Journal of Neuropsychopharmacology, 2015, vol. 18, num. 2, p. pyu037
https://doi.org/10.1093/ijnp/pyu037
dc.rights.none.fl_str_mv cc-by-nc (c) García Bueno, Borja et al., 2015
http://creativecommons.org/licenses/by-nc/3.0/es
info:eu-repo/semantics/openAccess
rights_invalid_str_mv cc-by-nc (c) García Bueno, Borja et al., 2015
http://creativecommons.org/licenses/by-nc/3.0/es
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv 10 p.
application/pdf
dc.publisher.none.fl_str_mv Oxford University Press
publisher.none.fl_str_mv Oxford University Press
dc.source.none.fl_str_mv Articles publicats en revistes (Medicina)
reponame:Recercat. Dipósit de la Recerca de Catalunya
instname:Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)
instname_str Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)
reponame_str Recercat. Dipósit de la Recerca de Catalunya
collection Recercat. Dipósit de la Recerca de Catalunya
repository.name.fl_str_mv
repository.mail.fl_str_mv
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score 15,811543

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